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Seasonal variation in copper-mediated low-density lipoprotein oxidation in vitro is related to varying plasma concentration of oxidised lipids in summer and winter.
Free Radic Res 2003; 37(3):341-7FR

Abstract

The seasonal variation of CuCl2-mediated low density lipoprotein (LDL) oxidation (10 microM Cu2+, lag phase, rate of oxidation and maximum absorbance at 234 nm) were measured in 43 men and women on 4-6 occasions (mean 5.7 +/- 0.5) over a 12-month period. The lag phase averaged 52.7 +/- 0.6 min and did not differ by gender. Lag phase and rate of the rapid propagation phase of LDL oxidation showed a sinusoidal pattern over the year (increased and reduced oxidative susceptibility during January and June-July, respectively; both p < 0.001). Changes in plasma alpha-tocopherol, ascorbic acid, lycopene or beta-carotene concentrations did not explain seasonal differences in oxidative susceptibility of LDL in vitro. Nor did plasma lipid content of linoleic acid, the main substrate of lipid peroxidation, vary. However, the amount of hydroperoxy- plus hydroxy-fatty acids in plasma lipids varied according to season (p < 0.024) and was related to the lag phase (r = -0.26, p < 0.001). Seasonal variation in oxidative susceptibility was not significant after adjusting for hydroperoxy- plus hydroxy-fatty acids (p = 0.506). Isolated LDL is more vulnerable to Cu2+-induced lipid peroxidation during the winter and this may be due to the higher amount of oxidised lipids during that period.

Authors+Show Affiliations

Cardiovascular Research, University of Edinburgh, George Square, Edinburgh EH8 9XF, UK. rudolph.riemersma@ed.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12688430

Citation

Riemersma, R A., et al. "Seasonal Variation in Copper-mediated Low-density Lipoprotein Oxidation in Vitro Is Related to Varying Plasma Concentration of Oxidised Lipids in Summer and Winter." Free Radical Research, vol. 37, no. 3, 2003, pp. 341-7.
Riemersma RA, Wilson R, Payne JA, et al. Seasonal variation in copper-mediated low-density lipoprotein oxidation in vitro is related to varying plasma concentration of oxidised lipids in summer and winter. Free Radic Res. 2003;37(3):341-7.
Riemersma, R. A., Wilson, R., Payne, J. A., & Shepherd, M. J. (2003). Seasonal variation in copper-mediated low-density lipoprotein oxidation in vitro is related to varying plasma concentration of oxidised lipids in summer and winter. Free Radical Research, 37(3), pp. 341-7.
Riemersma RA, et al. Seasonal Variation in Copper-mediated Low-density Lipoprotein Oxidation in Vitro Is Related to Varying Plasma Concentration of Oxidised Lipids in Summer and Winter. Free Radic Res. 2003;37(3):341-7. PubMed PMID: 12688430.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Seasonal variation in copper-mediated low-density lipoprotein oxidation in vitro is related to varying plasma concentration of oxidised lipids in summer and winter. AU - Riemersma,R A, AU - Wilson,R, AU - Payne,J A, AU - Shepherd,M J, PY - 2003/4/12/pubmed PY - 2003/9/10/medline PY - 2003/4/12/entrez SP - 341 EP - 7 JF - Free radical research JO - Free Radic. Res. VL - 37 IS - 3 N2 - The seasonal variation of CuCl2-mediated low density lipoprotein (LDL) oxidation (10 microM Cu2+, lag phase, rate of oxidation and maximum absorbance at 234 nm) were measured in 43 men and women on 4-6 occasions (mean 5.7 +/- 0.5) over a 12-month period. The lag phase averaged 52.7 +/- 0.6 min and did not differ by gender. Lag phase and rate of the rapid propagation phase of LDL oxidation showed a sinusoidal pattern over the year (increased and reduced oxidative susceptibility during January and June-July, respectively; both p < 0.001). Changes in plasma alpha-tocopherol, ascorbic acid, lycopene or beta-carotene concentrations did not explain seasonal differences in oxidative susceptibility of LDL in vitro. Nor did plasma lipid content of linoleic acid, the main substrate of lipid peroxidation, vary. However, the amount of hydroperoxy- plus hydroxy-fatty acids in plasma lipids varied according to season (p < 0.024) and was related to the lag phase (r = -0.26, p < 0.001). Seasonal variation in oxidative susceptibility was not significant after adjusting for hydroperoxy- plus hydroxy-fatty acids (p = 0.506). Isolated LDL is more vulnerable to Cu2+-induced lipid peroxidation during the winter and this may be due to the higher amount of oxidised lipids during that period. SN - 1071-5762 UR - https://www.unboundmedicine.com/medline/citation/12688430/Seasonal_variation_in_copper_mediated_low_density_lipoprotein_oxidation_in_vitro_is_related_to_varying_plasma_concentration_of_oxidised_lipids_in_summer_and_winter_ DB - PRIME DP - Unbound Medicine ER -