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The influence of dietary intake on the insulin-like growth factor (IGF) system across three ethnic groups: a population-based study.
Public Health Nutr 2003; 6(2):175-80PH

Abstract

OBJECTIVE

The insulin-like growth factor (IGF) system has been implicated in the aetiopathogenesis of cancer, cardiovascular disease and diabetes. Since dietary factors and ethnicity are considered contributory to the development of these diseases, we examined the IGF system in relation to nutritional intake by ethnic group.

DESIGN, SUBJECTS AND SETTING

Dietary intake in 257 subjects of White European, African-Caribbean and Pakistani ethnic origin living in Manchester, UK was assessed using ethnic-group-specific food-frequency questionnaires to assess habitual nutrient intake over the previous 12 months. Fasting IGF-I, IGF-II and IGF-binding protein-1 (IGFBP-1) concentrations were determined and their relationship to specific dietary constituents was analysed.

RESULTS

Analysis by quintiles of nutrient intake showed a significant increase in circulating IGF-I concentration with increasing dietary fat intake (F for trend=3.9,), saturated fat intake and for protein intake There was also a significant increase in IGF-II by quintiles of dietary protein intake There was a trend for increasing IGF-I with increasing energy intake. The relationships between circulating concentration of IGFBP-1, an acute regulator of IGF action, and fat/protein intake were opposite to those for IGF-I and IGF-II. Multiple linear regression modelling showed that people of Pakistani origin and older subjects had lower levels of IGF-I (Pakistani origin vs. others,) (age, for both). There was an independent inverse relationship between IGF-I and dietary carbohydrate intake

CONCLUSIONS

This study provides evidence for a dietary contribution to regulation of the IGF system, although the effects of ethnicity on circulating IGF levels remain dominant. We propose that the IGF system's influences on cancer risk in specific ethnic groups are potentially modifiable by dietary intervention.

Authors+Show Affiliations

Department of Diabetes, University of Manchester, Salford Royal Hospitals University Trust, Hope Hospital, Stott Lane, Greater Manchester M6 8HD. aheald@fs1.ho.man.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12675960

Citation

Heald, A H., et al. "The Influence of Dietary Intake On the Insulin-like Growth Factor (IGF) System Across Three Ethnic Groups: a Population-based Study." Public Health Nutrition, vol. 6, no. 2, 2003, pp. 175-80.
Heald AH, Cade JE, Cruickshank JK, et al. The influence of dietary intake on the insulin-like growth factor (IGF) system across three ethnic groups: a population-based study. Public Health Nutr. 2003;6(2):175-80.
Heald, A. H., Cade, J. E., Cruickshank, J. K., Anderson, S., White, A., & Gibson, J. M. (2003). The influence of dietary intake on the insulin-like growth factor (IGF) system across three ethnic groups: a population-based study. Public Health Nutrition, 6(2), pp. 175-80.
Heald AH, et al. The Influence of Dietary Intake On the Insulin-like Growth Factor (IGF) System Across Three Ethnic Groups: a Population-based Study. Public Health Nutr. 2003;6(2):175-80. PubMed PMID: 12675960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of dietary intake on the insulin-like growth factor (IGF) system across three ethnic groups: a population-based study. AU - Heald,A H, AU - Cade,J E, AU - Cruickshank,J K, AU - Anderson,S, AU - White,A, AU - Gibson,J M, PY - 2003/4/5/pubmed PY - 2003/10/31/medline PY - 2003/4/5/entrez SP - 175 EP - 80 JF - Public health nutrition JO - Public Health Nutr VL - 6 IS - 2 N2 - OBJECTIVE: The insulin-like growth factor (IGF) system has been implicated in the aetiopathogenesis of cancer, cardiovascular disease and diabetes. Since dietary factors and ethnicity are considered contributory to the development of these diseases, we examined the IGF system in relation to nutritional intake by ethnic group. DESIGN, SUBJECTS AND SETTING: Dietary intake in 257 subjects of White European, African-Caribbean and Pakistani ethnic origin living in Manchester, UK was assessed using ethnic-group-specific food-frequency questionnaires to assess habitual nutrient intake over the previous 12 months. Fasting IGF-I, IGF-II and IGF-binding protein-1 (IGFBP-1) concentrations were determined and their relationship to specific dietary constituents was analysed. RESULTS: Analysis by quintiles of nutrient intake showed a significant increase in circulating IGF-I concentration with increasing dietary fat intake (F for trend=3.9,), saturated fat intake and for protein intake There was also a significant increase in IGF-II by quintiles of dietary protein intake There was a trend for increasing IGF-I with increasing energy intake. The relationships between circulating concentration of IGFBP-1, an acute regulator of IGF action, and fat/protein intake were opposite to those for IGF-I and IGF-II. Multiple linear regression modelling showed that people of Pakistani origin and older subjects had lower levels of IGF-I (Pakistani origin vs. others,) (age, for both). There was an independent inverse relationship between IGF-I and dietary carbohydrate intake CONCLUSIONS: This study provides evidence for a dietary contribution to regulation of the IGF system, although the effects of ethnicity on circulating IGF levels remain dominant. We propose that the IGF system's influences on cancer risk in specific ethnic groups are potentially modifiable by dietary intervention. SN - 1368-9800 UR - https://www.unboundmedicine.com/medline/citation/12675960/full_citation L2 - https://www.cambridge.org/core/product/identifier/S1368980003000235/type/journal_article DB - PRIME DP - Unbound Medicine ER -