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Relatedness and heterogeneity at the near-terminal end of the genome of a parapoxvirus bovis 1 strain (B177) compared with parapoxvirus ovis (Orf virus).
J Gen Virol 2003; 84(Pt 5):1111-6JG

Abstract

The present study provides for the first time an extended investigation of individual genes located at the near-terminal right end of the genome of parapoxvirus bovis 1, Bovine papular stomatitis virus (BPSV) strain B177 and Orf virus (ORFV). Comparison of the respective DNA sequences of ORFV strain D1701 (9.9 kbp) and BPSV B177 (7.7 kbp) revealed a very similar organization of closely related genes transcribed in a rightward orientation. The most salient findings of this study were: (i) the absence of the ORFV-specific vascular endothelial growth factor (VEGF-E) gene in the BPSV isolate; (ii) the presence of an interleukin-10 (IL-10) orthologue; and (iii) the detection of three new genes encoding ankyrin-repeat-containing polypeptides. These results not only contribute to potential improvements of future molecular differentiation between the parapoxvirus species, but also shed new light on different pathobiologies among parapoxviruses.

Authors+Show Affiliations

Federal Research Centre for Virus Diseases of Animals, Institute of Immunology, Paul-Ehrlich-Strasse 28, D-72076 Tübingen, Federal Republic of Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12692275

Citation

Rziha, H-J, et al. "Relatedness and Heterogeneity at the Near-terminal End of the Genome of a Parapoxvirus Bovis 1 Strain (B177) Compared With Parapoxvirus Ovis (Orf Virus)." The Journal of General Virology, vol. 84, no. Pt 5, 2003, pp. 1111-6.
Rziha HJ, Bauer B, Adam KH, et al. Relatedness and heterogeneity at the near-terminal end of the genome of a parapoxvirus bovis 1 strain (B177) compared with parapoxvirus ovis (Orf virus). J Gen Virol. 2003;84(Pt 5):1111-6.
Rziha, H. J., Bauer, B., Adam, K. H., Röttgen, M., Cottone, R., Henkel, M., ... Büttner, M. (2003). Relatedness and heterogeneity at the near-terminal end of the genome of a parapoxvirus bovis 1 strain (B177) compared with parapoxvirus ovis (Orf virus). The Journal of General Virology, 84(Pt 5), pp. 1111-6.
Rziha HJ, et al. Relatedness and Heterogeneity at the Near-terminal End of the Genome of a Parapoxvirus Bovis 1 Strain (B177) Compared With Parapoxvirus Ovis (Orf Virus). J Gen Virol. 2003;84(Pt 5):1111-6. PubMed PMID: 12692275.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relatedness and heterogeneity at the near-terminal end of the genome of a parapoxvirus bovis 1 strain (B177) compared with parapoxvirus ovis (Orf virus). AU - Rziha,H-J, AU - Bauer,B, AU - Adam,K-H, AU - Röttgen,M, AU - Cottone,R, AU - Henkel,M, AU - Dehio,C, AU - Büttner,M, PY - 2003/4/15/pubmed PY - 2003/6/5/medline PY - 2003/4/15/entrez SP - 1111 EP - 6 JF - The Journal of general virology JO - J. Gen. Virol. VL - 84 IS - Pt 5 N2 - The present study provides for the first time an extended investigation of individual genes located at the near-terminal right end of the genome of parapoxvirus bovis 1, Bovine papular stomatitis virus (BPSV) strain B177 and Orf virus (ORFV). Comparison of the respective DNA sequences of ORFV strain D1701 (9.9 kbp) and BPSV B177 (7.7 kbp) revealed a very similar organization of closely related genes transcribed in a rightward orientation. The most salient findings of this study were: (i) the absence of the ORFV-specific vascular endothelial growth factor (VEGF-E) gene in the BPSV isolate; (ii) the presence of an interleukin-10 (IL-10) orthologue; and (iii) the detection of three new genes encoding ankyrin-repeat-containing polypeptides. These results not only contribute to potential improvements of future molecular differentiation between the parapoxvirus species, but also shed new light on different pathobiologies among parapoxviruses. SN - 0022-1317 UR - https://www.unboundmedicine.com/medline/citation/12692275/Relatedness_and_heterogeneity_at_the_near_terminal_end_of_the_genome_of_a_parapoxvirus_bovis_1_strain__B177__compared_with_parapoxvirus_ovis__Orf_virus__ L2 - http://jgv.microbiologyresearch.org/pubmed/content/journal/jgv/10.1099/vir.0.18850-0 DB - PRIME DP - Unbound Medicine ER -