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Anxiolytic properties of Piper methysticum extract samples and fractions in the chick social-separation-stress procedure.
Phytother Res. 2003 Mar; 17(3):210-6.PR

Abstract

Piper methysticum extract (Kava kava) possesses anxiolytic properties. However, it is unknown whether these effects are best predicted by total kavalactone content or by one or more of its primary kavalactone constituents. Using the chick social separation-stress procedure as an anxiolytic bioassay, P. methysticum samples containing 12.8-100.0% total kavalactones (Exp. 1) and fractions containing 1-6 kavalactones of varying concentrations (0.1-67.5%; Exps. 2-3) were screened for activity and compared against a 5.0 mg/kg dose of chlordiazepoxide (CDP; Exp. 3). Eight-day-old chicks received IP injections of either vehicle or test compounds 30 min before being placed in the presence of two conspecifics or in isolation for a 3 min observation period. Dependent measures were ventral recumbency latency (sedation), distress vocalizations, and a measure of stress-induced analgesia (in Exps. 1 and 2 only). P. methysticum extract samples attenuated distress vocalizations in a concentration-dependent manner. The P. methysticum fraction that contained the highest concentration of dihydrokavain attenuated distress vocalizations in a manner equivalent to that of CDP. The extract samples and fractions that possessed anxiolytic properties did not possess the sedative properties found in CDP. Collectively, these findings suggest that dihydrokavain may be necessary and sufficient in mediating the anxiolytic properties of P. methysticum extract.

Authors+Show Affiliations

Department of Psychology, University of Mississippi, Oxford 38677, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

12672148

Citation

Feltenstein, Matt W., et al. "Anxiolytic Properties of Piper Methysticum Extract Samples and Fractions in the Chick Social-separation-stress Procedure." Phytotherapy Research : PTR, vol. 17, no. 3, 2003, pp. 210-6.
Feltenstein MW, Lambdin LC, Ganzera M, et al. Anxiolytic properties of Piper methysticum extract samples and fractions in the chick social-separation-stress procedure. Phytother Res. 2003;17(3):210-6.
Feltenstein, M. W., Lambdin, L. C., Ganzera, M., Ranjith, H., Dharmaratne, W., Nanayakkara, N. P., Khan, I. A., & Sufka, K. J. (2003). Anxiolytic properties of Piper methysticum extract samples and fractions in the chick social-separation-stress procedure. Phytotherapy Research : PTR, 17(3), 210-6.
Feltenstein MW, et al. Anxiolytic Properties of Piper Methysticum Extract Samples and Fractions in the Chick Social-separation-stress Procedure. Phytother Res. 2003;17(3):210-6. PubMed PMID: 12672148.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anxiolytic properties of Piper methysticum extract samples and fractions in the chick social-separation-stress procedure. AU - Feltenstein,Matt W, AU - Lambdin,L Corinne, AU - Ganzera,M, AU - Ranjith,H, AU - Dharmaratne,W, AU - Nanayakkara,N P Dhammika, AU - Khan,Ikhlas A, AU - Sufka,Kenneth J, PY - 2003/4/3/pubmed PY - 2003/5/28/medline PY - 2003/4/3/entrez SP - 210 EP - 6 JF - Phytotherapy research : PTR JO - Phytother Res VL - 17 IS - 3 N2 - Piper methysticum extract (Kava kava) possesses anxiolytic properties. However, it is unknown whether these effects are best predicted by total kavalactone content or by one or more of its primary kavalactone constituents. Using the chick social separation-stress procedure as an anxiolytic bioassay, P. methysticum samples containing 12.8-100.0% total kavalactones (Exp. 1) and fractions containing 1-6 kavalactones of varying concentrations (0.1-67.5%; Exps. 2-3) were screened for activity and compared against a 5.0 mg/kg dose of chlordiazepoxide (CDP; Exp. 3). Eight-day-old chicks received IP injections of either vehicle or test compounds 30 min before being placed in the presence of two conspecifics or in isolation for a 3 min observation period. Dependent measures were ventral recumbency latency (sedation), distress vocalizations, and a measure of stress-induced analgesia (in Exps. 1 and 2 only). P. methysticum extract samples attenuated distress vocalizations in a concentration-dependent manner. The P. methysticum fraction that contained the highest concentration of dihydrokavain attenuated distress vocalizations in a manner equivalent to that of CDP. The extract samples and fractions that possessed anxiolytic properties did not possess the sedative properties found in CDP. Collectively, these findings suggest that dihydrokavain may be necessary and sufficient in mediating the anxiolytic properties of P. methysticum extract. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/12672148/Anxiolytic_properties_of_Piper_methysticum_extract_samples_and_fractions_in_the_chick_social_separation_stress_procedure_ L2 - https://doi.org/10.1002/ptr.1107 DB - PRIME DP - Unbound Medicine ER -