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Down-regulated expression of the CCAAT/enhancer binding protein alpha and beta genes in human hepatocellular carcinoma: a possible prognostic marker.
Anticancer Res. 2003 Jan-Feb; 23(1A):351-4.AR

Abstract

CCAAT/enhancer binding protein alpha (C/EBP alpha) and C/EBP beta, liver specific transcription factors, are involved in hepatocyte proliferation and differentiation. The expression level of the C/EBP alpha and C/EBP beta genes were examined between tumor and non-tumorous tissues of the same hepatocellular carcinoma patients with quantitative real-time polymerase chain reactions. The expression of both the C/EBP alpha and C/EBP beta genes was down-regulated in the majority of the tumor specimens compared with corresponding non-tumorous tissues. Patients whose expression of either C/EBP alpha or C/EBP beta was higher in tumors than non-tumorous tissues survived longer than those whose expression was lower in tumors. Higher expression of C/EBP alpha or C/EBP beta in tumors was reversibly correlated with the tumor size and progression of the clinical stage. These data imply that the comparison of C/EBP alpha and C/EBP beta expression between tumors and non-tumorous regions could be a prognostic marker for patients with hepatocellular carcinoma.

Authors+Show Affiliations

Division of Pathology, Chiba Cancer Center Research Institute, Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan. nihminor-cib@umin.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12680236

Citation

Tomizawa, Minoru, et al. "Down-regulated Expression of the CCAAT/enhancer Binding Protein Alpha and Beta Genes in Human Hepatocellular Carcinoma: a Possible Prognostic Marker." Anticancer Research, vol. 23, no. 1A, 2003, pp. 351-4.
Tomizawa M, Watanabe K, Saisho H, et al. Down-regulated expression of the CCAAT/enhancer binding protein alpha and beta genes in human hepatocellular carcinoma: a possible prognostic marker. Anticancer Res. 2003;23(1A):351-4.
Tomizawa, M., Watanabe, K., Saisho, H., Nakagawara, A., & Tagawa, M. (2003). Down-regulated expression of the CCAAT/enhancer binding protein alpha and beta genes in human hepatocellular carcinoma: a possible prognostic marker. Anticancer Research, 23(1A), 351-4.
Tomizawa M, et al. Down-regulated Expression of the CCAAT/enhancer Binding Protein Alpha and Beta Genes in Human Hepatocellular Carcinoma: a Possible Prognostic Marker. Anticancer Res. 2003 Jan-Feb;23(1A):351-4. PubMed PMID: 12680236.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Down-regulated expression of the CCAAT/enhancer binding protein alpha and beta genes in human hepatocellular carcinoma: a possible prognostic marker. AU - Tomizawa,Minoru, AU - Watanabe,Kazuo, AU - Saisho,Hiromitsu, AU - Nakagawara,Akira, AU - Tagawa,Masatoshi, PY - 2003/4/12/pubmed PY - 2003/5/2/medline PY - 2003/4/12/entrez SP - 351 EP - 4 JF - Anticancer research JO - Anticancer Res VL - 23 IS - 1A N2 - CCAAT/enhancer binding protein alpha (C/EBP alpha) and C/EBP beta, liver specific transcription factors, are involved in hepatocyte proliferation and differentiation. The expression level of the C/EBP alpha and C/EBP beta genes were examined between tumor and non-tumorous tissues of the same hepatocellular carcinoma patients with quantitative real-time polymerase chain reactions. The expression of both the C/EBP alpha and C/EBP beta genes was down-regulated in the majority of the tumor specimens compared with corresponding non-tumorous tissues. Patients whose expression of either C/EBP alpha or C/EBP beta was higher in tumors than non-tumorous tissues survived longer than those whose expression was lower in tumors. Higher expression of C/EBP alpha or C/EBP beta in tumors was reversibly correlated with the tumor size and progression of the clinical stage. These data imply that the comparison of C/EBP alpha and C/EBP beta expression between tumors and non-tumorous regions could be a prognostic marker for patients with hepatocellular carcinoma. SN - 0250-7005 UR - https://www.unboundmedicine.com/medline/citation/12680236/Down_regulated_expression_of_the_CCAAT/enhancer_binding_protein_alpha_and_beta_genes_in_human_hepatocellular_carcinoma:_a_possible_prognostic_marker_ L2 - https://medlineplus.gov/livercancer.html DB - PRIME DP - Unbound Medicine ER -