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Nitrendipine-induced subacute cutaneous lupus erythematosus.
Eur J Dermatol. 2003 Mar-Apr; 13(2):213-6.EJ

Abstract

A 66-year-old man presented with widespread annular and bullous subacute cutaneous lupus erythematosus (SCLE), developed after starting treatment for hypertension with the calcium channel blocker nitrendipine. A few days after withdrawal of the drug, while cutaneous manifestations were improving, left hemiparesis occurred. Laboratory investigations showed, in addition to anti-Ro, anti-La and anti-histone antibodies, the presence of lupus anticoagulant, anticardiolipin antibodies, prolonged APTT and thrombocytopenia. On the basis of the spontaneous regression of the patient's skin lesions after discontinuation of the drug, a possible relationship between nitrendipine intake, the clinical events and the biological findings is discussed.

Authors+Show Affiliations

Marzano AV
Institute of Dermatological Sciences of the University of Milan, Via Pace, Italy. mizzidoc@libero.it
Borghi A
No affiliation info available
Mercogliano M
No affiliation info available
Facchetti M
No affiliation info available
Caputo R
No affiliation info available

MeSH

AgedAutoantibodiesCalcium Channel BlockersHumansLupus Erythematosus, CutaneousMaleNitrendipineParesis

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

12695145

Citation

Marzano, Angelo V., et al. "Nitrendipine-induced Subacute Cutaneous Lupus Erythematosus." European Journal of Dermatology : EJD, vol. 13, no. 2, 2003, pp. 213-6.
Marzano AV, Borghi A, Mercogliano M, et al. Nitrendipine-induced subacute cutaneous lupus erythematosus. Eur J Dermatol. 2003;13(2):213-6.
Marzano, A. V., Borghi, A., Mercogliano, M., Facchetti, M., & Caputo, R. (2003). Nitrendipine-induced subacute cutaneous lupus erythematosus. European Journal of Dermatology : EJD, 13(2), 213-6.
Marzano AV, et al. Nitrendipine-induced Subacute Cutaneous Lupus Erythematosus. Eur J Dermatol. 2003 Mar-Apr;13(2):213-6. PubMed PMID: 12695145.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nitrendipine-induced subacute cutaneous lupus erythematosus. AU - Marzano,Angelo V, AU - Borghi,Alessandro, AU - Mercogliano,Maurizio, AU - Facchetti,Maura, AU - Caputo,Ruggero, PY - 2003/4/16/pubmed PY - 2003/8/2/medline PY - 2003/4/16/entrez SP - 213 EP - 6 JF - European journal of dermatology : EJD JO - Eur J Dermatol VL - 13 IS - 2 N2 - A 66-year-old man presented with widespread annular and bullous subacute cutaneous lupus erythematosus (SCLE), developed after starting treatment for hypertension with the calcium channel blocker nitrendipine. A few days after withdrawal of the drug, while cutaneous manifestations were improving, left hemiparesis occurred. Laboratory investigations showed, in addition to anti-Ro, anti-La and anti-histone antibodies, the presence of lupus anticoagulant, anticardiolipin antibodies, prolonged APTT and thrombocytopenia. On the basis of the spontaneous regression of the patient's skin lesions after discontinuation of the drug, a possible relationship between nitrendipine intake, the clinical events and the biological findings is discussed. SN - 1167-1122 UR - https://www.unboundmedicine.com/medline/citation/12695145/Nitrendipine_induced_subacute_cutaneous_lupus_erythematosus_ DB - PRIME DP - Unbound Medicine ER -