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Iron status at 12 months of age -- effects of body size, growth and diet in a population with high birth weight.
Eur J Clin Nutr. 2003 Apr; 57(4):505-13.EJ

Abstract

OBJECTIVE

To investigate effects of growth and food intake in infancy on iron status at the age of 12 months in a population with high birth weight and high frequency of breast-feeding.

DESIGN

In a longitudinal observational study infants' consumption and growth were recorded. Weighed 2 day food records at the ages of 6, 9 and 12 months were used to analyse food and nutrient intake.

SETTING

Healthy-born participants were recruited from four maternity wards. Blood samples and growth data were collected from healthcare centres and food consumption data at home.

SUBJECTS

Newborn infants (n=180) were selected randomly according to the mother's domicile and 77% (n=138) participated, of them, 83% (n=114), or 63% of original sample, came in for blood sampling.

RESULTS

Every fifth child was iron-deficient (serum ferritin <12 microg/l and mean corpuscular volume<74 fl) and 2.7% were also anaemic (Hb<105 g/l). Higher weight gain from 0 to 12 months was seen in infants who were iron-deficient at 12 months (6.7+/-0.9 kg) than in non-iron-deficient infants (6.2+/-0.9 kg) (P=0.050). Serum transferrin receptors at 12 months were positively associated with length gain from 0 to 12 months (adjusted r(2)=0.14; P=0.045) and mean corpuscular volume negatively to ponderal index at birth (adjusted r(2)=0.14; P=0.019) and 12 months (adjusted r(2)=0.17; P=0.006). Iron-deficient infants had shorter breast-feeding duration (5.3+/-2.2 months) than non-iron-deficient (7.9+/-3.2 months; P=0.001). Iron status indices were negatively associated with cow's milk consumption at 9-12 months, significant above 460 g/day, but were positively associated with iron-fortified breakfast cereals, fish and meat consumption.

CONCLUSIONS

: In a population of high birth weight, iron deficiency at 12 months is associated with faster growth and shorter breast-feeding duration from 0 to 12 months of age. The results suggest that a diet of 9-12-month-olds should avoid cow's milk above 500 g/day and include fish, meat and iron-fortified breakfast cereals to improve iron status.

Authors+Show Affiliations

Thorsdottir I
Landspitali University Hospital and Department of Food Science, University of Iceland, Reykjavik, Iceland. ingathor@landspitali.is
Gunnarsson BS
No affiliation info available
Atladottir H
No affiliation info available
Michaelsen KF
No affiliation info available
Palsson G
No affiliation info available

MeSH

AgingAnimalsBirth WeightBody ConstitutionBody HeightBreast FeedingDietEdible GrainFerritinsFishesFood, FortifiedGrowthHumansInfantIronIron DeficienciesMeatMilkNutritional StatusReceptors, TransferrinTime FactorsWeight Gain

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12700611

Citation

Thorsdottir, I, et al. "Iron Status at 12 Months of Age -- Effects of Body Size, Growth and Diet in a Population With High Birth Weight." European Journal of Clinical Nutrition, vol. 57, no. 4, 2003, pp. 505-13.
Thorsdottir I, Gunnarsson BS, Atladottir H, et al. Iron status at 12 months of age -- effects of body size, growth and diet in a population with high birth weight. Eur J Clin Nutr. 2003;57(4):505-13.
Thorsdottir, I., Gunnarsson, B. S., Atladottir, H., Michaelsen, K. F., & Palsson, G. (2003). Iron status at 12 months of age -- effects of body size, growth and diet in a population with high birth weight. European Journal of Clinical Nutrition, 57(4), 505-13.
Thorsdottir I, et al. Iron Status at 12 Months of Age -- Effects of Body Size, Growth and Diet in a Population With High Birth Weight. Eur J Clin Nutr. 2003;57(4):505-13. PubMed PMID: 12700611.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Iron status at 12 months of age -- effects of body size, growth and diet in a population with high birth weight. AU - Thorsdottir,I, AU - Gunnarsson,B S, AU - Atladottir,H, AU - Michaelsen,K F, AU - Palsson,G, PY - 2002/01/14/received PY - 2002/04/06/revised PY - 2002/07/15/accepted PY - 2003/4/18/pubmed PY - 2003/8/2/medline PY - 2003/4/18/entrez SP - 505 EP - 13 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 57 IS - 4 N2 - OBJECTIVE: To investigate effects of growth and food intake in infancy on iron status at the age of 12 months in a population with high birth weight and high frequency of breast-feeding. DESIGN: In a longitudinal observational study infants' consumption and growth were recorded. Weighed 2 day food records at the ages of 6, 9 and 12 months were used to analyse food and nutrient intake. SETTING: Healthy-born participants were recruited from four maternity wards. Blood samples and growth data were collected from healthcare centres and food consumption data at home. SUBJECTS: Newborn infants (n=180) were selected randomly according to the mother's domicile and 77% (n=138) participated, of them, 83% (n=114), or 63% of original sample, came in for blood sampling. RESULTS: Every fifth child was iron-deficient (serum ferritin <12 microg/l and mean corpuscular volume<74 fl) and 2.7% were also anaemic (Hb<105 g/l). Higher weight gain from 0 to 12 months was seen in infants who were iron-deficient at 12 months (6.7+/-0.9 kg) than in non-iron-deficient infants (6.2+/-0.9 kg) (P=0.050). Serum transferrin receptors at 12 months were positively associated with length gain from 0 to 12 months (adjusted r(2)=0.14; P=0.045) and mean corpuscular volume negatively to ponderal index at birth (adjusted r(2)=0.14; P=0.019) and 12 months (adjusted r(2)=0.17; P=0.006). Iron-deficient infants had shorter breast-feeding duration (5.3+/-2.2 months) than non-iron-deficient (7.9+/-3.2 months; P=0.001). Iron status indices were negatively associated with cow's milk consumption at 9-12 months, significant above 460 g/day, but were positively associated with iron-fortified breakfast cereals, fish and meat consumption. CONCLUSIONS: : In a population of high birth weight, iron deficiency at 12 months is associated with faster growth and shorter breast-feeding duration from 0 to 12 months of age. The results suggest that a diet of 9-12-month-olds should avoid cow's milk above 500 g/day and include fish, meat and iron-fortified breakfast cereals to improve iron status. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/12700611/Iron_status_at_12_months_of_age____effects_of_body_size_growth_and_diet_in_a_population_with_high_birth_weight_ DB - PRIME DP - Unbound Medicine ER -