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Conventional influenza vaccination is not associated with complications in working-age patients with asthma or chronic obstructive pulmonary disease.

Abstract

By using a nested case-control design, the authors studied the effectiveness of the influenza vaccine in reducing severe and fatal complications in 4,241 and 5,966 primary care, working-age patients aged 18-64 years who had asthma or chronic obstructive pulmonary disease during the 1998-1999 and 1999-2000 influenza epidemics in the Netherlands. Patients developing fatal or nonfatal exacerbations of lung disease, pneumonia, congestive heart failure, or myocardial infarction during either epidemic were considered cases. For each case, four age- and sex-matched controls were randomly sampled, and patient records were reviewed. Conditional logistic regression and propensity scores were used to assess vaccine effectiveness after adjustment for confounding factors. In seasons one and two, respectively, 87% (47/54) and 85% (171/202) of the cases and 74% (155/210) and 75% (575/766) of the controls had been vaccinated. After adjustments, vaccination was not associated with reductions in complications (season one: odds ratio = 0.95, 95% confidence interval (CI): 0.26, 3.48; season two: odds ratio = 1.07, 95% CI: 0.59, 1.96; pooled odds ratio = 1.07, 95% CI: 0.63, 1.80). Because influenza vaccination appeared not to be associated with a clinically relevant reduction in severe morbidity, other measures need to be explored.

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  • Authors+Show Affiliations

    ,

    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. E.Hak@med.uu.nl

    , , , , ,

    Source

    American journal of epidemiology 157:8 2003 Apr 15 pg 692-700

    MeSH

    Adolescent
    Adult
    Asthma
    Case-Control Studies
    Female
    Heart Failure
    Humans
    Influenza Vaccines
    Influenza, Human
    Lung Diseases
    Male
    Mass Vaccination
    Middle Aged
    Morbidity
    Myocardial Infarction
    Netherlands
    Pneumonia
    Prospective Studies
    Pulmonary Disease, Chronic Obstructive

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    12697573

    Citation

    Hak, E, et al. "Conventional Influenza Vaccination Is Not Associated With Complications in Working-age Patients With Asthma or Chronic Obstructive Pulmonary Disease." American Journal of Epidemiology, vol. 157, no. 8, 2003, pp. 692-700.
    Hak E, Hoes AW, Grobbee DE, et al. Conventional influenza vaccination is not associated with complications in working-age patients with asthma or chronic obstructive pulmonary disease. Am J Epidemiol. 2003;157(8):692-700.
    Hak, E., Hoes, A. W., Grobbee, D. E., Lammers, J. W., van Essen, G. A., van Loon, A. M., & Verheij, T. J. (2003). Conventional influenza vaccination is not associated with complications in working-age patients with asthma or chronic obstructive pulmonary disease. American Journal of Epidemiology, 157(8), pp. 692-700.
    Hak E, et al. Conventional Influenza Vaccination Is Not Associated With Complications in Working-age Patients With Asthma or Chronic Obstructive Pulmonary Disease. Am J Epidemiol. 2003 Apr 15;157(8):692-700. PubMed PMID: 12697573.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Conventional influenza vaccination is not associated with complications in working-age patients with asthma or chronic obstructive pulmonary disease. AU - Hak,E, AU - Hoes,A W, AU - Grobbee,D E, AU - Lammers,J W J, AU - van Essen,G A, AU - van Loon,A M, AU - Verheij,T J M, PY - 2003/4/17/pubmed PY - 2003/5/21/medline PY - 2003/4/17/entrez SP - 692 EP - 700 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 157 IS - 8 N2 - By using a nested case-control design, the authors studied the effectiveness of the influenza vaccine in reducing severe and fatal complications in 4,241 and 5,966 primary care, working-age patients aged 18-64 years who had asthma or chronic obstructive pulmonary disease during the 1998-1999 and 1999-2000 influenza epidemics in the Netherlands. Patients developing fatal or nonfatal exacerbations of lung disease, pneumonia, congestive heart failure, or myocardial infarction during either epidemic were considered cases. For each case, four age- and sex-matched controls were randomly sampled, and patient records were reviewed. Conditional logistic regression and propensity scores were used to assess vaccine effectiveness after adjustment for confounding factors. In seasons one and two, respectively, 87% (47/54) and 85% (171/202) of the cases and 74% (155/210) and 75% (575/766) of the controls had been vaccinated. After adjustments, vaccination was not associated with reductions in complications (season one: odds ratio = 0.95, 95% confidence interval (CI): 0.26, 3.48; season two: odds ratio = 1.07, 95% CI: 0.59, 1.96; pooled odds ratio = 1.07, 95% CI: 0.63, 1.80). Because influenza vaccination appeared not to be associated with a clinically relevant reduction in severe morbidity, other measures need to be explored. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/12697573/Conventional_influenza_vaccination_is_not_associated_with_complications_in_working_age_patients_with_asthma_or_chronic_obstructive_pulmonary_disease_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwg027 DB - PRIME DP - Unbound Medicine ER -