Tags

Type your tag names separated by a space and hit enter

Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimer's disease.
Neurochem Int. 2003 Aug; 43(3):191-6.NI

Abstract

Matrix metalloproteinases (MMPs) may play a role in the pathophysiology of Alzheimer's disease (AD). MMP-9 and tissue inhibitors of metalloproteinases (TIMPs) are elevated in postmortem brain tissue of AD patients. MMPs and TIMPs are found in neurons, microglia, vascular endothelial cells and leukocytes. The aim of this study was to determine whether circulating levels of MMP-2, MMP-9, TIMP-1 and TIMP-2 are elevated in the plasma of AD patients. We compared AD patients to age- and gender-matched controls as well as to Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS) patients. There was constitutive expression of gelatinase A (MMP-2), and gelatinase B (MMP-9), in all the samples as shown by zymographic analysis. Levels of MMP-9 were significantly (P=0.003) elevated in the plasma of AD patients as compared to controls. Plasma levels of MMP-2, TIMP-1 and TIMP-2 were unchanged. There were no significant changes of MMP-2, MMP-9, TIMP-1 and TIMP-2 levels in PD and ALS samples. TIMP-1 and TIMP-2 were significantly correlated with MMP-9 in the AD patients. ApoE genotyping of plasma samples showed that levels of MMP-2, TIMP-1 and TIMP-2 and MMP-9 were not significantly different between the ApoE subgroups. These findings indicate that circulating levels of MMP-9 are increased in AD and may contribute to disease pathology.

Authors+Show Affiliations

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 525 East 68th Street, Room F-610, New York, NY 10021, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

12689599

Citation

Lorenzl, Stefan, et al. "Increased Plasma Levels of Matrix Metalloproteinase-9 in Patients With Alzheimer's Disease." Neurochemistry International, vol. 43, no. 3, 2003, pp. 191-6.
Lorenzl S, Albers DS, Relkin N, et al. Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimer's disease. Neurochem Int. 2003;43(3):191-6.
Lorenzl, S., Albers, D. S., Relkin, N., Ngyuen, T., Hilgenberg, S. L., Chirichigno, J., Cudkowicz, M. E., & Beal, M. F. (2003). Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimer's disease. Neurochemistry International, 43(3), 191-6.
Lorenzl S, et al. Increased Plasma Levels of Matrix Metalloproteinase-9 in Patients With Alzheimer's Disease. Neurochem Int. 2003;43(3):191-6. PubMed PMID: 12689599.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimer's disease. AU - Lorenzl,Stefan, AU - Albers,David S, AU - Relkin,Norman, AU - Ngyuen,Terry, AU - Hilgenberg,Sarah L, AU - Chirichigno,Jason, AU - Cudkowicz,Merit E, AU - Beal,M Flint, PY - 2003/4/12/pubmed PY - 2003/7/17/medline PY - 2003/4/12/entrez SP - 191 EP - 6 JF - Neurochemistry international JO - Neurochem Int VL - 43 IS - 3 N2 - Matrix metalloproteinases (MMPs) may play a role in the pathophysiology of Alzheimer's disease (AD). MMP-9 and tissue inhibitors of metalloproteinases (TIMPs) are elevated in postmortem brain tissue of AD patients. MMPs and TIMPs are found in neurons, microglia, vascular endothelial cells and leukocytes. The aim of this study was to determine whether circulating levels of MMP-2, MMP-9, TIMP-1 and TIMP-2 are elevated in the plasma of AD patients. We compared AD patients to age- and gender-matched controls as well as to Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS) patients. There was constitutive expression of gelatinase A (MMP-2), and gelatinase B (MMP-9), in all the samples as shown by zymographic analysis. Levels of MMP-9 were significantly (P=0.003) elevated in the plasma of AD patients as compared to controls. Plasma levels of MMP-2, TIMP-1 and TIMP-2 were unchanged. There were no significant changes of MMP-2, MMP-9, TIMP-1 and TIMP-2 levels in PD and ALS samples. TIMP-1 and TIMP-2 were significantly correlated with MMP-9 in the AD patients. ApoE genotyping of plasma samples showed that levels of MMP-2, TIMP-1 and TIMP-2 and MMP-9 were not significantly different between the ApoE subgroups. These findings indicate that circulating levels of MMP-9 are increased in AD and may contribute to disease pathology. SN - 0197-0186 UR - https://www.unboundmedicine.com/medline/citation/12689599/Increased_plasma_levels_of_matrix_metalloproteinase_9_in_patients_with_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197018603000044 DB - PRIME DP - Unbound Medicine ER -