Tags

Type your tag names separated by a space and hit enter

Systematic reviews of treatment for chronic inflammatory demyelinating neuropathy.
Rev Neurol (Paris). 2002 Dec; 158(12 Pt 2):S32-6.RN

Abstract

Chronic inflammatory demyelinating polyradiculoneuropathies include chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), multifocal motor neuropathy (MMN) and paraprotein-associated demyelinating neuropathy. This review summarises the evidence from randomised controlled trials (RCTs) for the treatment of these conditions. It leads to the conclusions that: 1) steroids are beneficial in CIDP but not MMN and their efficacy in paraproteinaemic demyelinating neuropathy (PDN) is uncertain; 2) intravenous immunoglobulin (IVIg) produces short-term benefit in CIDP, MMN and IgM PDN. Its effect in IgG or IgA PDN has not been tested in RCTs; 3) plasma exchange (PE) also produces short-term benefit in CIDP and IgG or IgA PDN but probably not in MMN; 4) there is almost no information from RCTs concerning the possible benefits of immunosuppressive agents; and 5) volunteers are needed to write Cochrane systematic reviews of IVIg for MMN and of interventions for PDN associated with IgG and IgA.

Authors+Show Affiliations

Guy's, King's and St Thomas' School of Medicine, Guy's Hospital, London SE1 1UL, UK.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

12690659

Citation

Hughes, R A C.. "Systematic Reviews of Treatment for Chronic Inflammatory Demyelinating Neuropathy." Revue Neurologique, vol. 158, no. 12 Pt 2, 2002, pp. S32-6.
Hughes RA. Systematic reviews of treatment for chronic inflammatory demyelinating neuropathy. Rev Neurol (Paris). 2002;158(12 Pt 2):S32-6.
Hughes, R. A. (2002). Systematic reviews of treatment for chronic inflammatory demyelinating neuropathy. Revue Neurologique, 158(12 Pt 2), S32-6.
Hughes RA. Systematic Reviews of Treatment for Chronic Inflammatory Demyelinating Neuropathy. Rev Neurol (Paris). 2002;158(12 Pt 2):S32-6. PubMed PMID: 12690659.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Systematic reviews of treatment for chronic inflammatory demyelinating neuropathy. A1 - Hughes,R A C, PY - 2003/4/15/pubmed PY - 2003/5/2/medline PY - 2003/4/15/entrez SP - S32 EP - 6 JF - Revue neurologique JO - Rev. Neurol. (Paris) VL - 158 IS - 12 Pt 2 N2 - Chronic inflammatory demyelinating polyradiculoneuropathies include chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), multifocal motor neuropathy (MMN) and paraprotein-associated demyelinating neuropathy. This review summarises the evidence from randomised controlled trials (RCTs) for the treatment of these conditions. It leads to the conclusions that: 1) steroids are beneficial in CIDP but not MMN and their efficacy in paraproteinaemic demyelinating neuropathy (PDN) is uncertain; 2) intravenous immunoglobulin (IVIg) produces short-term benefit in CIDP, MMN and IgM PDN. Its effect in IgG or IgA PDN has not been tested in RCTs; 3) plasma exchange (PE) also produces short-term benefit in CIDP and IgG or IgA PDN but probably not in MMN; 4) there is almost no information from RCTs concerning the possible benefits of immunosuppressive agents; and 5) volunteers are needed to write Cochrane systematic reviews of IVIg for MMN and of interventions for PDN associated with IgG and IgA. SN - 0035-3787 UR - https://www.unboundmedicine.com/medline/citation/12690659/Systematic_reviews_of_treatment_for_chronic_inflammatory_demyelinating_neuropathy_ DB - PRIME DP - Unbound Medicine ER -