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The effect of latanoprost, brimonidine, and a fixed combination of timolol and dorzolamide on circadian intraocular pressure in patients with glaucoma or ocular hypertension.
Arch Ophthalmol. 2003 Apr; 121(4):453-7.AO

Abstract

OBJECTIVE

To compare the circadian intraocular pressure (IOP) reductions induced by latanoprost, brimonidine tartrate, and a fixed combination of timolol maleate and dorzolamide hydrochloride in patients with primary open-angle glaucoma (POAG) or ocular hypertension (OHT).

METHODS

In this crossover study, 10 patients with POAG and 10 with OHT were treated with latanoprost once a day, brimonidine twice a day, and a fixed combination of timolol and dorzolamide twice a day for 1 month. Four 24-hour tonometric curves were obtained for each patient. Intraocular pressure (IOP) was measured at 3, 6, and 9 AM, and at noon and at 3, 6, and 9 PM, and at midnight, using a handheld electronic tonometer with the patient in supine and sitting positions and a Goldmann applanation tonometer with the patient sitting at the slitlamp.

MAIN OUTCOME MEASURE

Reduction of circadian IOP.

RESULTS

All the drugs significantly reduced IOP compared with the baseline at all times, except for brimonidine at midnight, 3 AM, and 6 AM. Latanoprost was more effective than brimonidine in lowering IOP at 3 and 6 AM and at 3 PM (P=.03), and the combination of timolol and dorzolamide was more effective than brimonidine at 3 and 9 AM (P=.04) and at 3 and 6 PM (P =.05) and more effective than latanoprost at 9 AM (P=.05).

CONCLUSION

Latanoprost and the fixed combination of timolol and dorzolamide led to similar circadian reductions in IOP, whereas brimonidine was less effective, particularly during the night.

Authors+Show Affiliations

Eye Clinic, Institute of Biomedical Sciences, University of Milan, San Paolo Hospital, Milan, Italy. lucamrosetti@libero.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

12695241

Citation

Orzalesi, Nicola, et al. "The Effect of Latanoprost, Brimonidine, and a Fixed Combination of Timolol and Dorzolamide On Circadian Intraocular Pressure in Patients With Glaucoma or Ocular Hypertension." Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 121, no. 4, 2003, pp. 453-7.
Orzalesi N, Rossetti L, Bottoli A, et al. The effect of latanoprost, brimonidine, and a fixed combination of timolol and dorzolamide on circadian intraocular pressure in patients with glaucoma or ocular hypertension. Arch Ophthalmol. 2003;121(4):453-7.
Orzalesi, N., Rossetti, L., Bottoli, A., Fumagalli, E., & Fogagnolo, P. (2003). The effect of latanoprost, brimonidine, and a fixed combination of timolol and dorzolamide on circadian intraocular pressure in patients with glaucoma or ocular hypertension. Archives of Ophthalmology (Chicago, Ill. : 1960), 121(4), 453-7.
Orzalesi N, et al. The Effect of Latanoprost, Brimonidine, and a Fixed Combination of Timolol and Dorzolamide On Circadian Intraocular Pressure in Patients With Glaucoma or Ocular Hypertension. Arch Ophthalmol. 2003;121(4):453-7. PubMed PMID: 12695241.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of latanoprost, brimonidine, and a fixed combination of timolol and dorzolamide on circadian intraocular pressure in patients with glaucoma or ocular hypertension. AU - Orzalesi,Nicola, AU - Rossetti,Luca, AU - Bottoli,Andrea, AU - Fumagalli,Elena, AU - Fogagnolo,Paolo, PY - 2003/4/16/pubmed PY - 2003/4/29/medline PY - 2003/4/16/entrez SP - 453 EP - 7 JF - Archives of ophthalmology (Chicago, Ill. : 1960) JO - Arch. Ophthalmol. VL - 121 IS - 4 N2 - OBJECTIVE: To compare the circadian intraocular pressure (IOP) reductions induced by latanoprost, brimonidine tartrate, and a fixed combination of timolol maleate and dorzolamide hydrochloride in patients with primary open-angle glaucoma (POAG) or ocular hypertension (OHT). METHODS: In this crossover study, 10 patients with POAG and 10 with OHT were treated with latanoprost once a day, brimonidine twice a day, and a fixed combination of timolol and dorzolamide twice a day for 1 month. Four 24-hour tonometric curves were obtained for each patient. Intraocular pressure (IOP) was measured at 3, 6, and 9 AM, and at noon and at 3, 6, and 9 PM, and at midnight, using a handheld electronic tonometer with the patient in supine and sitting positions and a Goldmann applanation tonometer with the patient sitting at the slitlamp. MAIN OUTCOME MEASURE: Reduction of circadian IOP. RESULTS: All the drugs significantly reduced IOP compared with the baseline at all times, except for brimonidine at midnight, 3 AM, and 6 AM. Latanoprost was more effective than brimonidine in lowering IOP at 3 and 6 AM and at 3 PM (P=.03), and the combination of timolol and dorzolamide was more effective than brimonidine at 3 and 9 AM (P=.04) and at 3 and 6 PM (P =.05) and more effective than latanoprost at 9 AM (P=.05). CONCLUSION: Latanoprost and the fixed combination of timolol and dorzolamide led to similar circadian reductions in IOP, whereas brimonidine was less effective, particularly during the night. SN - 0003-9950 UR - https://www.unboundmedicine.com/medline/citation/12695241/The_effect_of_latanoprost_brimonidine_and_a_fixed_combination_of_timolol_and_dorzolamide_on_circadian_intraocular_pressure_in_patients_with_glaucoma_or_ocular_hypertension_ L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/vol/121/pg/453 DB - PRIME DP - Unbound Medicine ER -