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Human dendritic cells activated by TSLP and CD40L induce proallergic cytotoxic T cells.
J Exp Med. 2003 Apr 21; 197(8):1059-63.JE

Abstract

Human thymic stromal lymphopoietin (TSLP) is a novel epithelial cell-derived cytokine, which induces dendritic cell (DC)-mediated CD4+ T cell responses with a proallergic phenotype. Although the participation of CD8+ T cells in allergic inflammation is well documented, their functional properties as well as the pathways leading to their generation remain poorly understood. Here, we show that TSLP-activated CD11c+ DCs potently activate and expand naive CD8+ T cells, and induce their differentiation into interleukin (IL)-5 and IL-13-producing effectors exhibiting poor cytolytic activity. Additional CD40L triggering of TSLP-activated DCs induced CD8+ T cells with potent cytolytic activity, producing large amounts of interferon (IFN)-gamma, while retaining their capacity to produce IL-5 and IL-13. These data further support the role of TSLP as initial trigger of allergic T cell responses and suggest that CD40L-expressing cells may act in combination with TSLP to amplify and sustain pro-allergic responses and cause tissue damage by promoting the generation of IFN-gamma-producing cytotoxic effectors.

Authors+Show Affiliations

DNAX Research Institute, Palo Alto, CA 94304, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

12707303

Citation

Gilliet, Michel, et al. "Human Dendritic Cells Activated By TSLP and CD40L Induce Proallergic Cytotoxic T Cells." The Journal of Experimental Medicine, vol. 197, no. 8, 2003, pp. 1059-63.
Gilliet M, Soumelis V, Watanabe N, et al. Human dendritic cells activated by TSLP and CD40L induce proallergic cytotoxic T cells. J Exp Med. 2003;197(8):1059-63.
Gilliet, M., Soumelis, V., Watanabe, N., Hanabuchi, S., Antonenko, S., de Waal-Malefyt, R., & Liu, Y. J. (2003). Human dendritic cells activated by TSLP and CD40L induce proallergic cytotoxic T cells. The Journal of Experimental Medicine, 197(8), 1059-63.
Gilliet M, et al. Human Dendritic Cells Activated By TSLP and CD40L Induce Proallergic Cytotoxic T Cells. J Exp Med. 2003 Apr 21;197(8):1059-63. PubMed PMID: 12707303.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human dendritic cells activated by TSLP and CD40L induce proallergic cytotoxic T cells. AU - Gilliet,Michel, AU - Soumelis,Vassili, AU - Watanabe,Norihiko, AU - Hanabuchi,Shino, AU - Antonenko,Svetlana, AU - de Waal-Malefyt,Rene, AU - Liu,Yong-Jun, PY - 2003/4/23/pubmed PY - 2003/6/6/medline PY - 2003/4/23/entrez SP - 1059 EP - 63 JF - The Journal of experimental medicine JO - J Exp Med VL - 197 IS - 8 N2 - Human thymic stromal lymphopoietin (TSLP) is a novel epithelial cell-derived cytokine, which induces dendritic cell (DC)-mediated CD4+ T cell responses with a proallergic phenotype. Although the participation of CD8+ T cells in allergic inflammation is well documented, their functional properties as well as the pathways leading to their generation remain poorly understood. Here, we show that TSLP-activated CD11c+ DCs potently activate and expand naive CD8+ T cells, and induce their differentiation into interleukin (IL)-5 and IL-13-producing effectors exhibiting poor cytolytic activity. Additional CD40L triggering of TSLP-activated DCs induced CD8+ T cells with potent cytolytic activity, producing large amounts of interferon (IFN)-gamma, while retaining their capacity to produce IL-5 and IL-13. These data further support the role of TSLP as initial trigger of allergic T cell responses and suggest that CD40L-expressing cells may act in combination with TSLP to amplify and sustain pro-allergic responses and cause tissue damage by promoting the generation of IFN-gamma-producing cytotoxic effectors. SN - 0022-1007 UR - https://www.unboundmedicine.com/medline/citation/12707303/Human_dendritic_cells_activated_by_TSLP_and_CD40L_induce_proallergic_cytotoxic_T_cells_ L2 - https://rupress.org/jem/article-lookup/doi/10.1084/jem.20030240 DB - PRIME DP - Unbound Medicine ER -