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Mattress encasings and mite allergen levels in the Prevention and Incidence of Asthma and Mite Allergy study.
Clin Exp Allergy 2003; 33(4):490-5CE

Abstract

BACKGROUND

Reduction of allergen exposure from birth may reduce sensitization and subsequent allergic disease.

OBJECTIVE

To measure the influence of mite allergen-impermeable mattress encasings and cotton placebo encasings on the amount of dust and mite allergen in beds.

METHODS

A total of 810 children with allergic mothers took part in the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) study. Allergen-impermeable and placebo mattress encasings were applied to the childrens' and the parents' beds before birth. Dust samples were taken from the beds of children and their parents before birth and 3 and 12 months after birth. Extracts of dust samples were analysed for mite allergens (Der p 1 and Der f 1).

RESULTS

Active mattress encasings were significantly more effective in reducing dust and mite allergen levels than placebo encasings. Mite allergen levels were low in general and the treatment effect was modest. Twelve months after birth, mattresses with active mattress encasings had about half the amount of Der 1 (Der p 1 + Der f 1)/m2, compared to mattresses with placebo encasings, for the child's and the parental mattress.

CONCLUSION

This study shows that mite-impermeable mattress encasings have a significant but modest effect on dust and mite allergen levels of mattresses with low initial mite allergen levels, compared to placebo.

Authors+Show Affiliations

Department of Environmental and Occupational Health, Institute for Risk Assessment Sciences, Utrecht, the Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12680865

Citation

van Strien, R T., et al. "Mattress Encasings and Mite Allergen Levels in the Prevention and Incidence of Asthma and Mite Allergy Study." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 33, no. 4, 2003, pp. 490-5.
van Strien RT, Koopman LP, Kerkhof M, et al. Mattress encasings and mite allergen levels in the Prevention and Incidence of Asthma and Mite Allergy study. Clin Exp Allergy. 2003;33(4):490-5.
van Strien, R. T., Koopman, L. P., Kerkhof, M., Oldenwening, M., de Jongste, J. C., Gerritsen, J., ... Brunekreef, B. (2003). Mattress encasings and mite allergen levels in the Prevention and Incidence of Asthma and Mite Allergy study. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 33(4), pp. 490-5.
van Strien RT, et al. Mattress Encasings and Mite Allergen Levels in the Prevention and Incidence of Asthma and Mite Allergy Study. Clin Exp Allergy. 2003;33(4):490-5. PubMed PMID: 12680865.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mattress encasings and mite allergen levels in the Prevention and Incidence of Asthma and Mite Allergy study. AU - van Strien,R T, AU - Koopman,L P, AU - Kerkhof,M, AU - Oldenwening,M, AU - de Jongste,J C, AU - Gerritsen,J, AU - Neijens,H J, AU - Aalberse,R C, AU - Smit,H A, AU - Brunekreef,B, AU - ,, PY - 2003/4/16/pubmed PY - 2003/7/23/medline PY - 2003/4/16/entrez SP - 490 EP - 5 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin. Exp. Allergy VL - 33 IS - 4 N2 - BACKGROUND: Reduction of allergen exposure from birth may reduce sensitization and subsequent allergic disease. OBJECTIVE: To measure the influence of mite allergen-impermeable mattress encasings and cotton placebo encasings on the amount of dust and mite allergen in beds. METHODS: A total of 810 children with allergic mothers took part in the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) study. Allergen-impermeable and placebo mattress encasings were applied to the childrens' and the parents' beds before birth. Dust samples were taken from the beds of children and their parents before birth and 3 and 12 months after birth. Extracts of dust samples were analysed for mite allergens (Der p 1 and Der f 1). RESULTS: Active mattress encasings were significantly more effective in reducing dust and mite allergen levels than placebo encasings. Mite allergen levels were low in general and the treatment effect was modest. Twelve months after birth, mattresses with active mattress encasings had about half the amount of Der 1 (Der p 1 + Der f 1)/m2, compared to mattresses with placebo encasings, for the child's and the parental mattress. CONCLUSION: This study shows that mite-impermeable mattress encasings have a significant but modest effect on dust and mite allergen levels of mattresses with low initial mite allergen levels, compared to placebo. SN - 0954-7894 UR - https://www.unboundmedicine.com/medline/citation/12680865/Mattress_encasings_and_mite_allergen_levels_in_the_Prevention_and_Incidence_of_Asthma_and_Mite_Allergy_study_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0954-7894&date=2003&volume=33&issue=4&spage=490 DB - PRIME DP - Unbound Medicine ER -