Tags

Type your tag names separated by a space and hit enter

Effect of obesity on HDL and LDL particle sizes in carriers of the null P207L or defective D9N mutation in the lipoprotein lipase gene: the Québec LipD Study.
Int J Obes Relat Metab Disord. 2003 May; 27(5):631-7.IJ

Abstract

BACKGROUND

We have recently demonstrated that French Canadians bearing a mutation in the lipoprotein lipase (LPL) gene present an impaired lipoprotein-lipid profile characterized by small low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles compared with healthy subjects. It has also been documented that obesity has a significant impact on HDL and LDL particle sizes.

OBJECTIVE

To examine the extent to which obesity modulates HDL and LDL particle sizes among carriers of mutations in the LPL gene.

SUBJECTS

Analyses were carried out in 206 heterozygous carriers of the D9N mutation (N=118) or the P207L mutation (N=88).

MEASUREMENTS

Lipoprotein particle sizes were measured on whole plasma by nondenaturing polyacrylamide gradient gel electrophoresis.

RESULTS

In general, body mass index (BMI) and waist circumference were significant correlates of LDL and HDL particle sizes among heterozygous carriers of the P207L or D9N mutation in the LPL gene, with relatively similar associations among men and women. Multivariate analyses indicated that variations in waist circumference but not BMI were an independent predictor of variations in both HDL particle size (5.2%, P=0.0005) and LDL particle size (5.9%, P=0.01) in the entire group of heterozygotes for LPL mutation in a model that included the nature of the LPL mutation (D9N vs P207L), gender, age, cholesterol and plasma TG levels. Interestingly, there was a significant interaction between plasma TG levels and waist circumference or BMI in modulating HDL particle size. Indeed, an increased waist circumference or BMI was associated with a significant reduction in HDL particle size among subjects with plasma TG levels <or=3.5 mmol/l, but not among those with marked hypertriglyceridemia (TG levels >3.5 mmol/l).

CONCLUSION

These results suggest that abdominal obesity, more so that overall obesity, is an important determinant of variations in LDL and HDL particle size among heterozygous carriers of mutations in the LPL gene, perhaps further contributing to modulate the risk of CHD in these individuals.

Authors+Show Affiliations

Institute on Nutraceuticals and Functional Foods, Laval University, Québec, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12704407

Citation

Ruel, I L., et al. "Effect of Obesity On HDL and LDL Particle Sizes in Carriers of the Null P207L or Defective D9N Mutation in the Lipoprotein Lipase Gene: the Québec LipD Study." International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity, vol. 27, no. 5, 2003, pp. 631-7.
Ruel IL, Gaudet D, Perron P, et al. Effect of obesity on HDL and LDL particle sizes in carriers of the null P207L or defective D9N mutation in the lipoprotein lipase gene: the Québec LipD Study. Int J Obes Relat Metab Disord. 2003;27(5):631-7.
Ruel, I. L., Gaudet, D., Perron, P., Bergeron, J., Julien, P., & Lamarche, B. (2003). Effect of obesity on HDL and LDL particle sizes in carriers of the null P207L or defective D9N mutation in the lipoprotein lipase gene: the Québec LipD Study. International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity, 27(5), 631-7.
Ruel IL, et al. Effect of Obesity On HDL and LDL Particle Sizes in Carriers of the Null P207L or Defective D9N Mutation in the Lipoprotein Lipase Gene: the Québec LipD Study. Int J Obes Relat Metab Disord. 2003;27(5):631-7. PubMed PMID: 12704407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of obesity on HDL and LDL particle sizes in carriers of the null P207L or defective D9N mutation in the lipoprotein lipase gene: the Québec LipD Study. AU - Ruel,I L, AU - Gaudet,D, AU - Perron,P, AU - Bergeron,J, AU - Julien,P, AU - Lamarche,B, AU - ,, PY - 2003/4/22/pubmed PY - 2003/5/20/medline PY - 2003/4/22/entrez SP - 631 EP - 7 JF - International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity JO - Int J Obes Relat Metab Disord VL - 27 IS - 5 N2 - BACKGROUND: We have recently demonstrated that French Canadians bearing a mutation in the lipoprotein lipase (LPL) gene present an impaired lipoprotein-lipid profile characterized by small low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles compared with healthy subjects. It has also been documented that obesity has a significant impact on HDL and LDL particle sizes. OBJECTIVE: To examine the extent to which obesity modulates HDL and LDL particle sizes among carriers of mutations in the LPL gene. SUBJECTS: Analyses were carried out in 206 heterozygous carriers of the D9N mutation (N=118) or the P207L mutation (N=88). MEASUREMENTS: Lipoprotein particle sizes were measured on whole plasma by nondenaturing polyacrylamide gradient gel electrophoresis. RESULTS: In general, body mass index (BMI) and waist circumference were significant correlates of LDL and HDL particle sizes among heterozygous carriers of the P207L or D9N mutation in the LPL gene, with relatively similar associations among men and women. Multivariate analyses indicated that variations in waist circumference but not BMI were an independent predictor of variations in both HDL particle size (5.2%, P=0.0005) and LDL particle size (5.9%, P=0.01) in the entire group of heterozygotes for LPL mutation in a model that included the nature of the LPL mutation (D9N vs P207L), gender, age, cholesterol and plasma TG levels. Interestingly, there was a significant interaction between plasma TG levels and waist circumference or BMI in modulating HDL particle size. Indeed, an increased waist circumference or BMI was associated with a significant reduction in HDL particle size among subjects with plasma TG levels <or=3.5 mmol/l, but not among those with marked hypertriglyceridemia (TG levels >3.5 mmol/l). CONCLUSION: These results suggest that abdominal obesity, more so that overall obesity, is an important determinant of variations in LDL and HDL particle size among heterozygous carriers of mutations in the LPL gene, perhaps further contributing to modulate the risk of CHD in these individuals. UR - https://www.unboundmedicine.com/medline/citation/12704407/Effect_of_obesity_on_HDL_and_LDL_particle_sizes_in_carriers_of_the_null_P207L_or_defective_D9N_mutation_in_the_lipoprotein_lipase_gene:_the_Québec_LipD_Study_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=12704407.ui DB - PRIME DP - Unbound Medicine ER -