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High prevalence of coeliac disease in apparently healthy Iranian blood donors.
Eur J Gastroenterol Hepatol 2003; 15(5):475-8EJ

Abstract

BACKGROUND/OBJECTIVE

Studies about the prevalence of coeliac disease in countries in western Asia are scarce and there is no study on the prevalence of coeliac disease in Iran. The aim of this study was to determine the prevalence of coeliac in healthy, Iranian, blood donors.

STUDY DESIGN AND METHODS

Blood samples were obtained from 2000 apparently healthy blood donors (1580 males, 420 females; mean age 35.5 years, range 18-65 years) at the Tehran Blood Donation Centre during a 4 month period from November 1998 through February 1999. Total serum IgA was measured in all donors, and IgA deficient cases were excluded. All cases were analysed for IgA anti-gliadin (AGA) by an ELISA test and those with positive results were tested for IgA anti-endomysium antibody (EMA) using immunofluorescence. All donors who had a positive serology for both AGA and EMA underwent small intestinal biopsy. The biopsy samples were classified according to revised Marsh criteria (UEGW 2001).

RESULTS

Forty-nine cases showed positive IgA AGA (38 males and 11 females, mean age 38.6 years). Of the 49 AGA positive cases 12 were EMA positive. All subjects with positive serology (both AGA and EMA) were found to have small bowel biopsies compatible with gluten sensitive enteropathy. Three of 12 had Marsh I, 4/12 Marsh II and 5/12 showed a Marsh IIIa lesion.

CONCLUSION

The minimum prevalence of gluten sensitivity among apparently healthy urban Iranian blood donors is 1/166. Further epidemiological studies in adults from the general population and in high risk groups seems indicated.

Authors+Show Affiliations

Digestive Disease Research Centre, Tehran University of Medical Sciences, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12702902

Citation

Shahbazkhani, Bijan, et al. "High Prevalence of Coeliac Disease in Apparently Healthy Iranian Blood Donors." European Journal of Gastroenterology & Hepatology, vol. 15, no. 5, 2003, pp. 475-8.
Shahbazkhani B, Malekzadeh R, Sotoudeh M, et al. High prevalence of coeliac disease in apparently healthy Iranian blood donors. Eur J Gastroenterol Hepatol. 2003;15(5):475-8.
Shahbazkhani, B., Malekzadeh, R., Sotoudeh, M., Moghadam, K. F., Farhadi, M., Ansari, R., ... Rostami, K. (2003). High prevalence of coeliac disease in apparently healthy Iranian blood donors. European Journal of Gastroenterology & Hepatology, 15(5), pp. 475-8.
Shahbazkhani B, et al. High Prevalence of Coeliac Disease in Apparently Healthy Iranian Blood Donors. Eur J Gastroenterol Hepatol. 2003;15(5):475-8. PubMed PMID: 12702902.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High prevalence of coeliac disease in apparently healthy Iranian blood donors. AU - Shahbazkhani,Bijan, AU - Malekzadeh,Reza, AU - Sotoudeh,Masoud, AU - Moghadam,Ketaion Fayaz, AU - Farhadi,Mohammad, AU - Ansari,Reza, AU - Elahyfar,Amin, AU - Rostami,Kamran, PY - 2003/4/19/pubmed PY - 2003/7/15/medline PY - 2003/4/19/entrez SP - 475 EP - 8 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 15 IS - 5 N2 - BACKGROUND/OBJECTIVE: Studies about the prevalence of coeliac disease in countries in western Asia are scarce and there is no study on the prevalence of coeliac disease in Iran. The aim of this study was to determine the prevalence of coeliac in healthy, Iranian, blood donors. STUDY DESIGN AND METHODS: Blood samples were obtained from 2000 apparently healthy blood donors (1580 males, 420 females; mean age 35.5 years, range 18-65 years) at the Tehran Blood Donation Centre during a 4 month period from November 1998 through February 1999. Total serum IgA was measured in all donors, and IgA deficient cases were excluded. All cases were analysed for IgA anti-gliadin (AGA) by an ELISA test and those with positive results were tested for IgA anti-endomysium antibody (EMA) using immunofluorescence. All donors who had a positive serology for both AGA and EMA underwent small intestinal biopsy. The biopsy samples were classified according to revised Marsh criteria (UEGW 2001). RESULTS: Forty-nine cases showed positive IgA AGA (38 males and 11 females, mean age 38.6 years). Of the 49 AGA positive cases 12 were EMA positive. All subjects with positive serology (both AGA and EMA) were found to have small bowel biopsies compatible with gluten sensitive enteropathy. Three of 12 had Marsh I, 4/12 Marsh II and 5/12 showed a Marsh IIIa lesion. CONCLUSION: The minimum prevalence of gluten sensitivity among apparently healthy urban Iranian blood donors is 1/166. Further epidemiological studies in adults from the general population and in high risk groups seems indicated. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/12702902/High_prevalence_of_coeliac_disease_in_apparently_healthy_Iranian_blood_donors_ L2 - http://Insights.ovid.com/pubmed?pmid=12702902 DB - PRIME DP - Unbound Medicine ER -