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Elevated serum TNF-alpha levels in normal-weight women with polycystic ovaries or the polycystic ovary syndrome.
J Reprod Med. 2003 Mar; 48(3):165-70.JR

Abstract

OBJECTIVE

To compare the serum tumor necrosis factor-alpha (TNF-alpha) levels in nonobese women with those in women with polycystic ovaries (PCO) and polycystic ovary syndrome (PCOS) and healthy controls.

STUDY DESIGN

Twenty-one sonographically and biochemically diagnosed women with PCOS, 19 with PCO and 14 healthy women were recruited for the study. Serum TNF-alpha levels were measured in all three groups. Insulin and glucose serum concentrations were analyzed before and after a 75-g oral glucose tolerance test in all samples. The serum TNF-alpha, glucose and insulin levels were compared in PCOS, PCO and controls.

RESULTS

Serum TNF-alpha levels were similar in the PCOS and PCO groups (23.67 +/- 5.58 and 13.58 +/- 1.34 pg/mL, respectively) and significantly higher than in the control group. Serum TNF-alpha levels did not significantly correlated with body mass index, serum total testosterone, LH, DHEAS, fasting glucose and fasting insulin levels or glucose and insulin area under the curve values in the three groups.

CONCLUSION

We found similar TNF-alpha levels in patients with PCOS and with PCO; however, there was no correlation between the TNF-alpha and insulin, glucose and androgen levels in the study.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Faculty of Medicine, Trakya University, 22030, Edirne, Turkey. ncsayin@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12698773

Citation

Sayin, N Cenk, et al. "Elevated Serum TNF-alpha Levels in Normal-weight Women With Polycystic Ovaries or the Polycystic Ovary Syndrome." The Journal of Reproductive Medicine, vol. 48, no. 3, 2003, pp. 165-70.
Sayin NC, Gücer F, Balkanli-Kaplan P, et al. Elevated serum TNF-alpha levels in normal-weight women with polycystic ovaries or the polycystic ovary syndrome. J Reprod Med. 2003;48(3):165-70.
Sayin, N. C., Gücer, F., Balkanli-Kaplan, P., Yüce, M. A., Ciftci, S., Kücük, M., & Yardim, T. (2003). Elevated serum TNF-alpha levels in normal-weight women with polycystic ovaries or the polycystic ovary syndrome. The Journal of Reproductive Medicine, 48(3), 165-70.
Sayin NC, et al. Elevated Serum TNF-alpha Levels in Normal-weight Women With Polycystic Ovaries or the Polycystic Ovary Syndrome. J Reprod Med. 2003;48(3):165-70. PubMed PMID: 12698773.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated serum TNF-alpha levels in normal-weight women with polycystic ovaries or the polycystic ovary syndrome. AU - Sayin,N Cenk, AU - Gücer,Fatih, AU - Balkanli-Kaplan,Petek, AU - Yüce,M Ali, AU - Ciftci,Sentürk, AU - Kücük,Mustafa, AU - Yardim,Turgut, PY - 2003/4/18/pubmed PY - 2003/7/3/medline PY - 2003/4/18/entrez SP - 165 EP - 70 JF - The Journal of reproductive medicine JO - J Reprod Med VL - 48 IS - 3 N2 - OBJECTIVE: To compare the serum tumor necrosis factor-alpha (TNF-alpha) levels in nonobese women with those in women with polycystic ovaries (PCO) and polycystic ovary syndrome (PCOS) and healthy controls. STUDY DESIGN: Twenty-one sonographically and biochemically diagnosed women with PCOS, 19 with PCO and 14 healthy women were recruited for the study. Serum TNF-alpha levels were measured in all three groups. Insulin and glucose serum concentrations were analyzed before and after a 75-g oral glucose tolerance test in all samples. The serum TNF-alpha, glucose and insulin levels were compared in PCOS, PCO and controls. RESULTS: Serum TNF-alpha levels were similar in the PCOS and PCO groups (23.67 +/- 5.58 and 13.58 +/- 1.34 pg/mL, respectively) and significantly higher than in the control group. Serum TNF-alpha levels did not significantly correlated with body mass index, serum total testosterone, LH, DHEAS, fasting glucose and fasting insulin levels or glucose and insulin area under the curve values in the three groups. CONCLUSION: We found similar TNF-alpha levels in patients with PCOS and with PCO; however, there was no correlation between the TNF-alpha and insulin, glucose and androgen levels in the study. SN - 0024-7758 UR - https://www.unboundmedicine.com/medline/citation/12698773/Elevated_serum_TNF_alpha_levels_in_normal_weight_women_with_polycystic_ovaries_or_the_polycystic_ovary_syndrome_ L2 - https://medlineplus.gov/polycysticovarysyndrome.html DB - PRIME DP - Unbound Medicine ER -