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Intrasellar schwannomas: report of two cases.
Neurosurgery. 2003 May; 52(5):1200-5; discussion 1205-6.N

Abstract

OBJECTIVE AND IMPORTANCE

The complex regional anatomic features surrounding the sella turcica make the differential diagnosis of intrasellar and parasellar lesions complicated. Sellar and parasellar schwannomas are rare. With the exclusion of parasellar schwannomas arising from cranial nerves within the cavernous sinus and extending into the sella, there have been only two reported cases of true intrasellar schwannomas.

CLINICAL PRESENTATION

We describe the clinical, radiological, and pathological features of two cases in which the histopathological diagnosis of schwannoma was confirmed with immunohistochemical analyses and/or electron microscopy.

INTERVENTION

The two cases were grossly resected via a transsphenoidal approach. Follow-up monitoring revealed no evidence of recurrence.

CONCLUSION

Schwannomas may atypically occur in the sellar region, in which they demonstrate the typical light microscopic, immunohistochemical, and ultrastructural features observed in the peripheral nervous system. New and existing hypotheses regarding the histopathogenesis of intrasellar and parasellar schwannomas are presented.

Authors+Show Affiliations

Maartens NF
Department of Neurosurgery, The Royal Melbourne Hospital, Melbourne, Victoria, Australia.
Ellegala DB
No affiliation info available
Vance ML
No affiliation info available
Lopes MB
No affiliation info available
Laws ER
No affiliation info available

MeSH

AdultFemaleHumansMagnetic Resonance ImagingMiddle AgedNeurilemmomaPituitary NeoplasmsSella TurcicaTomography, X-Ray Computed

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

12699566

Citation

Maartens, Nicholas F., et al. "Intrasellar Schwannomas: Report of Two Cases." Neurosurgery, vol. 52, no. 5, 2003, pp. 1200-5; discussion 1205-6.
Maartens NF, Ellegala DB, Vance ML, et al. Intrasellar schwannomas: report of two cases. Neurosurgery. 2003;52(5):1200-5; discussion 1205-6.
Maartens, N. F., Ellegala, D. B., Vance, M. L., Lopes, M. B., & Laws, E. R. (2003). Intrasellar schwannomas: report of two cases. Neurosurgery, 52(5), 1200-5; discussion 1205-6.
Maartens NF, et al. Intrasellar Schwannomas: Report of Two Cases. Neurosurgery. 2003;52(5):1200-5; discussion 1205-6. PubMed PMID: 12699566.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intrasellar schwannomas: report of two cases. AU - Maartens,Nicholas F, AU - Ellegala,Dilantha B, AU - Vance,Mary Lee, AU - Lopes,M Beatriz S, AU - Laws,Edward R,Jr PY - 2002/08/02/received PY - 2002/12/23/accepted PY - 2003/4/18/pubmed PY - 2003/6/26/medline PY - 2003/4/18/entrez SP - 1200-5; discussion 1205-6 JF - Neurosurgery JO - Neurosurgery VL - 52 IS - 5 N2 - OBJECTIVE AND IMPORTANCE: The complex regional anatomic features surrounding the sella turcica make the differential diagnosis of intrasellar and parasellar lesions complicated. Sellar and parasellar schwannomas are rare. With the exclusion of parasellar schwannomas arising from cranial nerves within the cavernous sinus and extending into the sella, there have been only two reported cases of true intrasellar schwannomas. CLINICAL PRESENTATION: We describe the clinical, radiological, and pathological features of two cases in which the histopathological diagnosis of schwannoma was confirmed with immunohistochemical analyses and/or electron microscopy. INTERVENTION: The two cases were grossly resected via a transsphenoidal approach. Follow-up monitoring revealed no evidence of recurrence. CONCLUSION: Schwannomas may atypically occur in the sellar region, in which they demonstrate the typical light microscopic, immunohistochemical, and ultrastructural features observed in the peripheral nervous system. New and existing hypotheses regarding the histopathogenesis of intrasellar and parasellar schwannomas are presented. SN - 0148-396X UR - https://www.unboundmedicine.com/medline/citation/12699566/Intrasellar_schwannomas:_report_of_two_cases_ DB - PRIME DP - Unbound Medicine ER -