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Quantification of posterior capsule opacification with round and sharp edge intraocular lenses.
Ophthalmology. 2003 Apr; 110(4):772-80.O

Abstract

PURPOSE

To quantitatively evaluate and compare intraocular lenses (IOLs) with a round or sharp optic edge design for posterior capsule opacification (PCO).

STUDY DESIGN

Prospective comparative observational case series. PARTICIPANTS/MATERIALS: Photographs from 174 eyes were analyzed for PCO at the Department of Ophthalmology, Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.

MAIN OUTCOME MEASURES

Part I: 121 eyes of 121 patients were analyzed for quantification of PCO. IOLs evaluated were Corneal ACR6 (n = 21), Alcon Acrysof (n = 20), Allergan AR40 (n = 27), Pharmacia 811 one-piece polymethyl methacrylate (PMMA) IOL (n = 24), and Pharmacia 911A silicone IOL (n = 29). Mean follow-up was 14.01 +/- 2.81 months; mean patient age was 73.2 +/- 7.3 years. The morphologic PCO formation was evaluated for the entire optic and in the central 3-mm zone. Part II: In 53 eyes of 46 patients aged 73.4 +/- 10.8 years with an Alcon Acrysof IOL, PCO formation and capsulorrhexis/optic overlapping were analyzed 34.2 +/- 4 months after cataract surgery using EPCO Software.

RESULTS

Part I: The PCO values of the entire optic were for Corneal ACR6, 1.93 +/- 0.62; PMMA, 0.64 +/- 0.63; AR40, 0.55 +/- 0.28; Alcon Acrysof, 0.145 +/- 0.27; and 0.161 +/- 0.181 for the Pharmacia 911A IOL (P < 0.01). The PCO values of the central 3-mm zone were for Corneal ACR6, 1.64 +/- 0.96; PMMA, 0.49 +/- 0.39; AR40, 0.22 +/- 0.32; Alcon Acrysof, 0.08 +/- 0.21; and 0.06 +/- 0.11 for the Pharmacia 911A IOL (P < 0.01). Part II: Average overlapping of capsulorrhexis and Acrysof IOL optic was 40.5% +/- 12.4%. There was a significant correlation between PCO values and overlapping (r = -0.69, P < 0.001).

CONCLUSIONS

The sharp-edge IOL types (Alcon Acrysof and Pharmacia 911A silicone IOL) resulted in statistically significantly lower PCO values for analysis of the entire optic area and central 3-mm zone. There was no statistically significant difference in PCO values between the two sharp-edge optic IOLs. An overlapping of capsulorrhexis rim and the anterior IOL optic surface of more than 20% resulted in significantly lower PCO values with the Acrysof IOL.

Authors+Show Affiliations

Auffarth GU
Department of Ophthalmology, Ruprecht-Karls-University of Heidelberg, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany.
Golescu A
No affiliation info available
Becker KA
No affiliation info available
Völcker HE
No affiliation info available

MeSH

Acrylic ResinsAgedCapsulorhexisCataractHumansImage Processing, Computer-AssistedLens Capsule, CrystallineLens Implantation, IntraocularLenses, IntraocularPolymethyl MethacrylatePostoperative ComplicationsProspective StudiesProsthesis DesignSilicone Elastomers

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12689901

Citation

Auffarth, Gerd U., et al. "Quantification of Posterior Capsule Opacification With Round and Sharp Edge Intraocular Lenses." Ophthalmology, vol. 110, no. 4, 2003, pp. 772-80.
Auffarth GU, Golescu A, Becker KA, et al. Quantification of posterior capsule opacification with round and sharp edge intraocular lenses. Ophthalmology. 2003;110(4):772-80.
Auffarth, G. U., Golescu, A., Becker, K. A., & Völcker, H. E. (2003). Quantification of posterior capsule opacification with round and sharp edge intraocular lenses. Ophthalmology, 110(4), 772-80.
Auffarth GU, et al. Quantification of Posterior Capsule Opacification With Round and Sharp Edge Intraocular Lenses. Ophthalmology. 2003;110(4):772-80. PubMed PMID: 12689901.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantification of posterior capsule opacification with round and sharp edge intraocular lenses. AU - Auffarth,Gerd U, AU - Golescu,Ariadne, AU - Becker,Klio A, AU - Völcker,Hans E, PY - 2003/4/12/pubmed PY - 2003/5/8/medline PY - 2003/4/12/entrez SP - 772 EP - 80 JF - Ophthalmology JO - Ophthalmology VL - 110 IS - 4 N2 - PURPOSE: To quantitatively evaluate and compare intraocular lenses (IOLs) with a round or sharp optic edge design for posterior capsule opacification (PCO). STUDY DESIGN: Prospective comparative observational case series. PARTICIPANTS/MATERIALS: Photographs from 174 eyes were analyzed for PCO at the Department of Ophthalmology, Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany. MAIN OUTCOME MEASURES: Part I: 121 eyes of 121 patients were analyzed for quantification of PCO. IOLs evaluated were Corneal ACR6 (n = 21), Alcon Acrysof (n = 20), Allergan AR40 (n = 27), Pharmacia 811 one-piece polymethyl methacrylate (PMMA) IOL (n = 24), and Pharmacia 911A silicone IOL (n = 29). Mean follow-up was 14.01 +/- 2.81 months; mean patient age was 73.2 +/- 7.3 years. The morphologic PCO formation was evaluated for the entire optic and in the central 3-mm zone. Part II: In 53 eyes of 46 patients aged 73.4 +/- 10.8 years with an Alcon Acrysof IOL, PCO formation and capsulorrhexis/optic overlapping were analyzed 34.2 +/- 4 months after cataract surgery using EPCO Software. RESULTS: Part I: The PCO values of the entire optic were for Corneal ACR6, 1.93 +/- 0.62; PMMA, 0.64 +/- 0.63; AR40, 0.55 +/- 0.28; Alcon Acrysof, 0.145 +/- 0.27; and 0.161 +/- 0.181 for the Pharmacia 911A IOL (P < 0.01). The PCO values of the central 3-mm zone were for Corneal ACR6, 1.64 +/- 0.96; PMMA, 0.49 +/- 0.39; AR40, 0.22 +/- 0.32; Alcon Acrysof, 0.08 +/- 0.21; and 0.06 +/- 0.11 for the Pharmacia 911A IOL (P < 0.01). Part II: Average overlapping of capsulorrhexis and Acrysof IOL optic was 40.5% +/- 12.4%. There was a significant correlation between PCO values and overlapping (r = -0.69, P < 0.001). CONCLUSIONS: The sharp-edge IOL types (Alcon Acrysof and Pharmacia 911A silicone IOL) resulted in statistically significantly lower PCO values for analysis of the entire optic area and central 3-mm zone. There was no statistically significant difference in PCO values between the two sharp-edge optic IOLs. An overlapping of capsulorrhexis rim and the anterior IOL optic surface of more than 20% resulted in significantly lower PCO values with the Acrysof IOL. SN - 0161-6420 UR - https://www.unboundmedicine.com/medline/citation/12689901/Quantification_of_posterior_capsule_opacification_with_round_and_sharp_edge_intraocular_lenses_ DB - PRIME DP - Unbound Medicine ER -