Tags

Type your tag names separated by a space and hit enter

Evolution and phylogenetic relationships of chitin synthases from yeasts and fungi.
FEMS Yeast Res. 2002 Jan; 1(4):247-56.FY

Abstract

Chitin, the structural component that provides rigidity to the cell wall of fungi is the product of chitin synthases (Chs). These enzymes are not restricted to fungi, but are amply distributed in four of the five eukaryotic 'crown kingdoms'. Dendrograms obtained by multiple alignment of Chs revealed that fungal enzymes can be classified into two divisions that branch into at least five classes, independent of fungal divergence. In contrast, oomycetes and animals each possess a single family of Chs. These results suggest that Chs originated as a branch of beta-glycosyl-transferases, once the kingdom Plantae split from the evolutionary line of eukaryotes. The existence of a single class of Chs in animals and Stramenopiles, against the multiple families in fungi, reveals that Chs diversification occurred after fungi departed from these kingdoms, but before separation of fungal groups. Accordingly, each fungal taxon contains members with enzymes belonging to different divisions and classes. Multiple alignment revealed the conservation of specific motifs characteristic of class, division and kingdom, but the strict conservation of only three motifs QXXEY, EDRXL and QXRRW, and seven isolated amino acids in the core region of all Chs. Determination of different structural features in this region of Chs brought to light a noticeable conservation of secondary structure in the proteins.

Authors+Show Affiliations

Departamento de Ingeniería Genética, Unidad Irapuato, Centro de Investigación y de Estudios Avanzados del IPN, Carretera Irapuato-León, Gto. Mexico. jruiz@ira.cinvestav.mxNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

12702327

Citation

Ruiz-Herrera, José, et al. "Evolution and Phylogenetic Relationships of Chitin Synthases From Yeasts and Fungi." FEMS Yeast Research, vol. 1, no. 4, 2002, pp. 247-56.
Ruiz-Herrera J, González-Prieto JM, Ruiz-Medrano R. Evolution and phylogenetic relationships of chitin synthases from yeasts and fungi. FEMS Yeast Res. 2002;1(4):247-56.
Ruiz-Herrera, J., González-Prieto, J. M., & Ruiz-Medrano, R. (2002). Evolution and phylogenetic relationships of chitin synthases from yeasts and fungi. FEMS Yeast Research, 1(4), 247-56.
Ruiz-Herrera J, González-Prieto JM, Ruiz-Medrano R. Evolution and Phylogenetic Relationships of Chitin Synthases From Yeasts and Fungi. FEMS Yeast Res. 2002;1(4):247-56. PubMed PMID: 12702327.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evolution and phylogenetic relationships of chitin synthases from yeasts and fungi. AU - Ruiz-Herrera,José, AU - González-Prieto,Juan Manuel, AU - Ruiz-Medrano,Roberto, PY - 2003/4/19/pubmed PY - 2003/6/14/medline PY - 2003/4/19/entrez SP - 247 EP - 56 JF - FEMS yeast research JO - FEMS Yeast Res. VL - 1 IS - 4 N2 - Chitin, the structural component that provides rigidity to the cell wall of fungi is the product of chitin synthases (Chs). These enzymes are not restricted to fungi, but are amply distributed in four of the five eukaryotic 'crown kingdoms'. Dendrograms obtained by multiple alignment of Chs revealed that fungal enzymes can be classified into two divisions that branch into at least five classes, independent of fungal divergence. In contrast, oomycetes and animals each possess a single family of Chs. These results suggest that Chs originated as a branch of beta-glycosyl-transferases, once the kingdom Plantae split from the evolutionary line of eukaryotes. The existence of a single class of Chs in animals and Stramenopiles, against the multiple families in fungi, reveals that Chs diversification occurred after fungi departed from these kingdoms, but before separation of fungal groups. Accordingly, each fungal taxon contains members with enzymes belonging to different divisions and classes. Multiple alignment revealed the conservation of specific motifs characteristic of class, division and kingdom, but the strict conservation of only three motifs QXXEY, EDRXL and QXRRW, and seven isolated amino acids in the core region of all Chs. Determination of different structural features in this region of Chs brought to light a noticeable conservation of secondary structure in the proteins. SN - 1567-1356 UR - https://www.unboundmedicine.com/medline/citation/12702327/Evolution_and_phylogenetic_relationships_of_chitin_synthases_from_yeasts_and_fungi_ L2 - https://academic.oup.com/femsyr/article-lookup/doi/10.1111/j.1567-1364.2002.tb00042.x DB - PRIME DP - Unbound Medicine ER -