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The effect of betazole on serum group I pepsinogen levels: studies in symptomatic patients with and without recurrent ulcer after vagotomy and gastric resection or drainage.
Gastroenterology. 1976 Jun; 70(6):1007-13.G

Abstract

Serum group I pepsinogen (PG I) levels have been determined before and at intervals after the administration of betazole hydrochloride (Histalog) in 50 symptomatic postoperative patients, 20 with and 30 without recurrent ulcer, after either a vagotomy and gastric resection or a drainage procedure. In patients with recurrent ulcer, mean serum PG I levels increased after betazole and reached a maximum of 116.5 +/- 2.2% (SE) of basal at 2 hr; range 98.9 to 135.7%. In contrast, mean serum PG I levels decreased in patients without recurrent ulcer and reached a nadir of 75.0 +/- 4.3% of basal at 2 hr; range 46.9 to 142.4%. All 20 patients with recurrent ulcer and 5 patients without recurrence had a 2-hr serum PG I level of more than 98% of basal, while each of the remaining 25 patients without recurrent ulcer had a 2-hr level of less than 92% of basal. A 2-hr serum PG I level of more than 98% of basal was also correlated with a vagotomy and drainage, a peak acid output of more than 11 mEq per hr, and a positive insulin test, while a level of less than 92% of basal was correlated with a vagotomy and gastric resection, a peak acid output of less than 11 mEq per hr, and a negative insulin test. In addition, basal serum PG I and serum gastrin levels were significantly higher (P less than 0.001) in patients with the former type of PG I response than in those with the latter type of response. The cause of each type of response is not certain, but the data suggest that one of the determinants may be the completeness of vagotomy.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1269860

Citation

Samloff, I M., et al. "The Effect of Betazole On Serum Group I Pepsinogen Levels: Studies in Symptomatic Patients With and Without Recurrent Ulcer After Vagotomy and Gastric Resection or Drainage." Gastroenterology, vol. 70, no. 6, 1976, pp. 1007-13.
Samloff IM, Secrist DM, Passaro E. The effect of betazole on serum group I pepsinogen levels: studies in symptomatic patients with and without recurrent ulcer after vagotomy and gastric resection or drainage. Gastroenterology. 1976;70(6):1007-13.
Samloff, I. M., Secrist, D. M., & Passaro, E. (1976). The effect of betazole on serum group I pepsinogen levels: studies in symptomatic patients with and without recurrent ulcer after vagotomy and gastric resection or drainage. Gastroenterology, 70(6), 1007-13.
Samloff IM, Secrist DM, Passaro E. The Effect of Betazole On Serum Group I Pepsinogen Levels: Studies in Symptomatic Patients With and Without Recurrent Ulcer After Vagotomy and Gastric Resection or Drainage. Gastroenterology. 1976;70(6):1007-13. PubMed PMID: 1269860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of betazole on serum group I pepsinogen levels: studies in symptomatic patients with and without recurrent ulcer after vagotomy and gastric resection or drainage. AU - Samloff,I M, AU - Secrist,D M, AU - Passaro,E,Jr PY - 1976/6/11/pubmed PY - 2001/3/28/medline PY - 1976/6/11/entrez SP - 1007 EP - 13 JF - Gastroenterology JO - Gastroenterology VL - 70 IS - 6 N2 - Serum group I pepsinogen (PG I) levels have been determined before and at intervals after the administration of betazole hydrochloride (Histalog) in 50 symptomatic postoperative patients, 20 with and 30 without recurrent ulcer, after either a vagotomy and gastric resection or a drainage procedure. In patients with recurrent ulcer, mean serum PG I levels increased after betazole and reached a maximum of 116.5 +/- 2.2% (SE) of basal at 2 hr; range 98.9 to 135.7%. In contrast, mean serum PG I levels decreased in patients without recurrent ulcer and reached a nadir of 75.0 +/- 4.3% of basal at 2 hr; range 46.9 to 142.4%. All 20 patients with recurrent ulcer and 5 patients without recurrence had a 2-hr serum PG I level of more than 98% of basal, while each of the remaining 25 patients without recurrent ulcer had a 2-hr level of less than 92% of basal. A 2-hr serum PG I level of more than 98% of basal was also correlated with a vagotomy and drainage, a peak acid output of more than 11 mEq per hr, and a positive insulin test, while a level of less than 92% of basal was correlated with a vagotomy and gastric resection, a peak acid output of less than 11 mEq per hr, and a negative insulin test. In addition, basal serum PG I and serum gastrin levels were significantly higher (P less than 0.001) in patients with the former type of PG I response than in those with the latter type of response. The cause of each type of response is not certain, but the data suggest that one of the determinants may be the completeness of vagotomy. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/1269860/The_effect_of_betazole_on_serum_group_I_pepsinogen_levels:_studies_in_symptomatic_patients_with_and_without_recurrent_ulcer_after_vagotomy_and_gastric_resection_or_drainage_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016508576001285 DB - PRIME DP - Unbound Medicine ER -