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A novel soy-based meal replacement formula for weight loss among obese individuals: a randomized controlled clinical trial.
Eur J Clin Nutr. 2003 Apr; 57(4):514-22.EJ

Abstract

OBJECTIVE

To assess the efficacy and safety of a low calorie soy-based meal replacement program for the treatment of obesity.

DESIGN

A 12-week prospective randomized controlled clinical trial.

SETTING

Outpatient weight control research unit.

SUBJECTS

One hundred obese (28<BMI<or=41 kg/m(2)) volunteers between the ages of 35 and 65 y. Seventy-four participants completed the trial.

INTERVENTION

Participants were randomized to either the meal replacement treatment group (n=50; 240 g/day, 1200 kcal/day) or control group (n=50). Both groups at baseline received a single dietary counseling session and a pamphlet describing weight loss practices.

MAIN OUTCOME MEASURES

Weight, body fat, serum lipid concentrations.

RESULTS

: By intent-to-treat analysis, the treatment group lost significantly more weight than the control group (7.00 vs 2.90 kg; P<0.001) and had a greater change in total (22.5 vs 6.8 mg/dl; P=0.013) and LDL cholesterol (21.2 vs 7.1 mg/dl; P<0.009). Among completers only, the treatment group again lost more weight (7.1 kg; n=37 vs 2.9 kg; n=37; P=0.0001) and had a greater reduction in total cholesterol (26.1 mg/dl; n=37 vs 6.7 mg/dl; P=0.0012) and a greater change in LDL cholesterol (21.6 vs 5.5 mg/dl; P=0.0025). (For any given degree of weight loss, the reduction in LDL cholesterol was significantly greater in the treatment group.) Treatment was well tolerated and no serious side effects were detected.

CONCLUSIONS

Use of this soy-based meal replacement formula was effective in lowering body weight, fat mass and in reducing LDL cholesterol beyond what could be expected given the weight lost.

Authors+Show Affiliations

Department of Biostatistics and Center for Research on Clinical Nutrition, University of Alabama at Birmingham, Birmingham, Alabama 35294-0022, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12700612

Citation

Allison, D B., et al. "A Novel Soy-based Meal Replacement Formula for Weight Loss Among Obese Individuals: a Randomized Controlled Clinical Trial." European Journal of Clinical Nutrition, vol. 57, no. 4, 2003, pp. 514-22.
Allison DB, Gadbury G, Schwartz LG, et al. A novel soy-based meal replacement formula for weight loss among obese individuals: a randomized controlled clinical trial. Eur J Clin Nutr. 2003;57(4):514-22.
Allison, D. B., Gadbury, G., Schwartz, L. G., Murugesan, R., Kraker, J. L., Heshka, S., Fontaine, K. R., & Heymsfield, S. B. (2003). A novel soy-based meal replacement formula for weight loss among obese individuals: a randomized controlled clinical trial. European Journal of Clinical Nutrition, 57(4), 514-22.
Allison DB, et al. A Novel Soy-based Meal Replacement Formula for Weight Loss Among Obese Individuals: a Randomized Controlled Clinical Trial. Eur J Clin Nutr. 2003;57(4):514-22. PubMed PMID: 12700612.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A novel soy-based meal replacement formula for weight loss among obese individuals: a randomized controlled clinical trial. AU - Allison,D B, AU - Gadbury,G, AU - Schwartz,L G, AU - Murugesan,R, AU - Kraker,J L, AU - Heshka,S, AU - Fontaine,K R, AU - Heymsfield,S B, PY - 2002/02/28/received PY - 2002/06/20/revised PY - 2002/06/26/accepted PY - 2003/4/18/pubmed PY - 2003/8/2/medline PY - 2003/4/18/entrez SP - 514 EP - 22 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 57 IS - 4 N2 - OBJECTIVE: To assess the efficacy and safety of a low calorie soy-based meal replacement program for the treatment of obesity. DESIGN: A 12-week prospective randomized controlled clinical trial. SETTING: Outpatient weight control research unit. SUBJECTS: One hundred obese (28<BMI<or=41 kg/m(2)) volunteers between the ages of 35 and 65 y. Seventy-four participants completed the trial. INTERVENTION: Participants were randomized to either the meal replacement treatment group (n=50; 240 g/day, 1200 kcal/day) or control group (n=50). Both groups at baseline received a single dietary counseling session and a pamphlet describing weight loss practices. MAIN OUTCOME MEASURES: Weight, body fat, serum lipid concentrations. RESULTS: : By intent-to-treat analysis, the treatment group lost significantly more weight than the control group (7.00 vs 2.90 kg; P<0.001) and had a greater change in total (22.5 vs 6.8 mg/dl; P=0.013) and LDL cholesterol (21.2 vs 7.1 mg/dl; P<0.009). Among completers only, the treatment group again lost more weight (7.1 kg; n=37 vs 2.9 kg; n=37; P=0.0001) and had a greater reduction in total cholesterol (26.1 mg/dl; n=37 vs 6.7 mg/dl; P=0.0012) and a greater change in LDL cholesterol (21.6 vs 5.5 mg/dl; P=0.0025). (For any given degree of weight loss, the reduction in LDL cholesterol was significantly greater in the treatment group.) Treatment was well tolerated and no serious side effects were detected. CONCLUSIONS: Use of this soy-based meal replacement formula was effective in lowering body weight, fat mass and in reducing LDL cholesterol beyond what could be expected given the weight lost. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/12700612/A_novel_soy_based_meal_replacement_formula_for_weight_loss_among_obese_individuals:_a_randomized_controlled_clinical_trial_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1601587 DB - PRIME DP - Unbound Medicine ER -