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Effects of hormone replacement therapy on mammographic findings.
Arch Gynecol Obstet. 2003 Apr; 268(1):5-8.AG

Abstract

To evaluate the effects of different hormone replacement therapy (HRT) protocols on mammographic findings. One-hundred-eighty-two women in menopause were recruited for this prospective study. Breast examination was performed and four basal mammograms were obtained in all cases. Eighty of the cases received HRT by estrogen only; 40 used combined pills of estrogen plus progestagen sequentially; 44 used combined pills of estrogen plus progestagen continuously; 18 used tibolone. Breast examination and mammography were repeated after 11.6+/-2.1 months of HRT. Mammographic parenchymal density was found to be increased in all cases (17.6%). This finding was most prominent in the continuous combined estrogen plus progestagen group (25%) and the lowest in the tibolone group (5.5%). The use of estradiol resulted in more increased density than conjugated estrogen. The increase in the mammographic density is related directly with breast tenderness. Hormone replacement therapy is not contraindicated in the cases of breast disease without atypia. The increase in mammographic density was found to be higher in obese women.

Authors+Show Affiliations

Zeynep Kamil Women and Children's Education and Research Hospital, Istanbul, Turkey.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12673467

Citation

Bülbül, Nur Hilal, et al. "Effects of Hormone Replacement Therapy On Mammographic Findings." Archives of Gynecology and Obstetrics, vol. 268, no. 1, 2003, pp. 5-8.
Bülbül NH, Ozden S, Dayicioglu V. Effects of hormone replacement therapy on mammographic findings. Arch Gynecol Obstet. 2003;268(1):5-8.
Bülbül, N. H., Ozden, S., & Dayicioglu, V. (2003). Effects of hormone replacement therapy on mammographic findings. Archives of Gynecology and Obstetrics, 268(1), 5-8.
Bülbül NH, Ozden S, Dayicioglu V. Effects of Hormone Replacement Therapy On Mammographic Findings. Arch Gynecol Obstet. 2003;268(1):5-8. PubMed PMID: 12673467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of hormone replacement therapy on mammographic findings. AU - Bülbül,Nur Hilal, AU - Ozden,Selcuk, AU - Dayicioglu,Vedat, Y1 - 2002/06/06/ PY - 2001/10/26/received PY - 2001/12/31/accepted PY - 2003/4/4/pubmed PY - 2003/10/1/medline PY - 2003/4/4/entrez SP - 5 EP - 8 JF - Archives of gynecology and obstetrics JO - Arch. Gynecol. Obstet. VL - 268 IS - 1 N2 - To evaluate the effects of different hormone replacement therapy (HRT) protocols on mammographic findings. One-hundred-eighty-two women in menopause were recruited for this prospective study. Breast examination was performed and four basal mammograms were obtained in all cases. Eighty of the cases received HRT by estrogen only; 40 used combined pills of estrogen plus progestagen sequentially; 44 used combined pills of estrogen plus progestagen continuously; 18 used tibolone. Breast examination and mammography were repeated after 11.6+/-2.1 months of HRT. Mammographic parenchymal density was found to be increased in all cases (17.6%). This finding was most prominent in the continuous combined estrogen plus progestagen group (25%) and the lowest in the tibolone group (5.5%). The use of estradiol resulted in more increased density than conjugated estrogen. The increase in the mammographic density is related directly with breast tenderness. Hormone replacement therapy is not contraindicated in the cases of breast disease without atypia. The increase in mammographic density was found to be higher in obese women. SN - 0932-0067 UR - https://www.unboundmedicine.com/medline/citation/12673467/Effects_of_hormone_replacement_therapy_on_mammographic_findings_ L2 - https://dx.doi.org/10.1007/s00404-002-0306-7 DB - PRIME DP - Unbound Medicine ER -