Tags

Type your tag names separated by a space and hit enter

The influence of dietary intake on the insulin-like growth factor (IGF) system across three ethnic groups: a population-based study.

Abstract

OBJECTIVE

The insulin-like growth factor (IGF) system has been implicated in the aetiopathogenesis of cancer, cardiovascular disease and diabetes. Since dietary factors and ethnicity are considered contributory to the development of these diseases, we examined the IGF system in relation to nutritional intake by ethnic group.

DESIGN, SUBJECTS AND SETTING

Dietary intake in 257 subjects of White European, African-Caribbean and Pakistani ethnic origin living in Manchester, UK was assessed using ethnic-group-specific food-frequency questionnaires to assess habitual nutrient intake over the previous 12 months. Fasting IGF-I, IGF-II and IGF-binding protein-1 (IGFBP-1) concentrations were determined and their relationship to specific dietary constituents was analysed.

RESULTS

Analysis by quintiles of nutrient intake showed a significant increase in circulating IGF-I concentration with increasing dietary fat intake (F for trend=3.9, ), saturated fat intake and for protein intake There was also a significant increase in IGF-II by quintiles of dietary protein intake There was a trend for increasing IGF-I with increasing energy intake. The relationships between circulating concentration of IGFBP-1, an acute regulator of IGF action, and fat/protein intake were opposite to those for IGF-I and IGF-II. Multiple linear regression modelling showed that people of Pakistani origin and older subjects had lower levels of IGF-I (Pakistani origin vs. others, ) (age, for both). There was an independent inverse relationship between IGF-I and dietary carbohydrate intake

CONCLUSIONS

This study provides evidence for a dietary contribution to regulation of the IGF system, although the effects of ethnicity on circulating IGF levels remain dominant. We propose that the IGF system's influences on cancer risk in specific ethnic groups are potentially modifiable by dietary intervention.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Diabetes, University of Manchester, Salford Royal Hospitals University Trust, Hope Hospital, Stott Lane, Greater Manchester M6 8HD. aheald@fs1.ho.man.ac.uk

    , , , ,

    Source

    Public health nutrition 6:2 2003 Apr pg 175-80

    MeSH

    Adult
    Africa
    Age Factors
    Aged
    Cardiovascular Diseases
    Caribbean Region
    Diet
    Dietary Fats
    Dietary Proteins
    England
    Ethnic Groups
    Europe
    Female
    Humans
    Insulin-Like Growth Factor Binding Protein 1
    Insulin-Like Growth Factor I
    Insulin-Like Growth Factor II
    Male
    Middle Aged
    Neoplasms
    Pakistan
    Regression Analysis
    Somatomedins
    Surveys and Questionnaires

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    12675960

    Citation

    Heald, A H., et al. "The Influence of Dietary Intake On the Insulin-like Growth Factor (IGF) System Across Three Ethnic Groups: a Population-based Study." Public Health Nutrition, vol. 6, no. 2, 2003, pp. 175-80.
    Heald AH, Cade JE, Cruickshank JK, et al. The influence of dietary intake on the insulin-like growth factor (IGF) system across three ethnic groups: a population-based study. Public Health Nutr. 2003;6(2):175-80.
    Heald, A. H., Cade, J. E., Cruickshank, J. K., Anderson, S., White, A., & Gibson, J. M. (2003). The influence of dietary intake on the insulin-like growth factor (IGF) system across three ethnic groups: a population-based study. Public Health Nutrition, 6(2), pp. 175-80.
    Heald AH, et al. The Influence of Dietary Intake On the Insulin-like Growth Factor (IGF) System Across Three Ethnic Groups: a Population-based Study. Public Health Nutr. 2003;6(2):175-80. PubMed PMID: 12675960.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The influence of dietary intake on the insulin-like growth factor (IGF) system across three ethnic groups: a population-based study. AU - Heald,A H, AU - Cade,J E, AU - Cruickshank,J K, AU - Anderson,S, AU - White,A, AU - Gibson,J M, PY - 2003/4/5/pubmed PY - 2003/10/31/medline PY - 2003/4/5/entrez SP - 175 EP - 80 JF - Public health nutrition JO - Public Health Nutr VL - 6 IS - 2 N2 - OBJECTIVE: The insulin-like growth factor (IGF) system has been implicated in the aetiopathogenesis of cancer, cardiovascular disease and diabetes. Since dietary factors and ethnicity are considered contributory to the development of these diseases, we examined the IGF system in relation to nutritional intake by ethnic group. DESIGN, SUBJECTS AND SETTING: Dietary intake in 257 subjects of White European, African-Caribbean and Pakistani ethnic origin living in Manchester, UK was assessed using ethnic-group-specific food-frequency questionnaires to assess habitual nutrient intake over the previous 12 months. Fasting IGF-I, IGF-II and IGF-binding protein-1 (IGFBP-1) concentrations were determined and their relationship to specific dietary constituents was analysed. RESULTS: Analysis by quintiles of nutrient intake showed a significant increase in circulating IGF-I concentration with increasing dietary fat intake (F for trend=3.9, ), saturated fat intake and for protein intake There was also a significant increase in IGF-II by quintiles of dietary protein intake There was a trend for increasing IGF-I with increasing energy intake. The relationships between circulating concentration of IGFBP-1, an acute regulator of IGF action, and fat/protein intake were opposite to those for IGF-I and IGF-II. Multiple linear regression modelling showed that people of Pakistani origin and older subjects had lower levels of IGF-I (Pakistani origin vs. others, ) (age, for both). There was an independent inverse relationship between IGF-I and dietary carbohydrate intake CONCLUSIONS: This study provides evidence for a dietary contribution to regulation of the IGF system, although the effects of ethnicity on circulating IGF levels remain dominant. We propose that the IGF system's influences on cancer risk in specific ethnic groups are potentially modifiable by dietary intervention. SN - 1368-9800 UR - https://www.unboundmedicine.com/medline/citation/12675960/full_citation L2 - https://www.cambridge.org/core/product/identifier/S1368980003000235/type/journal_article DB - PRIME DP - Unbound Medicine ER -