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[Epidemiology of left ventricular systolic dysfunction in the general population of Germany: results of an echocardiographic study of a large population-based sample].
Z Kardiol 2003; 92(4):294-302ZK

Abstract

The prevalence of left ventricular systolic dysfunction (LVSD) in the general population is poorly defined. Specifically, the number of asymptomatic individuals with LVSD and, thus, the most appropriate strategy to identify and treat such subjects is still unknown. Therefore, the aim of this study was to document LV dysfunction in a middle-aged (25 to 75 years, mean 51.8+/-13.8) population - based sample in Germany (MONICA Augsburg, n=1678; echocardiography technically adequate n=1418) by M-mode and 2D-echocardiography and to analyze the importance of predisposing contributors. The overall prevalence of an ejection fraction (EF) less than 48% (mean minus 2 SD=LVSD) was 2.3% (n=33), with a slightly higher rate in men than in women (2.8% vs 1.9%, n.s.). LVSD rate increased with age: from 1.5% in individuals younger than 40 years to 4.0% among those older than 60 years of age (p<0.05). Of 33 participants with reduced left ventricular systolic function, 20 presented with at least one cardiovascular disease. The most frequent diagnoses were arterial hypertension, obesity and coronary heart disease. Only 13 subjects (0.9%) of the study population were asymptomatic without a history of cardiovascular disease. Furthermore, only 6 subjects (0.4%, 4 male) in this population presented with a moderate impairment of LV function (EF of 30 to 40%) and only 1 subject (0.07%, male) had severe LVSD (EF less than 30%). Almost all subjects with an EF less than 40% (6 of 7 individuals) had a known history of cardiovascular disease. In conclusion, LVSD is a relatively common finding in the general population. However, severe LVSD is rare in subjects without any concomitant cardiovascular disease. Thus, echocardiographic screening cannot be recommended in the unselected, middle-aged population to identify such patients.

Authors+Show Affiliations

Klinik und Poliklinik für Innere Medizin, Universität Regensburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

ger

PubMed ID

12707788

Citation

Fischer, M, et al. "[Epidemiology of Left Ventricular Systolic Dysfunction in the General Population of Germany: Results of an Echocardiographic Study of a Large Population-based Sample]." Zeitschrift Fur Kardiologie, vol. 92, no. 4, 2003, pp. 294-302.
Fischer M, Baessler A, Holmer SR, et al. [Epidemiology of left ventricular systolic dysfunction in the general population of Germany: results of an echocardiographic study of a large population-based sample]. Z Kardiol. 2003;92(4):294-302.
Fischer, M., Baessler, A., Holmer, S. R., Muscholl, M., Bröckel, U., Luchner, A., ... Schunkert, H. (2003). [Epidemiology of left ventricular systolic dysfunction in the general population of Germany: results of an echocardiographic study of a large population-based sample]. Zeitschrift Fur Kardiologie, 92(4), pp. 294-302.
Fischer M, et al. [Epidemiology of Left Ventricular Systolic Dysfunction in the General Population of Germany: Results of an Echocardiographic Study of a Large Population-based Sample]. Z Kardiol. 2003;92(4):294-302. PubMed PMID: 12707788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Epidemiology of left ventricular systolic dysfunction in the general population of Germany: results of an echocardiographic study of a large population-based sample]. AU - Fischer,M, AU - Baessler,A, AU - Holmer,S R, AU - Muscholl,M, AU - Bröckel,U, AU - Luchner,A, AU - Hense,H-W, AU - Döring,A, AU - Riegger,G, AU - Schunkert,H, PY - 2003/4/23/pubmed PY - 2003/9/30/medline PY - 2003/4/23/entrez SP - 294 EP - 302 JF - Zeitschrift fur Kardiologie JO - Z Kardiol VL - 92 IS - 4 N2 - The prevalence of left ventricular systolic dysfunction (LVSD) in the general population is poorly defined. Specifically, the number of asymptomatic individuals with LVSD and, thus, the most appropriate strategy to identify and treat such subjects is still unknown. Therefore, the aim of this study was to document LV dysfunction in a middle-aged (25 to 75 years, mean 51.8+/-13.8) population - based sample in Germany (MONICA Augsburg, n=1678; echocardiography technically adequate n=1418) by M-mode and 2D-echocardiography and to analyze the importance of predisposing contributors. The overall prevalence of an ejection fraction (EF) less than 48% (mean minus 2 SD=LVSD) was 2.3% (n=33), with a slightly higher rate in men than in women (2.8% vs 1.9%, n.s.). LVSD rate increased with age: from 1.5% in individuals younger than 40 years to 4.0% among those older than 60 years of age (p<0.05). Of 33 participants with reduced left ventricular systolic function, 20 presented with at least one cardiovascular disease. The most frequent diagnoses were arterial hypertension, obesity and coronary heart disease. Only 13 subjects (0.9%) of the study population were asymptomatic without a history of cardiovascular disease. Furthermore, only 6 subjects (0.4%, 4 male) in this population presented with a moderate impairment of LV function (EF of 30 to 40%) and only 1 subject (0.07%, male) had severe LVSD (EF less than 30%). Almost all subjects with an EF less than 40% (6 of 7 individuals) had a known history of cardiovascular disease. In conclusion, LVSD is a relatively common finding in the general population. However, severe LVSD is rare in subjects without any concomitant cardiovascular disease. Thus, echocardiographic screening cannot be recommended in the unselected, middle-aged population to identify such patients. SN - 0300-5860 UR - https://www.unboundmedicine.com/medline/citation/12707788/[Epidemiology_of_left_ventricular_systolic_dysfunction_in_the_general_population_of_Germany:_results_of_an_echocardiographic_study_of_a_large_population_based_sample]_ L2 - https://dx.doi.org/10.1007/s00392-003-0899-2 DB - PRIME DP - Unbound Medicine ER -