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Structural differences between the alkali-extracted water-soluble cell wall polysaccharides from mycelial and yeast phases of the pathogenic dimorphic fungus Paracoccidioides brasiliensis.
Glycobiology. 2003 Nov; 13(11):743-7.G

Abstract

Paracoccidioides brasiliensis is a pathogenic dimorphic fungus causing paracoccidioidomycosis, the most widespread systemic mycosis in Latin America. We have studied the structure of the alkali-extracted water-soluble cell wall polysaccharides (F1SS) from both mycelial and yeast phases of this fungus by using chemical analysis and NMR spectroscopic techniques. The F1SS polysaccharide from the mycelial phase consists of a trisaccharidic repeating unit of -->6)-[alpha-Galf -(1-->6)-alpha-Manp-(1-->2)]-alpha-Manp-(1-->. The F1SS polysaccharide of the yeast phase maintains 10% of the structure of the mycelium phase, but the main structure contain a disaccharide repeating unit of -->6)-[-alpha-Manp-(1-->2)]-alpha-Manp-(1-->, alternating with a trisaccharide repeating block of -->6)-[beta-Galf -(1-->6)-alpha-Manp-(1-->2)]-alpha-Manp-(1-->.

Authors+Show Affiliations

Ahrazem O
Centro de Investigaciones Biológicas, CSIC, Velázquez 144, 28006-Madrid, Spain.
Prieto A
No affiliation info available
San-Blas G
No affiliation info available
Leal JA
No affiliation info available
Jiménez-Barbero J
No affiliation info available
Bernabé M
No affiliation info available

MeSH

Carbohydrate ConformationCell WallMagnetic Resonance SpectroscopyMyceliumParacoccidioidesPolysaccharidesYeasts

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12672703

Citation

Ahrazem, Oussama, et al. "Structural Differences Between the Alkali-extracted Water-soluble Cell Wall Polysaccharides From Mycelial and Yeast Phases of the Pathogenic Dimorphic Fungus Paracoccidioides Brasiliensis." Glycobiology, vol. 13, no. 11, 2003, pp. 743-7.
Ahrazem O, Prieto A, San-Blas G, et al. Structural differences between the alkali-extracted water-soluble cell wall polysaccharides from mycelial and yeast phases of the pathogenic dimorphic fungus Paracoccidioides brasiliensis. Glycobiology. 2003;13(11):743-7.
Ahrazem, O., Prieto, A., San-Blas, G., Leal, J. A., Jiménez-Barbero, J., & Bernabé, M. (2003). Structural differences between the alkali-extracted water-soluble cell wall polysaccharides from mycelial and yeast phases of the pathogenic dimorphic fungus Paracoccidioides brasiliensis. Glycobiology, 13(11), 743-7.
Ahrazem O, et al. Structural Differences Between the Alkali-extracted Water-soluble Cell Wall Polysaccharides From Mycelial and Yeast Phases of the Pathogenic Dimorphic Fungus Paracoccidioides Brasiliensis. Glycobiology. 2003;13(11):743-7. PubMed PMID: 12672703.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Structural differences between the alkali-extracted water-soluble cell wall polysaccharides from mycelial and yeast phases of the pathogenic dimorphic fungus Paracoccidioides brasiliensis. AU - Ahrazem,Oussama, AU - Prieto,Alicia, AU - San-Blas,Gioconda, AU - Leal,Juan Antonio, AU - Jiménez-Barbero,Jesus, AU - Bernabé,Manuel, Y1 - 2003/04/02/ PY - 2003/4/4/pubmed PY - 2004/8/18/medline PY - 2003/4/4/entrez SP - 743 EP - 7 JF - Glycobiology JO - Glycobiology VL - 13 IS - 11 N2 - Paracoccidioides brasiliensis is a pathogenic dimorphic fungus causing paracoccidioidomycosis, the most widespread systemic mycosis in Latin America. We have studied the structure of the alkali-extracted water-soluble cell wall polysaccharides (F1SS) from both mycelial and yeast phases of this fungus by using chemical analysis and NMR spectroscopic techniques. The F1SS polysaccharide from the mycelial phase consists of a trisaccharidic repeating unit of -->6)-[alpha-Galf -(1-->6)-alpha-Manp-(1-->2)]-alpha-Manp-(1-->. The F1SS polysaccharide of the yeast phase maintains 10% of the structure of the mycelium phase, but the main structure contain a disaccharide repeating unit of -->6)-[-alpha-Manp-(1-->2)]-alpha-Manp-(1-->, alternating with a trisaccharide repeating block of -->6)-[beta-Galf -(1-->6)-alpha-Manp-(1-->2)]-alpha-Manp-(1-->. SN - 0959-6658 UR - https://www.unboundmedicine.com/medline/citation/12672703/Structural_differences_between_the_alkali_extracted_water_soluble_cell_wall_polysaccharides_from_mycelial_and_yeast_phases_of_the_pathogenic_dimorphic_fungus_Paracoccidioides_brasiliensis_ DB - PRIME DP - Unbound Medicine ER -