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Severe palmo-plantar hyperkeratosis in Koebner epidermolysis bullosa simplex.
J Dermatol. 2003 Feb; 30(2):135-40.JD

Abstract

A 22-year-old Japanese woman with Koebner epidermolysis bullosa simplex presented with severe palmo-plantar hyperkeratosis. Skin biopsy specimens from the palm revealed hyperkeratosis and acanthosis with blistering in the basal cell layer. An electron microscopic study showed cytolysis of basal cells and clumping of tonofilaments forming thick bundles and perinuclear electron-dense bodies. Hand contractures were released and covered with full thickness autografts or split thickness autografts. The donor site was successfully treated with cultured epidermal autografts.

Authors+Show Affiliations

Department of Dermatology, Ehime University School of Medicine, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

12692381

Citation

Shirakata, Yuji, et al. "Severe Palmo-plantar Hyperkeratosis in Koebner Epidermolysis Bullosa Simplex." The Journal of Dermatology, vol. 30, no. 2, 2003, pp. 135-40.
Shirakata Y, Tamai K, Nakaoka H, et al. Severe palmo-plantar hyperkeratosis in Koebner epidermolysis bullosa simplex. J Dermatol. 2003;30(2):135-40.
Shirakata, Y., Tamai, K., Nakaoka, H., Tokumaru, S., Sayama, K., Murakami, S., & Hashimoto, K. (2003). Severe palmo-plantar hyperkeratosis in Koebner epidermolysis bullosa simplex. The Journal of Dermatology, 30(2), 135-40.
Shirakata Y, et al. Severe Palmo-plantar Hyperkeratosis in Koebner Epidermolysis Bullosa Simplex. J Dermatol. 2003;30(2):135-40. PubMed PMID: 12692381.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severe palmo-plantar hyperkeratosis in Koebner epidermolysis bullosa simplex. AU - Shirakata,Yuji, AU - Tamai,Katsuto, AU - Nakaoka,Hiroki, AU - Tokumaru,Sho, AU - Sayama,Koji, AU - Murakami,Shinji, AU - Hashimoto,Koji, PY - 2002/08/28/received PY - 2002/11/21/accepted PY - 2003/4/15/pubmed PY - 2003/5/2/medline PY - 2003/4/15/entrez SP - 135 EP - 40 JF - The Journal of dermatology JO - J Dermatol VL - 30 IS - 2 N2 - A 22-year-old Japanese woman with Koebner epidermolysis bullosa simplex presented with severe palmo-plantar hyperkeratosis. Skin biopsy specimens from the palm revealed hyperkeratosis and acanthosis with blistering in the basal cell layer. An electron microscopic study showed cytolysis of basal cells and clumping of tonofilaments forming thick bundles and perinuclear electron-dense bodies. Hand contractures were released and covered with full thickness autografts or split thickness autografts. The donor site was successfully treated with cultured epidermal autografts. SN - 0385-2407 UR - https://www.unboundmedicine.com/medline/citation/12692381/Severe_palmo_plantar_hyperkeratosis_in_Koebner_epidermolysis_bullosa_simplex_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0385-2407&date=2003&volume=30&issue=2&spage=135 DB - PRIME DP - Unbound Medicine ER -