Tags

Type your tag names separated by a space and hit enter

Serum cortisol and sex hormone binding globulin (SHBG) levels, body fat distribution and the role of genetic factors in obese females.
Sb Lek. 2002; 103(4):471-5.SL

Abstract

Fasting plasma levels of both cortisol and sex hormone binding globulin (SHBG) in obese women were significantly inversely related to anthropometric characteristics of body fat distribution. It means that a central accumulation of body fat might be partly mediated by cortisol and SHBG levels. Significant within-pair resemblance observed in plasma cortisol level in obese female monozygotic twins suggests an important role of genetic factors in determination of cortisol secretion. However, no within-pair similarities revealed in plasma SHBG concentrations favour a major role of environmental factors in the regulation of plasma SHBG level. On the other hand the twin study supported the role of genetic determinants in changes of both cortisol and SHBG levels in response to energy deficit induced by very low calorie diet (VLCD). The mechanisms controlling baseline levels of cortisol and SHBG apparently differ from those controlling their responses to energy restriction.

Authors+Show Affiliations

Hainer V
Obesity Management Centre, 3rd Department of Internal Medicine, 1st Faculty of Medicine, Charles University, Czech Republic. vhainer@endo.cz
Kunesová M
No affiliation info available
Parízková J
No affiliation info available
Mikulová R
No affiliation info available
Stunkard A
No affiliation info available

MeSH

Adipose TissueAdultAnthropometryBody Mass IndexDiseases in TwinsFemaleHumansHydrocortisoneObesitySex Hormone-Binding GlobulinTwins, Monozygotic

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Twin Study

Language

eng

PubMed ID

12688161

Citation

Hainer, V, et al. "Serum Cortisol and Sex Hormone Binding Globulin (SHBG) Levels, Body Fat Distribution and the Role of Genetic Factors in Obese Females." Sbornik Lekarsky, vol. 103, no. 4, 2002, pp. 471-5.
Hainer V, Kunesová M, Parízková J, et al. Serum cortisol and sex hormone binding globulin (SHBG) levels, body fat distribution and the role of genetic factors in obese females. Sb Lek. 2002;103(4):471-5.
Hainer, V., Kunesová, M., Parízková, J., Mikulová, R., & Stunkard, A. (2002). Serum cortisol and sex hormone binding globulin (SHBG) levels, body fat distribution and the role of genetic factors in obese females. Sbornik Lekarsky, 103(4), 471-5.
Hainer V, et al. Serum Cortisol and Sex Hormone Binding Globulin (SHBG) Levels, Body Fat Distribution and the Role of Genetic Factors in Obese Females. Sb Lek. 2002;103(4):471-5. PubMed PMID: 12688161.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum cortisol and sex hormone binding globulin (SHBG) levels, body fat distribution and the role of genetic factors in obese females. AU - Hainer,V, AU - Kunesová,M, AU - Parízková,J, AU - Mikulová,R, AU - Stunkard,A, PY - 2003/4/12/pubmed PY - 2003/4/30/medline PY - 2003/4/12/entrez SP - 471 EP - 5 JF - Sbornik lekarsky JO - Sb Lek VL - 103 IS - 4 N2 - Fasting plasma levels of both cortisol and sex hormone binding globulin (SHBG) in obese women were significantly inversely related to anthropometric characteristics of body fat distribution. It means that a central accumulation of body fat might be partly mediated by cortisol and SHBG levels. Significant within-pair resemblance observed in plasma cortisol level in obese female monozygotic twins suggests an important role of genetic factors in determination of cortisol secretion. However, no within-pair similarities revealed in plasma SHBG concentrations favour a major role of environmental factors in the regulation of plasma SHBG level. On the other hand the twin study supported the role of genetic determinants in changes of both cortisol and SHBG levels in response to energy deficit induced by very low calorie diet (VLCD). The mechanisms controlling baseline levels of cortisol and SHBG apparently differ from those controlling their responses to energy restriction. SN - 0036-5327 UR - https://www.unboundmedicine.com/medline/citation/12688161/Serum_cortisol_and_sex_hormone_binding_globulin__SHBG__levels_body_fat_distribution_and_the_role_of_genetic_factors_in_obese_females_ DB - PRIME DP - Unbound Medicine ER -

Related Citations

More