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Differences in the behavioral and psychological symptoms between Alzheimer's disease and vascular dementia: are the different pharmacologic treatment strategies justifiable?
Hum Psychopharmacol. 2003 Apr; 18(3):215-20.HP

Abstract

BACKGROUND

This study aimed (1) to compare the behavioral and psychological symptoms of dementia (BPSD) between patients with Alzheimer's disease (AD) and vascular dementia (VaD); (2) to investigate the differences in the correlates of BPSD between them; and (3) to suggest potential different pharmacological strategies in treating BPSD of either etiology.

METHODS

In a study group of 135 patients with dementia (99 AD, 36 VaD), information on age, gender, education, age at onset and duration of dementia was collected. The severity of dementia was measured by the following assessment scales: Korean version of Mini-Mental State Examination (MMSE-K) for cognitive function; Blessed Dementia Scale (BDS) for functional activities of daily living (ADL); Barthel Index (BI) for physical ADL; and Brief Psychiatric Rating Scale (BPRS), Hamilton Depression Scale (HAM-D) and Hamilton Anxiety Scale (HAM-A) for BPSD. The independent variables between the patients with AD and VaD were compared, and then the correlations of BPSD with other variables were estimated.

RESULTS

HAM-D and HAM-A scores were higher in patients with VaD than in those with AD, while other variables demonstrated no statistical differences. BPRS score correlated with scores on MMSE-K, BDS and BI in AD, but only with BDS in VaD. The HAM-D score correlated with scores on BDS and BI in AD, but only with BDS in VaD. The HAM-A score was correlated with score on BDS in AD not in VaD.

CONCLUSIONS

BPSD were more severe in the patients with VaD. However, BPSD correlated more prominently with cognitive or ADL impairments in patients with AD. Different treatment approaches to BPSD may be required according to the clinical differentiation of dementia type.

Authors+Show Affiliations

Department of Psychiatry, College of Medicine, Chosun University, Kwangju, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12672174

Citation

Kim, Jae-Min, et al. "Differences in the Behavioral and Psychological Symptoms Between Alzheimer's Disease and Vascular Dementia: Are the Different Pharmacologic Treatment Strategies Justifiable?" Human Psychopharmacology, vol. 18, no. 3, 2003, pp. 215-20.
Kim JM, Lyons D, Shin IS, et al. Differences in the behavioral and psychological symptoms between Alzheimer's disease and vascular dementia: are the different pharmacologic treatment strategies justifiable? Hum Psychopharmacol. 2003;18(3):215-20.
Kim, J. M., Lyons, D., Shin, I. S., & Yoon, J. S. (2003). Differences in the behavioral and psychological symptoms between Alzheimer's disease and vascular dementia: are the different pharmacologic treatment strategies justifiable? Human Psychopharmacology, 18(3), 215-20.
Kim JM, et al. Differences in the Behavioral and Psychological Symptoms Between Alzheimer's Disease and Vascular Dementia: Are the Different Pharmacologic Treatment Strategies Justifiable. Hum Psychopharmacol. 2003;18(3):215-20. PubMed PMID: 12672174.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differences in the behavioral and psychological symptoms between Alzheimer's disease and vascular dementia: are the different pharmacologic treatment strategies justifiable? AU - Kim,Jae-Min, AU - Lyons,Declan, AU - Shin,Il-Seon, AU - Yoon,Jin-Sang, PY - 2003/4/3/pubmed PY - 2003/8/23/medline PY - 2003/4/3/entrez SP - 215 EP - 20 JF - Human psychopharmacology JO - Hum Psychopharmacol VL - 18 IS - 3 N2 - BACKGROUND: This study aimed (1) to compare the behavioral and psychological symptoms of dementia (BPSD) between patients with Alzheimer's disease (AD) and vascular dementia (VaD); (2) to investigate the differences in the correlates of BPSD between them; and (3) to suggest potential different pharmacological strategies in treating BPSD of either etiology. METHODS: In a study group of 135 patients with dementia (99 AD, 36 VaD), information on age, gender, education, age at onset and duration of dementia was collected. The severity of dementia was measured by the following assessment scales: Korean version of Mini-Mental State Examination (MMSE-K) for cognitive function; Blessed Dementia Scale (BDS) for functional activities of daily living (ADL); Barthel Index (BI) for physical ADL; and Brief Psychiatric Rating Scale (BPRS), Hamilton Depression Scale (HAM-D) and Hamilton Anxiety Scale (HAM-A) for BPSD. The independent variables between the patients with AD and VaD were compared, and then the correlations of BPSD with other variables were estimated. RESULTS: HAM-D and HAM-A scores were higher in patients with VaD than in those with AD, while other variables demonstrated no statistical differences. BPRS score correlated with scores on MMSE-K, BDS and BI in AD, but only with BDS in VaD. The HAM-D score correlated with scores on BDS and BI in AD, but only with BDS in VaD. The HAM-A score was correlated with score on BDS in AD not in VaD. CONCLUSIONS: BPSD were more severe in the patients with VaD. However, BPSD correlated more prominently with cognitive or ADL impairments in patients with AD. Different treatment approaches to BPSD may be required according to the clinical differentiation of dementia type. SN - 0885-6222 UR - https://www.unboundmedicine.com/medline/citation/12672174/Differences_in_the_behavioral_and_psychological_symptoms_between_Alzheimer's_disease_and_vascular_dementia:_are_the_different_pharmacologic_treatment_strategies_justifiable L2 - https://doi.org/10.1002/hup.466 DB - PRIME DP - Unbound Medicine ER -