Tags

Type your tag names separated by a space and hit enter

Gastrointestinal manifestations of cow's milk protein allergy during the first year of life.
J Med Assoc Thai 2003; 86(2):116-23JM

Abstract

BACKGROUND

Cow's milk protein sensitive enteropathy (CMPSE) is a common condition in the first year of life. Clinically CMPSE usually presents with symptoms like vomiting, chronic diarrhea, mucous bloody diarrhea and hematemesis. More unusual symptoms associated with CMPSE are infantile colic, gastroesophageal reflux and chronic constipation. The objective of this study was to assess the gastrointestinal manifestations and allergic march in CMPSE patients.

METHOD

The authors reviewed the records of 10 CMPSE patients observed by the Gastrointestinal Unit at King Chulalongkorn Memorial Hospital from 1997-2001 including patient characteristics, laboratory investigations, endoscopy and follow-up outcome.

RESULTS

Of 10 CMPSE patients, the median age of CMPSE onset was 3.5 months. The gastrointestinal manifestations were hematemesis (n = 6), mucous bloody diarrhea (n = 3) and chronic watery diarrhea (n = 2). Exclusively breast-fed infants seemed to have more delayed onset of symptoms than those who were not. Anemia (n = 3), high serum IgE (n = 4) and positive skin prick test for cow's milk (n = 5) were found. Neither peripheral eosinophilia nor hypoalbuminemia was found. Endoscopy revealed acute and chronic gastritis. Treatment was successful by changing to soy or extensive hydrolysate formula with mean duration of cow's milk intolerance of 24 months. In 2-year follow-up, three of ten patients who had high serum IgE level developed allergic rhinitis and eczema.

CONCLUSION

CMPSE can be manifested in various symptoms. Exclusive breast feeding for more than 4 months can postpone the onset of CMPSE. Serum IgE or specific IgE level to cow's milk protein may identify the atopic career of CMPSE individuals.

Authors+Show Affiliations

Gastroenterology Division, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12678148

Citation

Yimyaem, Phisek, et al. "Gastrointestinal Manifestations of Cow's Milk Protein Allergy During the First Year of Life." Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, vol. 86, no. 2, 2003, pp. 116-23.
Yimyaem P, Chongsrisawat V, Vivatvakin B, et al. Gastrointestinal manifestations of cow's milk protein allergy during the first year of life. J Med Assoc Thai. 2003;86(2):116-23.
Yimyaem, P., Chongsrisawat, V., Vivatvakin, B., & Wisedopas, N. (2003). Gastrointestinal manifestations of cow's milk protein allergy during the first year of life. Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, 86(2), pp. 116-23.
Yimyaem P, et al. Gastrointestinal Manifestations of Cow's Milk Protein Allergy During the First Year of Life. J Med Assoc Thai. 2003;86(2):116-23. PubMed PMID: 12678148.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastrointestinal manifestations of cow's milk protein allergy during the first year of life. AU - Yimyaem,Phisek, AU - Chongsrisawat,Voranush, AU - Vivatvakin,Boosba, AU - Wisedopas,Naruemon, PY - 2003/4/8/pubmed PY - 2003/4/26/medline PY - 2003/4/8/entrez SP - 116 EP - 23 JF - Journal of the Medical Association of Thailand = Chotmaihet thangphaet JO - J Med Assoc Thai VL - 86 IS - 2 N2 - BACKGROUND: Cow's milk protein sensitive enteropathy (CMPSE) is a common condition in the first year of life. Clinically CMPSE usually presents with symptoms like vomiting, chronic diarrhea, mucous bloody diarrhea and hematemesis. More unusual symptoms associated with CMPSE are infantile colic, gastroesophageal reflux and chronic constipation. The objective of this study was to assess the gastrointestinal manifestations and allergic march in CMPSE patients. METHOD: The authors reviewed the records of 10 CMPSE patients observed by the Gastrointestinal Unit at King Chulalongkorn Memorial Hospital from 1997-2001 including patient characteristics, laboratory investigations, endoscopy and follow-up outcome. RESULTS: Of 10 CMPSE patients, the median age of CMPSE onset was 3.5 months. The gastrointestinal manifestations were hematemesis (n = 6), mucous bloody diarrhea (n = 3) and chronic watery diarrhea (n = 2). Exclusively breast-fed infants seemed to have more delayed onset of symptoms than those who were not. Anemia (n = 3), high serum IgE (n = 4) and positive skin prick test for cow's milk (n = 5) were found. Neither peripheral eosinophilia nor hypoalbuminemia was found. Endoscopy revealed acute and chronic gastritis. Treatment was successful by changing to soy or extensive hydrolysate formula with mean duration of cow's milk intolerance of 24 months. In 2-year follow-up, three of ten patients who had high serum IgE level developed allergic rhinitis and eczema. CONCLUSION: CMPSE can be manifested in various symptoms. Exclusive breast feeding for more than 4 months can postpone the onset of CMPSE. Serum IgE or specific IgE level to cow's milk protein may identify the atopic career of CMPSE individuals. SN - 0125-2208 UR - https://www.unboundmedicine.com/medline/citation/12678148/Gastrointestinal_manifestations_of_cow's_milk_protein_allergy_during_the_first_year_of_life_ DB - PRIME DP - Unbound Medicine ER -