Tags

Type your tag names separated by a space and hit enter

Incidence and clinical characteristics of the metabolic syndrome in patients with coronary artery disease.
Coron Artery Dis. 2003 May; 14(3):207-12.CA

Abstract

BACKGROUND AND OBJECTIVES

Several studies suggested that the insulin resistance-associated metabolic syndrome (MS) is a major risk factor for coronary artery disease (CAD), but the criteria to identify MS were only recently standardized by the National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III.

METHODS

We evaluated the incidence of the newly defined MS in patients with documented CAD and compared the characteristics of patients with and without this syndrome.

RESULTS

In a Canadian population with CAD (793 men and 315 women, age 58.1+/-9.8 years) 51% had MS. As compared to patients without the MS syndrome, these patients had significantly higher waist circumference, blood pressure levels and fasting glucose and triglyceride, but lower high-density lipoprotein (HDL)-cholesterol levels. Their homeostatic model assessment (HOMA) insulin resistance index was significantly higher, with indicators of highly atherogenic, small low-density lipoprotein (LDL) and HDL particles. Family history of diabetes and the use of hypoglycemic agents, beta-blockers and thiazides were more frequent, but physical exercise and alcohol consumption were less frequent in MS positive patients. Cumulative coronary stenosis score and the frequency of patients with >50% coronary artery narrowing were higher and there was a strong tendency for higher rates of previous myocardial infarction in MS positive patients.

CONCLUSIONS

In a CAD population documented in 1991-1992, 51% of participants had MS and in several respects a more advanced coronary disease than those without the syndrome. These results support the view of NCEP ATP III, that in CAD prevention, beyond lowering LDL-cholesterol levels, interventions concerning the constituents of MS should be important.

Authors+Show Affiliations

Research Center, Montreal Heart Institute, 5000 Belanger Street East, Montreal, Quebec H1T 1C8, Canada. solymoss@icm.umontreal.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

12702923

Citation

Solymoss, Bela C., et al. "Incidence and Clinical Characteristics of the Metabolic Syndrome in Patients With Coronary Artery Disease." Coronary Artery Disease, vol. 14, no. 3, 2003, pp. 207-12.
Solymoss BC, Bourassa MG, Lespérance J, et al. Incidence and clinical characteristics of the metabolic syndrome in patients with coronary artery disease. Coron Artery Dis. 2003;14(3):207-12.
Solymoss, B. C., Bourassa, M. G., Lespérance, J., Levesque, S., Marcil, M., Varga, S., & Campeau, L. (2003). Incidence and clinical characteristics of the metabolic syndrome in patients with coronary artery disease. Coronary Artery Disease, 14(3), 207-12.
Solymoss BC, et al. Incidence and Clinical Characteristics of the Metabolic Syndrome in Patients With Coronary Artery Disease. Coron Artery Dis. 2003;14(3):207-12. PubMed PMID: 12702923.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence and clinical characteristics of the metabolic syndrome in patients with coronary artery disease. AU - Solymoss,Bela C, AU - Bourassa,Martial G, AU - Lespérance,Jacques, AU - Levesque,Sylvie, AU - Marcil,Michel, AU - Varga,Susan, AU - Campeau,Lucien, PY - 2003/4/19/pubmed PY - 2003/9/17/medline PY - 2003/4/19/entrez SP - 207 EP - 12 JF - Coronary artery disease JO - Coron Artery Dis VL - 14 IS - 3 N2 - BACKGROUND AND OBJECTIVES: Several studies suggested that the insulin resistance-associated metabolic syndrome (MS) is a major risk factor for coronary artery disease (CAD), but the criteria to identify MS were only recently standardized by the National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III. METHODS: We evaluated the incidence of the newly defined MS in patients with documented CAD and compared the characteristics of patients with and without this syndrome. RESULTS: In a Canadian population with CAD (793 men and 315 women, age 58.1+/-9.8 years) 51% had MS. As compared to patients without the MS syndrome, these patients had significantly higher waist circumference, blood pressure levels and fasting glucose and triglyceride, but lower high-density lipoprotein (HDL)-cholesterol levels. Their homeostatic model assessment (HOMA) insulin resistance index was significantly higher, with indicators of highly atherogenic, small low-density lipoprotein (LDL) and HDL particles. Family history of diabetes and the use of hypoglycemic agents, beta-blockers and thiazides were more frequent, but physical exercise and alcohol consumption were less frequent in MS positive patients. Cumulative coronary stenosis score and the frequency of patients with >50% coronary artery narrowing were higher and there was a strong tendency for higher rates of previous myocardial infarction in MS positive patients. CONCLUSIONS: In a CAD population documented in 1991-1992, 51% of participants had MS and in several respects a more advanced coronary disease than those without the syndrome. These results support the view of NCEP ATP III, that in CAD prevention, beyond lowering LDL-cholesterol levels, interventions concerning the constituents of MS should be important. SN - 0954-6928 UR - https://www.unboundmedicine.com/medline/citation/12702923/Incidence_and_clinical_characteristics_of_the_metabolic_syndrome_in_patients_with_coronary_artery_disease_ L2 - https://doi.org/10.1097/01.mca.0000065744.52558.9f DB - PRIME DP - Unbound Medicine ER -