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Thrombin signaling in the brain: the role of protease-activated receptors.
Biol Chem. 2003 Feb; 384(2):193-202.BC

Abstract

Signaling by the protease thrombin has started to be appreciated in cell biology, especially since the gene for protease-activated receptor-1 (PAR-1) has been cloned. Apart from the central role of thrombin in blood coagulation and wound healing, thrombin also regulates cellular functions in a large variety of cells through PAR-1, PAR-3 and PAR-4. Receptors are activated by a proteolytic cleavage mechanism via G protein-coupled signaling pathways. Accumulating evidence shows that thrombin changes the morphology of neurons and astrocytes, induces glial cell proliferation, and even exerts, depending on the concentration applied, either cytoprotective or cytotoxic effects on neural cells. These effects may be mediated, through either distinct or overlapping signal transduction cascades, by activation of PARs. This review focuses on the underlying signaling events initiated by thrombin in neuronal and glial cells, to summarize our understanding of the intracellular signaling machinery linking thrombin receptors to their potential physiological and pathological functions in the CNS.

Authors+Show Affiliations

Institut für Neurobiochemie, Medizinische Fakultät der Otto-von-Guericke-Universität Magdeburg, Leipziger Strasse 44, D-39120 Magdeburg, Germany.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

12675511

Citation

Wang, Hong, and Georg Reiser. "Thrombin Signaling in the Brain: the Role of Protease-activated Receptors." Biological Chemistry, vol. 384, no. 2, 2003, pp. 193-202.
Wang H, Reiser G. Thrombin signaling in the brain: the role of protease-activated receptors. Biol Chem. 2003;384(2):193-202.
Wang, H., & Reiser, G. (2003). Thrombin signaling in the brain: the role of protease-activated receptors. Biological Chemistry, 384(2), 193-202.
Wang H, Reiser G. Thrombin Signaling in the Brain: the Role of Protease-activated Receptors. Biol Chem. 2003;384(2):193-202. PubMed PMID: 12675511.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thrombin signaling in the brain: the role of protease-activated receptors. AU - Wang,Hong, AU - Reiser,Georg, PY - 2003/4/5/pubmed PY - 2003/10/17/medline PY - 2003/4/5/entrez SP - 193 EP - 202 JF - Biological chemistry JO - Biol Chem VL - 384 IS - 2 N2 - Signaling by the protease thrombin has started to be appreciated in cell biology, especially since the gene for protease-activated receptor-1 (PAR-1) has been cloned. Apart from the central role of thrombin in blood coagulation and wound healing, thrombin also regulates cellular functions in a large variety of cells through PAR-1, PAR-3 and PAR-4. Receptors are activated by a proteolytic cleavage mechanism via G protein-coupled signaling pathways. Accumulating evidence shows that thrombin changes the morphology of neurons and astrocytes, induces glial cell proliferation, and even exerts, depending on the concentration applied, either cytoprotective or cytotoxic effects on neural cells. These effects may be mediated, through either distinct or overlapping signal transduction cascades, by activation of PARs. This review focuses on the underlying signaling events initiated by thrombin in neuronal and glial cells, to summarize our understanding of the intracellular signaling machinery linking thrombin receptors to their potential physiological and pathological functions in the CNS. SN - 1431-6730 UR - https://www.unboundmedicine.com/medline/citation/12675511/Thrombin_signaling_in_the_brain:_the_role_of_protease_activated_receptors_ L2 - https://www.degruyter.com/doi/10.1515/BC.2003.021 DB - PRIME DP - Unbound Medicine ER -