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Long-term follow-up of patients with endoscopic treatment of sporadic adenomas of the papilla of vater.
Endoscopy 2003; 35(5):402-6E

Abstract

BACKGROUND AND STUDY AIMS

Knowledge about the long-term outcome of patients after endoscopic treatment of ampullary adenomas remains poor, although surgical series have suggested that the initial endoscopic evaluation of these diseases might overlook cancer foci developed in adenomas. The aim of this study was to evaluate retrospectively the long-term outcome in patients with ampullary adenomas treated endoscopically, with a focus on the possible development of cancer.

PATIENTS AND METHODS

The study included 24 patients (median age 59 years, range 34 - 84) with macroscopically benign adenomas of the papilla of Vater treated using mainly laser photodestruction between 1983 and 1996. Medical, endoscopic, surgical, and histological reports were reviewed. Patients and general practitioners were contacted to determine patient outcome when endoscopic follow-up had been discontinued.

RESULTS

Endoscopic remission (macroscopic and histological) was achieved in 16 patients (66.6 %) with one recurrence (6.2 %) during a mean endoscopic follow-up of 66 months (4-168 months). Endoscopic treatment was discontinued in five (20.8 %) patients (with minimal residual adenoma and advanced age and/or severe unrelated disease), and failed in three patients (12.5 %) (failure of Nd:YAG laser in one case, severe pancreatitis and pancreatic duct ingrowth in one case each). After a mean clinical follow-up of 81 months (8-172 months), two patients (8.3 %) had undergone pancreaticoduodenectomy; eight (33.3 %) had died from unrelated diseases; and 14 (58.3 %) were alive and asymptomatic without any evidence of ampullary cancer.

CONCLUSIONS

Long-term follow-up revealed no case of advanced ampullary cancer and suggested that endoscopic treatment was satisfactory for the large majority of patients with ampullary adenomas.

Authors+Show Affiliations

Fédération des Spécialités Digestives, Pavillon I, Hôpital E. Herriot, Lyon, Lyon, France. saurin@lyon.inserm.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12701011

Citation

Saurin, J-C, et al. "Long-term Follow-up of Patients With Endoscopic Treatment of Sporadic Adenomas of the Papilla of Vater." Endoscopy, vol. 35, no. 5, 2003, pp. 402-6.
Saurin JC, Chavaillon A, Napoléon B, et al. Long-term follow-up of patients with endoscopic treatment of sporadic adenomas of the papilla of vater. Endoscopy. 2003;35(5):402-6.
Saurin, J. C., Chavaillon, A., Napoléon, B., Descos, F., Bory, R., Berger, F., & Ponchon, T. (2003). Long-term follow-up of patients with endoscopic treatment of sporadic adenomas of the papilla of vater. Endoscopy, 35(5), pp. 402-6.
Saurin JC, et al. Long-term Follow-up of Patients With Endoscopic Treatment of Sporadic Adenomas of the Papilla of Vater. Endoscopy. 2003;35(5):402-6. PubMed PMID: 12701011.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term follow-up of patients with endoscopic treatment of sporadic adenomas of the papilla of vater. AU - Saurin,J-C, AU - Chavaillon,A, AU - Napoléon,B, AU - Descos,F, AU - Bory,R, AU - Berger,F, AU - Ponchon,T, PY - 2003/4/18/pubmed PY - 2003/8/15/medline PY - 2003/4/18/entrez SP - 402 EP - 6 JF - Endoscopy JO - Endoscopy VL - 35 IS - 5 N2 - BACKGROUND AND STUDY AIMS: Knowledge about the long-term outcome of patients after endoscopic treatment of ampullary adenomas remains poor, although surgical series have suggested that the initial endoscopic evaluation of these diseases might overlook cancer foci developed in adenomas. The aim of this study was to evaluate retrospectively the long-term outcome in patients with ampullary adenomas treated endoscopically, with a focus on the possible development of cancer. PATIENTS AND METHODS: The study included 24 patients (median age 59 years, range 34 - 84) with macroscopically benign adenomas of the papilla of Vater treated using mainly laser photodestruction between 1983 and 1996. Medical, endoscopic, surgical, and histological reports were reviewed. Patients and general practitioners were contacted to determine patient outcome when endoscopic follow-up had been discontinued. RESULTS: Endoscopic remission (macroscopic and histological) was achieved in 16 patients (66.6 %) with one recurrence (6.2 %) during a mean endoscopic follow-up of 66 months (4-168 months). Endoscopic treatment was discontinued in five (20.8 %) patients (with minimal residual adenoma and advanced age and/or severe unrelated disease), and failed in three patients (12.5 %) (failure of Nd:YAG laser in one case, severe pancreatitis and pancreatic duct ingrowth in one case each). After a mean clinical follow-up of 81 months (8-172 months), two patients (8.3 %) had undergone pancreaticoduodenectomy; eight (33.3 %) had died from unrelated diseases; and 14 (58.3 %) were alive and asymptomatic without any evidence of ampullary cancer. CONCLUSIONS: Long-term follow-up revealed no case of advanced ampullary cancer and suggested that endoscopic treatment was satisfactory for the large majority of patients with ampullary adenomas. SN - 0013-726X UR - https://www.unboundmedicine.com/medline/citation/12701011/Long_term_follow_up_of_patients_with_endoscopic_treatment_of_sporadic_adenomas_of_the_papilla_of_vater_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2003-38767 DB - PRIME DP - Unbound Medicine ER -