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(R)-Methanandamide and delta9-tetrahydrocannabinol-induced operant rate decreases in rats are not readily antagonized by SR-141716A.
Eur J Pharmacol. 2003 Apr 11; 466(1-2):121-7.EJ

Abstract

The current study examined the interaction between the cannabinoid CB(1) receptor agonists Delta(9)-tetrahydrocannabinol and (R)-methanandamide in combination with the cannabinoid CB(1) receptor antagonist SR-141716A (N-(piperidin-1-yl)-5-(4-chloro-phenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide HCl) in rats responding for food on a fixed ratio (FR-10) schedule of food reinforcement. The study provided only limited evidence for antagonism by SR-141716A (at 1 mg/kg but not with 0.3, 3 and 10 mg/kg) of the rate suppressant effects induced by the cannabinoid CB(1) receptor agonist Delta(9)-tetrahydrocannabinol (and only at the single dose of 5.6 mg/kg Delta(9)-tetrahydrocannabinol). (R)-Methanandamide in combination with SR-141716A resulted in a greater rate suppression compared to that induced by (R)-methanandamide alone. Thus, SR-141716A augmented the rate-decreasing effects of (R)-methanandamide and only minimally altered the rate-decreasing effects of Delta(9)-tetrahydrocannabinol. Additionally, high doses (10 and 30 mg/kg) of SR-141716 singly consistently suppressed the rate of responding. The current results coupled with our previous data examining combinations of Delta(9)-tetrahydrocannabinol or (R)-methanandamide and SR-141716 (see text) underscore pharmacological/behavioral differences (whether quantitative or qualitative) between the cannabinoid CB(1) agonists (R)-methanandamide and Delta(9)-tetrahydrocannabinol revealed by their interactions with the cannabinoid CB(1) antagonist SR-141716.

Authors+Show Affiliations

Department of Psychiatry, MCP Hahnemann University, Philadelphia, PA 19102, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12679148

Citation

Järbe, Torbjörn U C., et al. "(R)-Methanandamide and Delta9-tetrahydrocannabinol-induced Operant Rate Decreases in Rats Are Not Readily Antagonized By SR-141716A." European Journal of Pharmacology, vol. 466, no. 1-2, 2003, pp. 121-7.
Järbe TU, Lamb RJ, Liu Q, et al. (R)-Methanandamide and delta9-tetrahydrocannabinol-induced operant rate decreases in rats are not readily antagonized by SR-141716A. Eur J Pharmacol. 2003;466(1-2):121-7.
Järbe, T. U., Lamb, R. J., Liu, Q., & Makriyannis, A. (2003). (R)-Methanandamide and delta9-tetrahydrocannabinol-induced operant rate decreases in rats are not readily antagonized by SR-141716A. European Journal of Pharmacology, 466(1-2), 121-7.
Järbe TU, et al. (R)-Methanandamide and Delta9-tetrahydrocannabinol-induced Operant Rate Decreases in Rats Are Not Readily Antagonized By SR-141716A. Eur J Pharmacol. 2003 Apr 11;466(1-2):121-7. PubMed PMID: 12679148.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - (R)-Methanandamide and delta9-tetrahydrocannabinol-induced operant rate decreases in rats are not readily antagonized by SR-141716A. AU - Järbe,Torbjörn U C, AU - Lamb,Richard J, AU - Liu,Qian, AU - Makriyannis,Alexandros, PY - 2003/4/8/pubmed PY - 2004/3/9/medline PY - 2003/4/8/entrez SP - 121 EP - 7 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 466 IS - 1-2 N2 - The current study examined the interaction between the cannabinoid CB(1) receptor agonists Delta(9)-tetrahydrocannabinol and (R)-methanandamide in combination with the cannabinoid CB(1) receptor antagonist SR-141716A (N-(piperidin-1-yl)-5-(4-chloro-phenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide HCl) in rats responding for food on a fixed ratio (FR-10) schedule of food reinforcement. The study provided only limited evidence for antagonism by SR-141716A (at 1 mg/kg but not with 0.3, 3 and 10 mg/kg) of the rate suppressant effects induced by the cannabinoid CB(1) receptor agonist Delta(9)-tetrahydrocannabinol (and only at the single dose of 5.6 mg/kg Delta(9)-tetrahydrocannabinol). (R)-Methanandamide in combination with SR-141716A resulted in a greater rate suppression compared to that induced by (R)-methanandamide alone. Thus, SR-141716A augmented the rate-decreasing effects of (R)-methanandamide and only minimally altered the rate-decreasing effects of Delta(9)-tetrahydrocannabinol. Additionally, high doses (10 and 30 mg/kg) of SR-141716 singly consistently suppressed the rate of responding. The current results coupled with our previous data examining combinations of Delta(9)-tetrahydrocannabinol or (R)-methanandamide and SR-141716 (see text) underscore pharmacological/behavioral differences (whether quantitative or qualitative) between the cannabinoid CB(1) agonists (R)-methanandamide and Delta(9)-tetrahydrocannabinol revealed by their interactions with the cannabinoid CB(1) antagonist SR-141716. SN - 0014-2999 UR - https://www.unboundmedicine.com/medline/citation/12679148/_R__Methanandamide_and_delta9_tetrahydrocannabinol_induced_operant_rate_decreases_in_rats_are_not_readily_antagonized_by_SR_141716A_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014299903014912 DB - PRIME DP - Unbound Medicine ER -