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[Fluctuations and dyskinesias as early L-dopa-induced motor complications in severe Parkinsonian's patients].
Neurologia. 2003 Apr; 18(3):162-5.N

Abstract

Daily fluctuations of motor performance and dyskinesias in patients with Parkinson's disease (PD) treated with levodopa represent a difficult challenge to our understanding. We report 10 patients diagnosed of severe PD (Hoehn and Yahr: III-IV/V) treated with levodopa (range of dose: 750-900 mg/day) in single drug therapy since their diagnosis (mean time of levodopatherapy: 4.8 2.4 months, range: 3-6 months). All patients developed motor complications within weeks to months after initiating L-dopatherapy. Two patients received an intravenous apomorphine infusion (mean dose: 8.5 mg/day) during a mean time of 7.5 hours, but motor complications persisted during the infusion in spite of continuous dopaminergic stimulus. The degree of nigrostriatal damage (disease severity) seems to be a very important risk factor for the development of treatment-related motor complications.

Authors+Show Affiliations

Vaamonde J
Servicio de Neurología, Complejo Hospitalario de Ciudad Real, Spain. jvaamonde@hnsa.insalud.es
Ibáñez R
No affiliation info available
Gudín M
No affiliation info available
Hernández A
No affiliation info available

MeSH

AgedAntiparkinson AgentsApomorphineDopamine AgonistsDyskinesia, Drug-InducedFemaleHumansLevodopaMaleMiddle AgedParkinson DiseaseRisk Factors

Pub Type(s)

English Abstract
Journal Article

Language

spa

PubMed ID

12677484

Citation

Vaamonde, J, et al. "[Fluctuations and Dyskinesias as Early L-dopa-induced Motor Complications in Severe Parkinsonian's Patients]." Neurologia (Barcelona, Spain), vol. 18, no. 3, 2003, pp. 162-5.
Vaamonde J, Ibáñez R, Gudín M, et al. [Fluctuations and dyskinesias as early L-dopa-induced motor complications in severe Parkinsonian's patients]. Neurologia. 2003;18(3):162-5.
Vaamonde, J., Ibáñez, R., Gudín, M., & Hernández, A. (2003). [Fluctuations and dyskinesias as early L-dopa-induced motor complications in severe Parkinsonian's patients]. Neurologia (Barcelona, Spain), 18(3), 162-5.
Vaamonde J, et al. [Fluctuations and Dyskinesias as Early L-dopa-induced Motor Complications in Severe Parkinsonian's Patients]. Neurologia. 2003;18(3):162-5. PubMed PMID: 12677484.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Fluctuations and dyskinesias as early L-dopa-induced motor complications in severe Parkinsonian's patients]. AU - Vaamonde,J, AU - Ibáñez,R, AU - Gudín,M, AU - Hernández,A, PY - 2003/4/5/pubmed PY - 2003/9/26/medline PY - 2003/4/5/entrez SP - 162 EP - 5 JF - Neurologia (Barcelona, Spain) JO - Neurologia VL - 18 IS - 3 N2 - Daily fluctuations of motor performance and dyskinesias in patients with Parkinson's disease (PD) treated with levodopa represent a difficult challenge to our understanding. We report 10 patients diagnosed of severe PD (Hoehn and Yahr: III-IV/V) treated with levodopa (range of dose: 750-900 mg/day) in single drug therapy since their diagnosis (mean time of levodopatherapy: 4.8 2.4 months, range: 3-6 months). All patients developed motor complications within weeks to months after initiating L-dopatherapy. Two patients received an intravenous apomorphine infusion (mean dose: 8.5 mg/day) during a mean time of 7.5 hours, but motor complications persisted during the infusion in spite of continuous dopaminergic stimulus. The degree of nigrostriatal damage (disease severity) seems to be a very important risk factor for the development of treatment-related motor complications. SN - 0213-4853 UR - https://www.unboundmedicine.com/medline/citation/12677484/[Fluctuations_and_dyskinesias_as_early_L_dopa_induced_motor_complications_in_severe_Parkinsonian's_patients]_ DB - PRIME DP - Unbound Medicine ER -