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Vaccine development for capsulate bacteria causing pneumonia.
Curr Opin Pulm Med. 2003 May; 9(3):227-32.CO

Abstract

Pneumonia strikes the extremes of the age spectrum, causing maximal death and disability in children and the elderly. Despite its worldwide impact, there is a paucity of epidemiologic data regarding its incidence and the causative organisms. The two leading causes of bacterial pneumonia in childhood are Streptococcus pneumoniae (SP) and Haemophilus influenzae type b (Hib). SP is the major cause of pneumonia beyond the newborn period. In neonates, Group B Streptococcus (GBS) remains a major cause of sepsis and pneumonia despite recent reductions due to targeted perinatal antibiotic prophylaxis. Hib vaccine can prevent pneumonia in developing countries. SP conjugate vaccine prevents X-ray confirmed pneumonia in low incident populations, but protection appears more marginal in high incident populations. Non-vaccine SP serotypes have demonstrated increased carriage and mucosal disease, but not invasive disease following vaccination. GBS vaccines are in the early stages of clinical development as prenatal or antenatal vaccines.

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Authors+Show Affiliations

Russell FM
Centre for International Child Health, and Murdoch Childrens Research Institute, Royal Children's Hospital, Department of Paediatrics, University of Melbourne, Parkville, Melbourne, Australia.
Buttery J
No affiliation info available

MeSH

Bacterial CapsulesBacterial VaccinesChildChild, PreschoolFemaleHaemophilus InfectionsHaemophilus VaccinesHumansIncidenceMalePneumococcal VaccinesPneumonia, PneumococcalPneumonia, StaphylococcalPolysaccharides, BacterialRisk FactorsSensitivity and SpecificitySurvival RateVaccines, Conjugate

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12682569

Citation

Russell, Fiona Mary, and Jim Buttery. "Vaccine Development for Capsulate Bacteria Causing Pneumonia." Current Opinion in Pulmonary Medicine, vol. 9, no. 3, 2003, pp. 227-32.
Russell FM, Buttery J. Vaccine development for capsulate bacteria causing pneumonia. Curr Opin Pulm Med. 2003;9(3):227-32.
Russell, F. M., & Buttery, J. (2003). Vaccine development for capsulate bacteria causing pneumonia. Current Opinion in Pulmonary Medicine, 9(3), 227-32.
Russell FM, Buttery J. Vaccine Development for Capsulate Bacteria Causing Pneumonia. Curr Opin Pulm Med. 2003;9(3):227-32. PubMed PMID: 12682569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vaccine development for capsulate bacteria causing pneumonia. AU - Russell,Fiona Mary, AU - Buttery,Jim, PY - 2003/4/12/pubmed PY - 2003/7/24/medline PY - 2003/4/12/entrez SP - 227 EP - 32 JF - Current opinion in pulmonary medicine JO - Curr Opin Pulm Med VL - 9 IS - 3 N2 - Pneumonia strikes the extremes of the age spectrum, causing maximal death and disability in children and the elderly. Despite its worldwide impact, there is a paucity of epidemiologic data regarding its incidence and the causative organisms. The two leading causes of bacterial pneumonia in childhood are Streptococcus pneumoniae (SP) and Haemophilus influenzae type b (Hib). SP is the major cause of pneumonia beyond the newborn period. In neonates, Group B Streptococcus (GBS) remains a major cause of sepsis and pneumonia despite recent reductions due to targeted perinatal antibiotic prophylaxis. Hib vaccine can prevent pneumonia in developing countries. SP conjugate vaccine prevents X-ray confirmed pneumonia in low incident populations, but protection appears more marginal in high incident populations. Non-vaccine SP serotypes have demonstrated increased carriage and mucosal disease, but not invasive disease following vaccination. GBS vaccines are in the early stages of clinical development as prenatal or antenatal vaccines. SN - 1070-5287 UR - https://www.unboundmedicine.com/medline/citation/12682569/Vaccine_development_for_capsulate_bacteria_causing_pneumonia_ L2 - https://doi.org/10.1097/00063198-200305000-00012 DB - PRIME DP - Unbound Medicine ER -