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Antinociceptive and antipyretic activities of Pongamia pinnata leaves.
Phytother Res. 2003 Mar; 17(3):259-64.PR

Abstract

In the present study, the antinociceptive activity of a 70% ethanol extract of Pongamia pinnata leaves (PLE) was investigated in different models of pain in mice and rats. Further, PLE was also evaluated for its antipyretic activity in Brewer's yeast-induced pyrexia in rats. Per os (p.o.) administration of the PLE (100-1000 mg/kg) produced significant antinociceptive activity in the hotplate and tail flick (central) as well as in acetic acid writhing and Randall-Selitto (peripheral) nociceptive tests suggesting the involvement of both central and peripheral mechanisms in alleviating the pain response. In addition, PLE also exhibited a significant antipyretic response in Brewer's yeast-induced pyrexia in rats. These results demonstrated that PLE possesses marked antinociceptive as well as antipyretic activities and thus scientifically validated its use in the treatment of pain and pyretic disorders.

Authors+Show Affiliations

Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izat nagar (U. P.), 243 122, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12672157

Citation

Srinivasan, K, et al. "Antinociceptive and Antipyretic Activities of Pongamia Pinnata Leaves." Phytotherapy Research : PTR, vol. 17, no. 3, 2003, pp. 259-64.
Srinivasan K, Muruganandan S, Lal J, et al. Antinociceptive and antipyretic activities of Pongamia pinnata leaves. Phytother Res. 2003;17(3):259-64.
Srinivasan, K., Muruganandan, S., Lal, J., Chandra, S., Tandan, S. K., Raviprakash, V., & Kumar, D. (2003). Antinociceptive and antipyretic activities of Pongamia pinnata leaves. Phytotherapy Research : PTR, 17(3), 259-64.
Srinivasan K, et al. Antinociceptive and Antipyretic Activities of Pongamia Pinnata Leaves. Phytother Res. 2003;17(3):259-64. PubMed PMID: 12672157.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive and antipyretic activities of Pongamia pinnata leaves. AU - Srinivasan,K, AU - Muruganandan,S, AU - Lal,J, AU - Chandra,S, AU - Tandan,S K, AU - Raviprakash,V, AU - Kumar,D, PY - 2003/4/3/pubmed PY - 2003/5/28/medline PY - 2003/4/3/entrez SP - 259 EP - 64 JF - Phytotherapy research : PTR JO - Phytother Res VL - 17 IS - 3 N2 - In the present study, the antinociceptive activity of a 70% ethanol extract of Pongamia pinnata leaves (PLE) was investigated in different models of pain in mice and rats. Further, PLE was also evaluated for its antipyretic activity in Brewer's yeast-induced pyrexia in rats. Per os (p.o.) administration of the PLE (100-1000 mg/kg) produced significant antinociceptive activity in the hotplate and tail flick (central) as well as in acetic acid writhing and Randall-Selitto (peripheral) nociceptive tests suggesting the involvement of both central and peripheral mechanisms in alleviating the pain response. In addition, PLE also exhibited a significant antipyretic response in Brewer's yeast-induced pyrexia in rats. These results demonstrated that PLE possesses marked antinociceptive as well as antipyretic activities and thus scientifically validated its use in the treatment of pain and pyretic disorders. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/12672157/Antinociceptive_and_antipyretic_activities_of_Pongamia_pinnata_leaves_ L2 - https://doi.org/10.1002/ptr.1126 DB - PRIME DP - Unbound Medicine ER -