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Assessment of cardiac autonomic modulation during adolescent obesity.
Obes Res 2003; 11(4):541-8OR

Abstract

OBJECTIVE

To investigate the cardiovascular autonomic function in pediatric obesity of different duration by using standard time domain, spectral heart rate variability (HRV), and nonlinear methods.

RESEARCH METHODS AND PROCEDURES

Fifty obese children (13.9 +/- 1.7 years) were compared with 12 lean subjects (12.9 +/- 1.6 years). Obese children were classified as recent obese (ROB) (<4 years), intermediate obese (IOB) (4 to 7 years), and long-term obese (OB) (>7 years). In all participants, we performed blood pressure (BP) measurements, laboratory tests, and 24-hour electrocardiogram/ambulatory BP monitoring. The spectral power was quantified in total power, very low-frequency (LF) power, high-frequency (HF) power, and LF to HF ratio. Total, long-term, and short-term time domain HRV were calculated. Poincaré plot and quadrant methods were used as nonlinear techniques.

RESULTS

All obese groups had higher casual and ambulatory BP and higher glucose, homeostasis model assessment, and triglyceride levels. All parameters reflecting parasympathetic tone (HF band, root mean square successive difference, proportion of successive normal-to-normal intervals, and scatterplot width) were significantly and persistently reduced in all obese groups in comparison with lean controls. LF normalized units, LF/HF, and cardiac acceleration (reflecting sympathetic activation) were significantly increased in the ROB group. In IOB and OB groups, LF, but not nonlinear, measures were similar to lean controls, suggesting biphasic behavior of sympathetic tone, whereas nonlinear analysis showed a decreasing trend with the duration of obesity. Long-term HRV measures were significantly reduced in ROB and IOB.

DISCUSSION

Autonomic nervous system changes in adolescent obesity seem to be related to its duration. Nonlinear methods of scatterplot and quadrant analysis permit assessment of autonomic balance, despite measuring different aspects of HRV.

Authors+Show Affiliations

Hypertension Unit, S. Vito Hospital, University of Turin, Italy. franco.rabbia@libero.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12690083

Citation

Rabbia, Franco, et al. "Assessment of Cardiac Autonomic Modulation During Adolescent Obesity." Obesity Research, vol. 11, no. 4, 2003, pp. 541-8.
Rabbia F, Silke B, Conterno A, et al. Assessment of cardiac autonomic modulation during adolescent obesity. Obes Res. 2003;11(4):541-8.
Rabbia, F., Silke, B., Conterno, A., Grosso, T., De Vito, B., Rabbone, I., ... Veglio, F. (2003). Assessment of cardiac autonomic modulation during adolescent obesity. Obesity Research, 11(4), pp. 541-8.
Rabbia F, et al. Assessment of Cardiac Autonomic Modulation During Adolescent Obesity. Obes Res. 2003;11(4):541-8. PubMed PMID: 12690083.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of cardiac autonomic modulation during adolescent obesity. AU - Rabbia,Franco, AU - Silke,Bernard, AU - Conterno,Andrea, AU - Grosso,Tiziana, AU - De Vito,Barbara, AU - Rabbone,Ivana, AU - Chiandussi,Livio, AU - Veglio,Franco, PY - 2003/4/12/pubmed PY - 2003/11/5/medline PY - 2003/4/12/entrez SP - 541 EP - 8 JF - Obesity research JO - Obes. Res. VL - 11 IS - 4 N2 - OBJECTIVE: To investigate the cardiovascular autonomic function in pediatric obesity of different duration by using standard time domain, spectral heart rate variability (HRV), and nonlinear methods. RESEARCH METHODS AND PROCEDURES: Fifty obese children (13.9 +/- 1.7 years) were compared with 12 lean subjects (12.9 +/- 1.6 years). Obese children were classified as recent obese (ROB) (<4 years), intermediate obese (IOB) (4 to 7 years), and long-term obese (OB) (>7 years). In all participants, we performed blood pressure (BP) measurements, laboratory tests, and 24-hour electrocardiogram/ambulatory BP monitoring. The spectral power was quantified in total power, very low-frequency (LF) power, high-frequency (HF) power, and LF to HF ratio. Total, long-term, and short-term time domain HRV were calculated. Poincaré plot and quadrant methods were used as nonlinear techniques. RESULTS: All obese groups had higher casual and ambulatory BP and higher glucose, homeostasis model assessment, and triglyceride levels. All parameters reflecting parasympathetic tone (HF band, root mean square successive difference, proportion of successive normal-to-normal intervals, and scatterplot width) were significantly and persistently reduced in all obese groups in comparison with lean controls. LF normalized units, LF/HF, and cardiac acceleration (reflecting sympathetic activation) were significantly increased in the ROB group. In IOB and OB groups, LF, but not nonlinear, measures were similar to lean controls, suggesting biphasic behavior of sympathetic tone, whereas nonlinear analysis showed a decreasing trend with the duration of obesity. Long-term HRV measures were significantly reduced in ROB and IOB. DISCUSSION: Autonomic nervous system changes in adolescent obesity seem to be related to its duration. Nonlinear methods of scatterplot and quadrant analysis permit assessment of autonomic balance, despite measuring different aspects of HRV. SN - 1071-7323 UR - https://www.unboundmedicine.com/medline/citation/12690083/Assessment_of_cardiac_autonomic_modulation_during_adolescent_obesity_ L2 - https://doi.org/10.1038/oby.2003.76 DB - PRIME DP - Unbound Medicine ER -