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Outcome of positive antinuclear antibodies in individuals without connective tissue disease.
J Rheumatol. 2003 Apr; 30(4):736-9.JR

Abstract

OBJECTIVE

To determine if individuals with high titer antinuclear antibodies (ANA) but without clinical evidence of connective tissue disease (CTD) subsequently develop CTD or experience a change in ANA positivity.

METHODS

We included patients from an initial study database as well as those reviewed in an outpatient rheumatology clinic at the University of Alberta Hospital over the past 8 years. A telephone survey targeting signs and symptoms of CTD was conducted. Serum samples from consenting patients were then assayed for ANA, antibodies to extractable nuclear antigens (ENA), and anti-dsDNA by the Rheumatic Disease Unit at the University of Alberta Hospital.

RESULTS

Sixty-two patients completed the telephone survey and 53 completed both the telephone survey and repeat serological blood investigations. Mean length of followup was 5.4 years, with an age range from 19 to 87 years. Forty-eight of 53 patients (91%) remained ANA positive on repeat testing, and 5 patients were also ENA positive. Three patients had been diagnosed with CTD since the previous study. The most common clinical features on telephone survey included joint pain (34 patients) followed by Raynaud's phenomenon (11 patients).

CONCLUSION

Patients tended to remain ANA positive on repeat testing. Three out of 53 patients had developed CTD, reflecting the more sensitive but less specific nature of ANA testing. Another common condition associated with ANA positivity was hypothyroidism. Continued longterm followup with larger cohorts is needed.

Authors+Show Affiliations

Division of Rheumatology, University of Alberta, Edmonton, Alberta, Canada.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12672192

Citation

Myckatyn, Stephanie O., and Anthony S. Russell. "Outcome of Positive Antinuclear Antibodies in Individuals Without Connective Tissue Disease." The Journal of Rheumatology, vol. 30, no. 4, 2003, pp. 736-9.
Myckatyn SO, Russell AS. Outcome of positive antinuclear antibodies in individuals without connective tissue disease. J Rheumatol. 2003;30(4):736-9.
Myckatyn, S. O., & Russell, A. S. (2003). Outcome of positive antinuclear antibodies in individuals without connective tissue disease. The Journal of Rheumatology, 30(4), 736-9.
Myckatyn SO, Russell AS. Outcome of Positive Antinuclear Antibodies in Individuals Without Connective Tissue Disease. J Rheumatol. 2003;30(4):736-9. PubMed PMID: 12672192.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Outcome of positive antinuclear antibodies in individuals without connective tissue disease. AU - Myckatyn,Stephanie O, AU - Russell,Anthony S, PY - 2003/4/3/pubmed PY - 2003/7/19/medline PY - 2003/4/3/entrez SP - 736 EP - 9 JF - The Journal of rheumatology JO - J. Rheumatol. VL - 30 IS - 4 N2 - OBJECTIVE: To determine if individuals with high titer antinuclear antibodies (ANA) but without clinical evidence of connective tissue disease (CTD) subsequently develop CTD or experience a change in ANA positivity. METHODS: We included patients from an initial study database as well as those reviewed in an outpatient rheumatology clinic at the University of Alberta Hospital over the past 8 years. A telephone survey targeting signs and symptoms of CTD was conducted. Serum samples from consenting patients were then assayed for ANA, antibodies to extractable nuclear antigens (ENA), and anti-dsDNA by the Rheumatic Disease Unit at the University of Alberta Hospital. RESULTS: Sixty-two patients completed the telephone survey and 53 completed both the telephone survey and repeat serological blood investigations. Mean length of followup was 5.4 years, with an age range from 19 to 87 years. Forty-eight of 53 patients (91%) remained ANA positive on repeat testing, and 5 patients were also ENA positive. Three patients had been diagnosed with CTD since the previous study. The most common clinical features on telephone survey included joint pain (34 patients) followed by Raynaud's phenomenon (11 patients). CONCLUSION: Patients tended to remain ANA positive on repeat testing. Three out of 53 patients had developed CTD, reflecting the more sensitive but less specific nature of ANA testing. Another common condition associated with ANA positivity was hypothyroidism. Continued longterm followup with larger cohorts is needed. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/12672192/Outcome_of_positive_antinuclear_antibodies_in_individuals_without_connective_tissue_disease_ L2 - http://www.jrheum.org/cgi/pmidlookup?view=long&pmid=12672192 DB - PRIME DP - Unbound Medicine ER -