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Lewy body densities in the entorhinal and anterior cingulate cortex predict cognitive deficits in Parkinson's disease.
Acta Neuropathol. 2003 Jul; 106(1):83-8.AN

Abstract

Previous studies reported an association between cortical Lewy body (LB) formation and dementia in Parkinson's disease (PD). However, it is unclear whether cognitive decline in this disorder is related to specific patterns of LB distribution within the cerebral cortex. Moreover, the prediction of cognitive status based on concomitant assessment of LB and Alzheimer's disease lesions has led to conflicting results. We performed a clinicopathological study in 22 elderly PD patients in whom parkinsonism preceded cognitive decline by at least 3 years. Cognitive status was assessed prospectively using the clinical dementia rating scale (CDR); quantitative assessment of LB, neurofibrillary tangles (NFT), and senile plaques (SP) was performed in Brodmann areas 9, 21, 24, 40 and the entorhinal cortex. Statistical analysis was performed using both correlation coefficients and logistic regression models. There was a highly significant correlation between CDR scores and regional LB scores in the entorhinal cortex and area 24. LB and SP densities in the entorhinal cortex accounted for 36.2% and 19.3% of the variability in CDR scores. LB densities in area 24 could explain 25.2% of this variability. NFT densities did not predict cognitive status. In multivariate models only LB densities in the entorhinal cortex and anterior cingulate cortex were significantly associated with CDR scores. These results imply that an assessment of LB pathology limited to the entorhinal cortex and area 24 may be sufficient to predict cognition in PD. They also suggest that LB formation in limbic areas may be crucial for the development of PD dementia.

Authors+Show Affiliations

Kövari E
Department of Psychiatry, HUG Belle-Idée, University of Geneva School of Medicine, Geneva, Switzerland. Eniko.Kovari@hcuge.ch
Gold G
No affiliation info available
Herrmann FR
No affiliation info available
Canuto A
No affiliation info available
Hof PR
No affiliation info available
Bouras C
No affiliation info available
Giannakopoulos P
No affiliation info available

MeSH

Age DistributionAgedAged, 80 and overCell CountCerebral CortexCognition DisordersDisease ProgressionEntorhinal CortexFemaleHumansLewy BodiesMaleMiddle AgedNerve Tissue ProteinsNeurofibrillary TanglesNeuropsychological TestsParkinson DiseasePlaque, AmyloidPsychiatric Status Rating ScalesRegression AnalysisSexSynucleins

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12687392

Citation

Kövari, Enikö, et al. "Lewy Body Densities in the Entorhinal and Anterior Cingulate Cortex Predict Cognitive Deficits in Parkinson's Disease." Acta Neuropathologica, vol. 106, no. 1, 2003, pp. 83-8.
Kövari E, Gold G, Herrmann FR, et al. Lewy body densities in the entorhinal and anterior cingulate cortex predict cognitive deficits in Parkinson's disease. Acta Neuropathol. 2003;106(1):83-8.
Kövari, E., Gold, G., Herrmann, F. R., Canuto, A., Hof, P. R., Bouras, C., & Giannakopoulos, P. (2003). Lewy body densities in the entorhinal and anterior cingulate cortex predict cognitive deficits in Parkinson's disease. Acta Neuropathologica, 106(1), 83-8.
Kövari E, et al. Lewy Body Densities in the Entorhinal and Anterior Cingulate Cortex Predict Cognitive Deficits in Parkinson's Disease. Acta Neuropathol. 2003;106(1):83-8. PubMed PMID: 12687392.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lewy body densities in the entorhinal and anterior cingulate cortex predict cognitive deficits in Parkinson's disease. AU - Kövari,Enikö, AU - Gold,Gabriel, AU - Herrmann,François R, AU - Canuto,Alessandra, AU - Hof,Patrick R, AU - Bouras,Constantin, AU - Giannakopoulos,Panteleimon, Y1 - 2003/04/10/ PY - 2003/01/15/received PY - 2003/03/10/revised PY - 2003/03/10/accepted PY - 2003/4/11/pubmed PY - 2003/8/12/medline PY - 2003/4/11/entrez SP - 83 EP - 8 JF - Acta neuropathologica JO - Acta Neuropathol VL - 106 IS - 1 N2 - Previous studies reported an association between cortical Lewy body (LB) formation and dementia in Parkinson's disease (PD). However, it is unclear whether cognitive decline in this disorder is related to specific patterns of LB distribution within the cerebral cortex. Moreover, the prediction of cognitive status based on concomitant assessment of LB and Alzheimer's disease lesions has led to conflicting results. We performed a clinicopathological study in 22 elderly PD patients in whom parkinsonism preceded cognitive decline by at least 3 years. Cognitive status was assessed prospectively using the clinical dementia rating scale (CDR); quantitative assessment of LB, neurofibrillary tangles (NFT), and senile plaques (SP) was performed in Brodmann areas 9, 21, 24, 40 and the entorhinal cortex. Statistical analysis was performed using both correlation coefficients and logistic regression models. There was a highly significant correlation between CDR scores and regional LB scores in the entorhinal cortex and area 24. LB and SP densities in the entorhinal cortex accounted for 36.2% and 19.3% of the variability in CDR scores. LB densities in area 24 could explain 25.2% of this variability. NFT densities did not predict cognitive status. In multivariate models only LB densities in the entorhinal cortex and anterior cingulate cortex were significantly associated with CDR scores. These results imply that an assessment of LB pathology limited to the entorhinal cortex and area 24 may be sufficient to predict cognition in PD. They also suggest that LB formation in limbic areas may be crucial for the development of PD dementia. SN - 0001-6322 UR - https://www.unboundmedicine.com/medline/citation/12687392/Lewy_body_densities_in_the_entorhinal_and_anterior_cingulate_cortex_predict_cognitive_deficits_in_Parkinson's_disease_ DB - PRIME DP - Unbound Medicine ER -