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Bioassay-guided isolation of antimutagenic factors from fruits of Terminalia bellerica.
J Environ Pathol Toxicol Oncol. 2003; 22(1):69-76.JE

Abstract

In the course of our search for novel polyphenolic antimutagenic agents from medicinal plants, we examined water, acetone, and chloroform extracts of Terminalia bellerica for their antimutagenic potency using the Ames Salmonella/microsome assay. Acetone extract exhibited variable inhibitory activity of 65.6%, and 69.7% with 4-O-nitrophenylenediamine (NPD) and sodium azide, respectively (as direct-acting mutagens), and 81.4% with 2-aminofluorene (2AF) (an S9-dependent mutagen), in the preincubation mode of experimentation. Inhibition with chloroform and water extracts was rather insignificant. Studies are well underway to isolate and identify the active polyphenolic compounds from acetone extract, which could be used as effective chemopreventive agents in the future.

Authors+Show Affiliations

Kaur S
Department of Botanical Sciences, Guru Nanak Dev University, Amritsar, India. swayamk@yahoo.com
Arora S
No affiliation info available
Kaur S
No affiliation info available
Kumar S
No affiliation info available

MeSH

Antimutagenic AgentsBiological AssayDNA DamageFruitMicrosomesMutagenicity TestsPhenolsPlant ExtractsPlant PreparationsSalmonellaTerminalia

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12678407

Citation

Kaur, Swayamjot, et al. "Bioassay-guided Isolation of Antimutagenic Factors From Fruits of Terminalia Bellerica." Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer, vol. 22, no. 1, 2003, pp. 69-76.
Kaur S, Arora S, Kaur S, et al. Bioassay-guided isolation of antimutagenic factors from fruits of Terminalia bellerica. J Environ Pathol Toxicol Oncol. 2003;22(1):69-76.
Kaur, S., Arora, S., Kaur, S., & Kumar, S. (2003). Bioassay-guided isolation of antimutagenic factors from fruits of Terminalia bellerica. Journal of Environmental Pathology, Toxicology and Oncology : Official Organ of the International Society for Environmental Toxicology and Cancer, 22(1), 69-76.
Kaur S, et al. Bioassay-guided Isolation of Antimutagenic Factors From Fruits of Terminalia Bellerica. J Environ Pathol Toxicol Oncol. 2003;22(1):69-76. PubMed PMID: 12678407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioassay-guided isolation of antimutagenic factors from fruits of Terminalia bellerica. AU - Kaur,Swayamjot, AU - Arora,Saroj, AU - Kaur,Satwinderjeet, AU - Kumar,Subodh, PY - 2003/4/8/pubmed PY - 2003/4/16/medline PY - 2003/4/8/entrez SP - 69 EP - 76 JF - Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer JO - J Environ Pathol Toxicol Oncol VL - 22 IS - 1 N2 - In the course of our search for novel polyphenolic antimutagenic agents from medicinal plants, we examined water, acetone, and chloroform extracts of Terminalia bellerica for their antimutagenic potency using the Ames Salmonella/microsome assay. Acetone extract exhibited variable inhibitory activity of 65.6%, and 69.7% with 4-O-nitrophenylenediamine (NPD) and sodium azide, respectively (as direct-acting mutagens), and 81.4% with 2-aminofluorene (2AF) (an S9-dependent mutagen), in the preincubation mode of experimentation. Inhibition with chloroform and water extracts was rather insignificant. Studies are well underway to isolate and identify the active polyphenolic compounds from acetone extract, which could be used as effective chemopreventive agents in the future. SN - 0731-8898 UR - https://www.unboundmedicine.com/medline/citation/12678407/Bioassay_guided_isolation_of_antimutagenic_factors_from_fruits_of_Terminalia_bellerica_ DB - PRIME DP - Unbound Medicine ER -