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Plasma homocysteine concentration is decreased by dietary intervention.
Br J Nutr 2003; 89(3):295-301BJ

Abstract

High plasma total homocysteine (tHcy) concentration is reported to be a risk factor for vascular diseases. We investigated the extent to which serum folate and plasma tHcy respond to a high intake of natural folate from food. Thirty-seven healthy females volunteered t o participate in a crossover dietary intervention. The study included a baseline period and two 5-week diet periods (low- and high-folate diets) with a 3-week washout in between. The low-folate diet contained one serving of both vegetables and fruit/d, while during the high-folate diet the subjects ate at least seven servings of vegetables, berries, and citrus fruit/d. Serum and erythrocyte (RBC) folate, serum vitamin B (12), and plasma tHcy concentrations were measured at the base-line and at the end of each diet period. The mean concentrations of serum and RBC folate were 11.0 (SD 3.0) nmol/l and 412 (SD 120) nmol/l at the end of the low-folate diet and 78 (95 % CI 62, 94) % and 14 (95 % CI 8, 20) % higher in response to the high-folate diet (P< 0.001). The serum concentration of vitamin B12 remained unchanged during the intervention. The mean plasma tHcy concentration was 8.0 pmol/ at the end of the low-folate diet and decreased by 13 (95% CI 9, 18) % in response to the high-folate diet (P<0.001). In conclusion, a diet high in fresh berries, citrus fruit, and vegetables effectively increases serum and RBC folate and decreases plasma homocysteine.

Authors+Show Affiliations

Department of Internal Medicine, University of Oulu, Oulu, Finland. Maja-Leena.Silaste@oulu.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12696562

Citation

Silaste, Marja-Leena, et al. "Plasma Homocysteine Concentration Is Decreased By Dietary Intervention." The British Journal of Nutrition, vol. 89, no. 3, 2003, pp. 295-301.
Silaste ML, Rantala M, Alfthan G, et al. Plasma homocysteine concentration is decreased by dietary intervention. Br J Nutr. 2003;89(3):295-301.
Silaste, M. L., Rantala, M., Alfthan, G., Aro, A., & Kesäniemi, Y. A. (2003). Plasma homocysteine concentration is decreased by dietary intervention. The British Journal of Nutrition, 89(3), pp. 295-301.
Silaste ML, et al. Plasma Homocysteine Concentration Is Decreased By Dietary Intervention. Br J Nutr. 2003;89(3):295-301. PubMed PMID: 12696562.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma homocysteine concentration is decreased by dietary intervention. AU - Silaste,Marja-Leena, AU - Rantala,Maire, AU - Alfthan,Georg, AU - Aro,Antti, AU - Kesäniemi,Y Antero, PY - 2003/4/17/pubmed PY - 2003/5/16/medline PY - 2003/4/17/entrez SP - 295 EP - 301 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 89 IS - 3 N2 - High plasma total homocysteine (tHcy) concentration is reported to be a risk factor for vascular diseases. We investigated the extent to which serum folate and plasma tHcy respond to a high intake of natural folate from food. Thirty-seven healthy females volunteered t o participate in a crossover dietary intervention. The study included a baseline period and two 5-week diet periods (low- and high-folate diets) with a 3-week washout in between. The low-folate diet contained one serving of both vegetables and fruit/d, while during the high-folate diet the subjects ate at least seven servings of vegetables, berries, and citrus fruit/d. Serum and erythrocyte (RBC) folate, serum vitamin B (12), and plasma tHcy concentrations were measured at the base-line and at the end of each diet period. The mean concentrations of serum and RBC folate were 11.0 (SD 3.0) nmol/l and 412 (SD 120) nmol/l at the end of the low-folate diet and 78 (95 % CI 62, 94) % and 14 (95 % CI 8, 20) % higher in response to the high-folate diet (P< 0.001). The serum concentration of vitamin B12 remained unchanged during the intervention. The mean plasma tHcy concentration was 8.0 pmol/ at the end of the low-folate diet and decreased by 13 (95% CI 9, 18) % in response to the high-folate diet (P<0.001). In conclusion, a diet high in fresh berries, citrus fruit, and vegetables effectively increases serum and RBC folate and decreases plasma homocysteine. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/12696562/Plasma_homocysteine_concentration_is_decreased_by_dietary_intervention_ L2 - https://www.cambridge.org/core/product/identifier/S0007114503000369/type/journal_article DB - PRIME DP - Unbound Medicine ER -