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Efficacy and tolerability of finasteride 1 mg in men aged 41 to 60 years with male pattern hair loss.
Eur J Dermatol. 2003 Mar-Apr; 13(2):150-60.EJ

Abstract

A 24-month double-blind, randomized, placebo-controlled, parallel-group, multicenter study of 424 men was conducted to determine the efficacy and tolerability of finasteride 1 mg on hair growth/loss in men aged 41 to 60 years with mild-to-moderate, predominantly vertex male pattern hair loss. Efficacy was evaluated by review of global photographs of the vertex scalp taken at baseline and at Months 6, 12, 18, and 24 and by patient self-assessments and investigator clinical assessments of change from baseline in hair growth/loss collected at Months 6, 12, 18, and 24. Safety analyses included assessment of clinical and laboratory adverse experiences, including sexual adverse experiences. Analysis of global photographic assessment data showed significant improvement in hair growth for men in the finasteride group compared with those taking placebo beginning at Month 6 (p < 0.001) and maintained through Month 24 (p < 0.001). Results of the patient self-assessment and investigator assessments were consistent with those from the global photographic assessment. Finasteride 1 mg improved scalp hair growth in men aged 41 to 60 years with predominantly vertex male pattern hair loss compared with results seen with placebo. Improvement was evident by 6 months of treatment and continued through 24 months. Treatment with finasteride 1 mg was generally well tolerated.

Authors+Show Affiliations

Whiting DA
Dallas Associated Dermatologists, 3600 Gaston Avenue, #1051 LB76, TX 75246, USA.
Olsen EA
No affiliation info available
Savin R
No affiliation info available
Halper L
No affiliation info available
Rodgers A
No affiliation info available
Wang L
No affiliation info available
Hustad C
No affiliation info available
Palmisano J
No affiliation info available
Male Pattern Hair Loss Study Group
No affiliation info available

MeSH

AdultAlopeciaDihydrotestosteroneDouble-Blind MethodEnzyme InhibitorsFinasterideHumansMaleMiddle AgedTestosteroneTreatment Outcome

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

12695131

Citation

Whiting, David A., et al. "Efficacy and Tolerability of Finasteride 1 Mg in Men Aged 41 to 60 Years With Male Pattern Hair Loss." European Journal of Dermatology : EJD, vol. 13, no. 2, 2003, pp. 150-60.
Whiting DA, Olsen EA, Savin R, et al. Efficacy and tolerability of finasteride 1 mg in men aged 41 to 60 years with male pattern hair loss. Eur J Dermatol. 2003;13(2):150-60.
Whiting, D. A., Olsen, E. A., Savin, R., Halper, L., Rodgers, A., Wang, L., Hustad, C., & Palmisano, J. (2003). Efficacy and tolerability of finasteride 1 mg in men aged 41 to 60 years with male pattern hair loss. European Journal of Dermatology : EJD, 13(2), 150-60.
Whiting DA, et al. Efficacy and Tolerability of Finasteride 1 Mg in Men Aged 41 to 60 Years With Male Pattern Hair Loss. Eur J Dermatol. 2003 Mar-Apr;13(2):150-60. PubMed PMID: 12695131.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy and tolerability of finasteride 1 mg in men aged 41 to 60 years with male pattern hair loss. AU - Whiting,David A, AU - Olsen,Elise A, AU - Savin,Ronald, AU - Halper,Lee, AU - Rodgers,Anthony, AU - Wang,Lixia, AU - Hustad,Carolynn, AU - Palmisano,Joanne, AU - ,, PY - 2003/4/16/pubmed PY - 2003/8/2/medline PY - 2003/4/16/entrez SP - 150 EP - 60 JF - European journal of dermatology : EJD JO - Eur J Dermatol VL - 13 IS - 2 N2 - A 24-month double-blind, randomized, placebo-controlled, parallel-group, multicenter study of 424 men was conducted to determine the efficacy and tolerability of finasteride 1 mg on hair growth/loss in men aged 41 to 60 years with mild-to-moderate, predominantly vertex male pattern hair loss. Efficacy was evaluated by review of global photographs of the vertex scalp taken at baseline and at Months 6, 12, 18, and 24 and by patient self-assessments and investigator clinical assessments of change from baseline in hair growth/loss collected at Months 6, 12, 18, and 24. Safety analyses included assessment of clinical and laboratory adverse experiences, including sexual adverse experiences. Analysis of global photographic assessment data showed significant improvement in hair growth for men in the finasteride group compared with those taking placebo beginning at Month 6 (p < 0.001) and maintained through Month 24 (p < 0.001). Results of the patient self-assessment and investigator assessments were consistent with those from the global photographic assessment. Finasteride 1 mg improved scalp hair growth in men aged 41 to 60 years with predominantly vertex male pattern hair loss compared with results seen with placebo. Improvement was evident by 6 months of treatment and continued through 24 months. Treatment with finasteride 1 mg was generally well tolerated. SN - 1167-1122 UR - https://www.unboundmedicine.com/medline/citation/12695131/Efficacy_and_tolerability_of_finasteride_1_mg_in_men_aged_41_to_60_years_with_male_pattern_hair_loss_ DB - PRIME DP - Unbound Medicine ER -