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Circulating concentration of adiponectin and its expression in subcutaneous adipose tissue in patients with highly active antiretroviral therapy-associated lipodystrophy.
J Clin Endocrinol Metab. 2003 Apr; 88(4):1907-10.JC

Abstract

Highly active antiretroviral therapy (HAART) has dramatically reduced HIV-related mortality, but is associated with severe metabolic adverse events, such as lipodystrophy and insulin resistance, the mechanisms of which are unknown. Adiponectin is a adipocytokine that is decreased in insulin resistant conditions. In mice, adiponectin decreases liver and muscle fat content and enhances insulin sensitivity. We determined serum adiponenctin and adiponectin mRNA concentrations in subcutaneous adipose tissue in HIV-positive HAART-treated patients with (HAART+LD+, n = 30) and without lipodystrophy (HAART+LD-, n = 13). The HAART+ LD+ group had significantly less subcutaneous and more intra-abdominal fat than the HAART+LD- group. Liver fat content (spectroscopy), serum insulin, C-peptide and triglyceride concentrations were significantly higher, and HDL cholesterol concentration lower in the HAART+LD+ than the HAART+LD- group. Serum adiponectin (3.4 +/- 0.4 vs 8.5 +/- 1.0 micro g/mL, p < 0.001) and adiponectin mRNA concentration in subcutaneous adipose tissue (7 +/- 1 x 10(-4) vs 24 +/- 6 x 10(-4), p < 0.001) were significantly lower in the HAART+LD+ than the HAART+LD- group. Both serum adiponectin and mRNA concentrations correlated closely with features of insulin resistance, including liver fat content. These data suggest that the decreased production of adiponectin in lipoatrophic adipose tissue may contribute to hepatic insulin resistance in these patients.

Authors+Show Affiliations

Department of Medicine, Division of Diabetes, Helsinki University Central Hospital, Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12679491

Citation

Sutinen, Jussi, et al. "Circulating Concentration of Adiponectin and Its Expression in Subcutaneous Adipose Tissue in Patients With Highly Active Antiretroviral Therapy-associated Lipodystrophy." The Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 4, 2003, pp. 1907-10.
Sutinen J, Korsheninnikova E, Funahashi T, et al. Circulating concentration of adiponectin and its expression in subcutaneous adipose tissue in patients with highly active antiretroviral therapy-associated lipodystrophy. J Clin Endocrinol Metab. 2003;88(4):1907-10.
Sutinen, J., Korsheninnikova, E., Funahashi, T., Matsuzawa, Y., Nyman, T., & Yki-Järvinen, H. (2003). Circulating concentration of adiponectin and its expression in subcutaneous adipose tissue in patients with highly active antiretroviral therapy-associated lipodystrophy. The Journal of Clinical Endocrinology and Metabolism, 88(4), 1907-10.
Sutinen J, et al. Circulating Concentration of Adiponectin and Its Expression in Subcutaneous Adipose Tissue in Patients With Highly Active Antiretroviral Therapy-associated Lipodystrophy. J Clin Endocrinol Metab. 2003;88(4):1907-10. PubMed PMID: 12679491.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating concentration of adiponectin and its expression in subcutaneous adipose tissue in patients with highly active antiretroviral therapy-associated lipodystrophy. AU - Sutinen,Jussi, AU - Korsheninnikova,Elena, AU - Funahashi,Tohru, AU - Matsuzawa,Yuji, AU - Nyman,Tuulikki, AU - Yki-Järvinen,Hannele, PY - 2003/4/8/pubmed PY - 2003/5/13/medline PY - 2003/4/8/entrez SP - 1907 EP - 10 JF - The Journal of clinical endocrinology and metabolism JO - J. Clin. Endocrinol. Metab. VL - 88 IS - 4 N2 - Highly active antiretroviral therapy (HAART) has dramatically reduced HIV-related mortality, but is associated with severe metabolic adverse events, such as lipodystrophy and insulin resistance, the mechanisms of which are unknown. Adiponectin is a adipocytokine that is decreased in insulin resistant conditions. In mice, adiponectin decreases liver and muscle fat content and enhances insulin sensitivity. We determined serum adiponenctin and adiponectin mRNA concentrations in subcutaneous adipose tissue in HIV-positive HAART-treated patients with (HAART+LD+, n = 30) and without lipodystrophy (HAART+LD-, n = 13). The HAART+ LD+ group had significantly less subcutaneous and more intra-abdominal fat than the HAART+LD- group. Liver fat content (spectroscopy), serum insulin, C-peptide and triglyceride concentrations were significantly higher, and HDL cholesterol concentration lower in the HAART+LD+ than the HAART+LD- group. Serum adiponectin (3.4 +/- 0.4 vs 8.5 +/- 1.0 micro g/mL, p < 0.001) and adiponectin mRNA concentration in subcutaneous adipose tissue (7 +/- 1 x 10(-4) vs 24 +/- 6 x 10(-4), p < 0.001) were significantly lower in the HAART+LD+ than the HAART+LD- group. Both serum adiponectin and mRNA concentrations correlated closely with features of insulin resistance, including liver fat content. These data suggest that the decreased production of adiponectin in lipoatrophic adipose tissue may contribute to hepatic insulin resistance in these patients. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/12679491/Circulating_concentration_of_adiponectin_and_its_expression_in_subcutaneous_adipose_tissue_in_patients_with_highly_active_antiretroviral_therapy_associated_lipodystrophy_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2002-021922 DB - PRIME DP - Unbound Medicine ER -