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Mutagenic and antimutagenic potential of the medicinal plants M. laevigata and C. xanthocarpa.
Phytother Res. 2003 Mar; 17(3):269-73.PR

Abstract

Aqueous extracts of medicinal plants (Mikania laevigata and Campomanesia xanthocarpa) were screened for the presence of mutagenic activity in the Salmonella/microsome assay. The extracts of Campomanesia xanthocarpa showed frameshift (TA97a strain) signs of mutagenic activity without exogenous metabolism (S9 fraction). The infusions of Mikania laevigata, negative for mutagenic activity, showed high percentages of inhibition of mutagenesis induced by mutagens 2AF (2-amino fluorene), in the presence of exogenous metabolism (S9 fraction), for frameshift (TA98) and base pair substitution (TA100) lesions. In addition, these inhibitions were observed against mutagen SAZ (sodium azide) in assays with the TA100 strain, without exogenous metabolism (S9 fraction). A synergistic effect was also observed in frameshift mutagenic events, with direct action in the presence of 4NQO (4-oxide-1-nitroquinoline) and a tendency to a low percentage of action enhancement, in the presence of the 2AF mutagen. The variable responses observed in the extract assays show the potentials for interaction of the different active principles in genetic material.

Authors+Show Affiliations

Fernandes JB
Fundação Estadual de Proteção Ambiental Henrique Luis Roessler-FEPAM, Programa de Pesquisas, Ambientais, Av. Salvador França, 1707, 90690-000, Porto Alegre, RS, Brazil.
Vargas VM
No affiliation info available

MeSH

Antimutagenic AgentsDose-Response Relationship, DrugFluorenesHumansMikaniaMutagenicity TestsMutagensMyrtaceaePhytotherapyPlant ExtractsSalmonella typhimurium

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12672159

Citation

Fernandes, J B F., and V M F. Vargas. "Mutagenic and Antimutagenic Potential of the Medicinal Plants M. Laevigata and C. Xanthocarpa." Phytotherapy Research : PTR, vol. 17, no. 3, 2003, pp. 269-73.
Fernandes JB, Vargas VM. Mutagenic and antimutagenic potential of the medicinal plants M. laevigata and C. xanthocarpa. Phytother Res. 2003;17(3):269-73.
Fernandes, J. B., & Vargas, V. M. (2003). Mutagenic and antimutagenic potential of the medicinal plants M. laevigata and C. xanthocarpa. Phytotherapy Research : PTR, 17(3), 269-73.
Fernandes JB, Vargas VM. Mutagenic and Antimutagenic Potential of the Medicinal Plants M. Laevigata and C. Xanthocarpa. Phytother Res. 2003;17(3):269-73. PubMed PMID: 12672159.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mutagenic and antimutagenic potential of the medicinal plants M. laevigata and C. xanthocarpa. AU - Fernandes,J B F, AU - Vargas,V M F, PY - 2003/4/3/pubmed PY - 2003/5/28/medline PY - 2003/4/3/entrez SP - 269 EP - 73 JF - Phytotherapy research : PTR JO - Phytother Res VL - 17 IS - 3 N2 - Aqueous extracts of medicinal plants (Mikania laevigata and Campomanesia xanthocarpa) were screened for the presence of mutagenic activity in the Salmonella/microsome assay. The extracts of Campomanesia xanthocarpa showed frameshift (TA97a strain) signs of mutagenic activity without exogenous metabolism (S9 fraction). The infusions of Mikania laevigata, negative for mutagenic activity, showed high percentages of inhibition of mutagenesis induced by mutagens 2AF (2-amino fluorene), in the presence of exogenous metabolism (S9 fraction), for frameshift (TA98) and base pair substitution (TA100) lesions. In addition, these inhibitions were observed against mutagen SAZ (sodium azide) in assays with the TA100 strain, without exogenous metabolism (S9 fraction). A synergistic effect was also observed in frameshift mutagenic events, with direct action in the presence of 4NQO (4-oxide-1-nitroquinoline) and a tendency to a low percentage of action enhancement, in the presence of the 2AF mutagen. The variable responses observed in the extract assays show the potentials for interaction of the different active principles in genetic material. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/12672159/Mutagenic_and_antimutagenic_potential_of_the_medicinal_plants_M__laevigata_and_C__xanthocarpa_ DB - PRIME DP - Unbound Medicine ER -