Tags

Type your tag names separated by a space and hit enter

Decreased plasma concentration of nitric oxide metabolites in dogs with untreated mitral regurgitation.
J Vet Intern Med. 2003 Mar-Apr; 17(2):178-84.JV

Abstract

Endothelium-dependent (nitric oxide [NO]-mediated) vasodilation is impaired in humans with heart failure. This dysfunction is an important therapeutic target. The plasma concentration of the NO metabolites nitrate and nitrite (collectively referred to as NOx) is a measure of whole-body NO production, provided that the dietary intake of the ions is low. Fifty clinically healthy dogs older than I year (median 5.0 years; interquartile interval 2.6-8.2 years) were studied, including 9 controls of various breeds, 23 Cavalier King Charles Spaniels (CKCSs) with no or minimal mitral regurgitation (MR), 9 CKCSs with mild MR (regurgitant jet occupying 15-50% of the left atrial area), and 9 CKCS with moderate to severe MR (jet >50%) due to myxomatous valve disease. None of the dogs received medication. The dogs were given NOx-free water and a diet with a low concentration of NOx for 96 hours before blood sampling. Multiple linear regression analysis revealed that dog group, but not gender, age, serum creatinine concentration, and platelet count, was associated with NOx concentrations. Control dogs had the same NOx concentration (median 20.0 microM; interquartile interval 15.1-25.5 microM) as CKCSs without MR (median 18.7 microM; interquartile interval 15.5-25.9 microM). Compared to CKCSs without MR, the NOx concentration was lower in CKCSs with mild (median 12.9 microM; interquartile interval 11.0-13.5 microM; P = .04) and moderate to severe (median 11.2 microM; interquartile interval 6.9-17.1 microM; P = .02) MR. In conclusion, CKCSs with mild to severe, clinically silent MR have decreased plasma NOx concentrations, suggesting that endothelial dysfunction develops early in the course of developing MR in dogs.

Authors+Show Affiliations

Department of Anatomy and Physiology, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark. hdp@kvl.dkNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12683618

Citation

Pedersen, Henrik D., et al. "Decreased Plasma Concentration of Nitric Oxide Metabolites in Dogs With Untreated Mitral Regurgitation." Journal of Veterinary Internal Medicine, vol. 17, no. 2, 2003, pp. 178-84.
Pedersen HD, Schütt T, Søndergaard R, et al. Decreased plasma concentration of nitric oxide metabolites in dogs with untreated mitral regurgitation. J Vet Intern Med. 2003;17(2):178-84.
Pedersen, H. D., Schütt, T., Søndergaard, R., Qvortrup, K., Olsen, L. H., & Kristensen, A. T. (2003). Decreased plasma concentration of nitric oxide metabolites in dogs with untreated mitral regurgitation. Journal of Veterinary Internal Medicine, 17(2), 178-84.
Pedersen HD, et al. Decreased Plasma Concentration of Nitric Oxide Metabolites in Dogs With Untreated Mitral Regurgitation. J Vet Intern Med. 2003 Mar-Apr;17(2):178-84. PubMed PMID: 12683618.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Decreased plasma concentration of nitric oxide metabolites in dogs with untreated mitral regurgitation. AU - Pedersen,Henrik D, AU - Schütt,Trine, AU - Søndergaard,Rikke, AU - Qvortrup,Karen, AU - Olsen,Lisbeth H, AU - Kristensen,Annemarie T, PY - 2003/4/10/pubmed PY - 2003/5/24/medline PY - 2003/4/10/entrez SP - 178 EP - 84 JF - Journal of veterinary internal medicine JO - J. Vet. Intern. Med. VL - 17 IS - 2 N2 - Endothelium-dependent (nitric oxide [NO]-mediated) vasodilation is impaired in humans with heart failure. This dysfunction is an important therapeutic target. The plasma concentration of the NO metabolites nitrate and nitrite (collectively referred to as NOx) is a measure of whole-body NO production, provided that the dietary intake of the ions is low. Fifty clinically healthy dogs older than I year (median 5.0 years; interquartile interval 2.6-8.2 years) were studied, including 9 controls of various breeds, 23 Cavalier King Charles Spaniels (CKCSs) with no or minimal mitral regurgitation (MR), 9 CKCSs with mild MR (regurgitant jet occupying 15-50% of the left atrial area), and 9 CKCS with moderate to severe MR (jet >50%) due to myxomatous valve disease. None of the dogs received medication. The dogs were given NOx-free water and a diet with a low concentration of NOx for 96 hours before blood sampling. Multiple linear regression analysis revealed that dog group, but not gender, age, serum creatinine concentration, and platelet count, was associated with NOx concentrations. Control dogs had the same NOx concentration (median 20.0 microM; interquartile interval 15.1-25.5 microM) as CKCSs without MR (median 18.7 microM; interquartile interval 15.5-25.9 microM). Compared to CKCSs without MR, the NOx concentration was lower in CKCSs with mild (median 12.9 microM; interquartile interval 11.0-13.5 microM; P = .04) and moderate to severe (median 11.2 microM; interquartile interval 6.9-17.1 microM; P = .02) MR. In conclusion, CKCSs with mild to severe, clinically silent MR have decreased plasma NOx concentrations, suggesting that endothelial dysfunction develops early in the course of developing MR in dogs. SN - 0891-6640 UR - https://www.unboundmedicine.com/medline/citation/12683618/Decreased_plasma_concentration_of_nitric_oxide_metabolites_in_dogs_with_untreated_mitral_regurgitation_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0891-6640&date=2003&volume=17&issue=2&spage=178 DB - PRIME DP - Unbound Medicine ER -