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A familial abnormality of circulating vitamin B12 binding proteins: occurrence in a family of high serum concentrations of transcobalamin II.
Br J Haematol. 1976 Jun; 33(2):249-59.BJ

Abstract

A family is described in which two members (a father and a daughter), both with quiescent ulcerative colitis, had abnormally high serum concentrations of a vitamin B12 binding protein. This protein had the molecular weight of transcobalamin II on gel filtration, and behaved like transcobalamin II with respect to its elution from DE-23 cellulose, its inhibition at acid pH, its absorption by uncoated charcoal, its binding by anti-TC II antibodies, and its ability to transfer vitamin B12 to transformed lymphocytes. Its plasma clearance and tissue distribution when injected into rabbits was indistinguishable from that of transcobalamin II from normal subjects. It migrated on electrophoresis in the beta, gamma region. This is the first case report of related subjects in whom high serum concentrations of transcobalamin II have been observed.

Authors

Kane SP
No affiliation info available
Hoffbrand AV
No affiliation info available
Allen RH
No affiliation info available
Neale G
No affiliation info available

MeSH

Blood ProteinsCarrier ProteinsHumansLymphocytesMaleMetabolism, Inborn ErrorsMiddle AgedTranscobalaminsVitamin B 12

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

1268096

Citation

Kane, S P., et al. "A Familial Abnormality of Circulating Vitamin B12 Binding Proteins: Occurrence in a Family of High Serum Concentrations of Transcobalamin II." British Journal of Haematology, vol. 33, no. 2, 1976, pp. 249-59.
Kane SP, Hoffbrand AV, Allen RH, et al. A familial abnormality of circulating vitamin B12 binding proteins: occurrence in a family of high serum concentrations of transcobalamin II. Br J Haematol. 1976;33(2):249-59.
Kane, S. P., Hoffbrand, A. V., Allen, R. H., & Neale, G. (1976). A familial abnormality of circulating vitamin B12 binding proteins: occurrence in a family of high serum concentrations of transcobalamin II. British Journal of Haematology, 33(2), 249-59.
Kane SP, et al. A Familial Abnormality of Circulating Vitamin B12 Binding Proteins: Occurrence in a Family of High Serum Concentrations of Transcobalamin II. Br J Haematol. 1976;33(2):249-59. PubMed PMID: 1268096.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A familial abnormality of circulating vitamin B12 binding proteins: occurrence in a family of high serum concentrations of transcobalamin II. AU - Kane,S P, AU - Hoffbrand,A V, AU - Allen,R H, AU - Neale,G, PY - 1976/6/1/pubmed PY - 1976/6/1/medline PY - 1976/6/1/entrez SP - 249 EP - 59 JF - British journal of haematology JO - Br J Haematol VL - 33 IS - 2 N2 - A family is described in which two members (a father and a daughter), both with quiescent ulcerative colitis, had abnormally high serum concentrations of a vitamin B12 binding protein. This protein had the molecular weight of transcobalamin II on gel filtration, and behaved like transcobalamin II with respect to its elution from DE-23 cellulose, its inhibition at acid pH, its absorption by uncoated charcoal, its binding by anti-TC II antibodies, and its ability to transfer vitamin B12 to transformed lymphocytes. Its plasma clearance and tissue distribution when injected into rabbits was indistinguishable from that of transcobalamin II from normal subjects. It migrated on electrophoresis in the beta, gamma region. This is the first case report of related subjects in whom high serum concentrations of transcobalamin II have been observed. SN - 0007-1048 UR - https://www.unboundmedicine.com/medline/citation/1268096/A_familial_abnormality_of_circulating_vitamin_B12_binding_proteins:_occurrence_in_a_family_of_high_serum_concentrations_of_transcobalamin_II_ DB - PRIME DP - Unbound Medicine ER -