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Empiric risk of prostate carcinoma for relatives of patients with prostate carcinoma: a meta-analysis.
Cancer 2003; 97(8):1894-903C

Abstract

BACKGROUND

Although narrative reviews have concluded that there is strong support for familial clustering of prostate carcinoma, the association has never systematically been quantified in reviews. The purpose of this meta-analysis was to summarize and quantify the recurrence risk ratio with emphasis on the degree of relation, the specific relationship of the family member, the number of affected family members, and the age at diagnosis.

METHODS

Publications were identified through computerized database searches for epidemiologic studies published up to December 2002. In addition, references cited in original and review papers were examined. Three blinded reviewers extracted both qualitative and quantitative information from each paper. Using random effects meta-regression analyses, the authors calculated summary recurrence risk ratios (S(lambda)). The reviewers also evaluated changes in S(lambda) according to differences in study methodology.

RESULTS

Thirty-three epidemiologic studies were included in the current review. S(lambda) was 2.53 (95% confidence interval, 2.24-2.85) for first-degree family members. S(lambda) appeared to be greater for men with an affected brother than for men with an affected father. S(lambda) for men who had second-degree relatives with prostate carcinoma was only slightly elevated. The nature of the familial clustering is such that S(lambda) increases with decreasing age of the patient and family members, with increasing genetic relatedness of the affected relative, and with increasing number of individuals affected within a family.

CONCLUSIONS

The studies that were reviewed consistently demonstrate that family history is a significant risk factor for development of prostate carcinoma.

Authors+Show Affiliations

Department of Epidemiology, Maastricht University, Maastricht, The Netherlands. mpa.zeegers@epid.unimaas.nlNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Meta-Analysis
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12673715

Citation

Zeegers, Maurice P A., et al. "Empiric Risk of Prostate Carcinoma for Relatives of Patients With Prostate Carcinoma: a Meta-analysis." Cancer, vol. 97, no. 8, 2003, pp. 1894-903.
Zeegers MP, Jellema A, Ostrer H. Empiric risk of prostate carcinoma for relatives of patients with prostate carcinoma: a meta-analysis. Cancer. 2003;97(8):1894-903.
Zeegers, M. P., Jellema, A., & Ostrer, H. (2003). Empiric risk of prostate carcinoma for relatives of patients with prostate carcinoma: a meta-analysis. Cancer, 97(8), pp. 1894-903.
Zeegers MP, Jellema A, Ostrer H. Empiric Risk of Prostate Carcinoma for Relatives of Patients With Prostate Carcinoma: a Meta-analysis. Cancer. 2003 Apr 15;97(8):1894-903. PubMed PMID: 12673715.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Empiric risk of prostate carcinoma for relatives of patients with prostate carcinoma: a meta-analysis. AU - Zeegers,Maurice P A, AU - Jellema,Annemarie, AU - Ostrer,Harry, PY - 2003/4/4/pubmed PY - 2003/5/8/medline PY - 2003/4/4/entrez SP - 1894 EP - 903 JF - Cancer JO - Cancer VL - 97 IS - 8 N2 - BACKGROUND: Although narrative reviews have concluded that there is strong support for familial clustering of prostate carcinoma, the association has never systematically been quantified in reviews. The purpose of this meta-analysis was to summarize and quantify the recurrence risk ratio with emphasis on the degree of relation, the specific relationship of the family member, the number of affected family members, and the age at diagnosis. METHODS: Publications were identified through computerized database searches for epidemiologic studies published up to December 2002. In addition, references cited in original and review papers were examined. Three blinded reviewers extracted both qualitative and quantitative information from each paper. Using random effects meta-regression analyses, the authors calculated summary recurrence risk ratios (S(lambda)). The reviewers also evaluated changes in S(lambda) according to differences in study methodology. RESULTS: Thirty-three epidemiologic studies were included in the current review. S(lambda) was 2.53 (95% confidence interval, 2.24-2.85) for first-degree family members. S(lambda) appeared to be greater for men with an affected brother than for men with an affected father. S(lambda) for men who had second-degree relatives with prostate carcinoma was only slightly elevated. The nature of the familial clustering is such that S(lambda) increases with decreasing age of the patient and family members, with increasing genetic relatedness of the affected relative, and with increasing number of individuals affected within a family. CONCLUSIONS: The studies that were reviewed consistently demonstrate that family history is a significant risk factor for development of prostate carcinoma. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/12673715/Empiric_risk_of_prostate_carcinoma_for_relatives_of_patients_with_prostate_carcinoma:_a_meta_analysis_ L2 - https://doi.org/10.1002/cncr.11262 DB - PRIME DP - Unbound Medicine ER -