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[Molecular epidemiology of rabies epizootics in Colombia, 1994-2002: evidence of human and canine rabies associated with chiroptera].
Biomedica. 2003 Mar; 23(1):19-30.B

Abstract

Three urban rabies outbreaks have been reported in Colombia during the last two decades, one of which is ongoing in the Caribbean region (northern Colombia). The earlier outbreaks occurred almost simultaneously in Arauca (eastern Colombia) and in the Central region, ending in 1997. Phylogenetic relationships among rabies viruses isolated from the three areas were based on a comparison of cDNA fragments coding for the endodomain of protein G and a fragment of L protein obtained by RT-PCR. The sequenced amplicons which included the G-L intergenic region contained 902 base pairs. Phylogenetic analysis showed three distinct groups of viruses. Colombian genetic variant I viruses were isolated only from Arauca and the Central region, but are now apparently extinct. Colombian genetic variant II viruses were isolated in the Caribbean region and are still being transmitted in that area. The third group of bat rabies variants were isolated from two insectivorous bats, three domestic dogs and a human. This associates bat rabies virus with rabies in Colombian dogs and humans, and indicates bats to be a rabies reservoir of public health significance.

Authors+Show Affiliations

Laboratorio de Virología, Instituto Nacional de Salud, Departamento de Ciencias Básicas, Universidad de La Salle, Bogotá, D.C., Colombia. apaezm@hemagogus.ins.gov.coNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

spa

PubMed ID

12696396

Citation

Páez, Andrés, et al. "[Molecular Epidemiology of Rabies Epizootics in Colombia, 1994-2002: Evidence of Human and Canine Rabies Associated With Chiroptera]." Biomedica : Revista Del Instituto Nacional De Salud, vol. 23, no. 1, 2003, pp. 19-30.
Páez A, Nuñez C, García C, et al. [Molecular epidemiology of rabies epizootics in Colombia, 1994-2002: evidence of human and canine rabies associated with chiroptera]. Biomedica. 2003;23(1):19-30.
Páez, A., Nuñez, C., García, C., & Boshell, J. (2003). [Molecular epidemiology of rabies epizootics in Colombia, 1994-2002: evidence of human and canine rabies associated with chiroptera]. Biomedica : Revista Del Instituto Nacional De Salud, 23(1), 19-30.
Páez A, et al. [Molecular Epidemiology of Rabies Epizootics in Colombia, 1994-2002: Evidence of Human and Canine Rabies Associated With Chiroptera]. Biomedica. 2003;23(1):19-30. PubMed PMID: 12696396.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Molecular epidemiology of rabies epizootics in Colombia, 1994-2002: evidence of human and canine rabies associated with chiroptera]. AU - Páez,Andrés, AU - Nuñez,Constanza, AU - García,Clemencia, AU - Boshell,Jorge, PY - 2003/4/17/pubmed PY - 2003/12/3/medline PY - 2003/4/17/entrez SP - 19 EP - 30 JF - Biomedica : revista del Instituto Nacional de Salud JO - Biomedica VL - 23 IS - 1 N2 - Three urban rabies outbreaks have been reported in Colombia during the last two decades, one of which is ongoing in the Caribbean region (northern Colombia). The earlier outbreaks occurred almost simultaneously in Arauca (eastern Colombia) and in the Central region, ending in 1997. Phylogenetic relationships among rabies viruses isolated from the three areas were based on a comparison of cDNA fragments coding for the endodomain of protein G and a fragment of L protein obtained by RT-PCR. The sequenced amplicons which included the G-L intergenic region contained 902 base pairs. Phylogenetic analysis showed three distinct groups of viruses. Colombian genetic variant I viruses were isolated only from Arauca and the Central region, but are now apparently extinct. Colombian genetic variant II viruses were isolated in the Caribbean region and are still being transmitted in that area. The third group of bat rabies variants were isolated from two insectivorous bats, three domestic dogs and a human. This associates bat rabies virus with rabies in Colombian dogs and humans, and indicates bats to be a rabies reservoir of public health significance. SN - 0120-4157 UR - https://www.unboundmedicine.com/medline/citation/12696396/[Molecular_epidemiology_of_rabies_epizootics_in_Colombia_1994_2002:_evidence_of_human_and_canine_rabies_associated_with_chiroptera]_ L2 - http://www.diseaseinfosearch.org/result/6131 DB - PRIME DP - Unbound Medicine ER -