Tags

Type your tag names separated by a space and hit enter

Modality-specific changes in P300 parameters in patients with dementia of the Alzheimer type.
Med Sci Monit. 2003 Apr; 9(4):CR130-4.MS

Abstract

BACKGROUND

The relationship between the parameters of the P300 potential and the degree or profile of cognitive decline remains controversial. The aim of our study was to evaluate parameters of auditory and visual P300 in patients with mild and moderate dementia of the Alzheimer type (DAT) and to correlate these with neuropsychological test results.

MATERIAL/METHODS

The study group comprised 13 patients with DAT and 13 healthy, age-matched controls. Auditory and visual event-related potentials were evoked using a basic oddball paradigm. P300 latency and amplitude were compared in patients with DAT and controls and between subgroups of patients with mild and moderate DAT. Correlations between P300 parameters and the results of the Mini-Mental State Examination (MMSE), the Global Deterioration Score (GDS), and the Alzheimer's Disease Assessment Scale (ADAS-cog) were also analyzed.

RESULTS

The mean latency of auditory P300 was significantly prolonged, and the mean amplitude of visual P300 was significantly lower in the DAT patients. 4 patients with DAT (31%) had a prolonged latency of auditory P300. No significant differences in P300 parameters were found between mildly demented and controls or between mildly and moderately demented. A positive correlation was found between MMSE score and auditory P300 latency in Fz and visual P300 amplitude in Cz.

CONCLUSIONS

P300 parameters undergo significant, modality-specific changes in patients with DAT. However, they are not sensitive enough to differentiate early dementia from normal aging.

Authors+Show Affiliations

Department of Neurology, Medical University, Wrocław, Poland. A-Z@pharmanet.com.plNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12709671

Citation

Pokryszko-Dragan, Anna, et al. "Modality-specific Changes in P300 Parameters in Patients With Dementia of the Alzheimer Type." Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, vol. 9, no. 4, 2003, pp. CR130-4.
Pokryszko-Dragan A, Słotwiński K, Podemski R. Modality-specific changes in P300 parameters in patients with dementia of the Alzheimer type. Med Sci Monit. 2003;9(4):CR130-4.
Pokryszko-Dragan, A., Słotwiński, K., & Podemski, R. (2003). Modality-specific changes in P300 parameters in patients with dementia of the Alzheimer type. Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 9(4), CR130-4.
Pokryszko-Dragan A, Słotwiński K, Podemski R. Modality-specific Changes in P300 Parameters in Patients With Dementia of the Alzheimer Type. Med Sci Monit. 2003;9(4):CR130-4. PubMed PMID: 12709671.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modality-specific changes in P300 parameters in patients with dementia of the Alzheimer type. AU - Pokryszko-Dragan,Anna, AU - Słotwiński,Krzysztof, AU - Podemski,Ryszard, PY - 2003/4/24/pubmed PY - 2003/8/2/medline PY - 2003/4/24/entrez SP - CR130 EP - 4 JF - Medical science monitor : international medical journal of experimental and clinical research JO - Med Sci Monit VL - 9 IS - 4 N2 - BACKGROUND: The relationship between the parameters of the P300 potential and the degree or profile of cognitive decline remains controversial. The aim of our study was to evaluate parameters of auditory and visual P300 in patients with mild and moderate dementia of the Alzheimer type (DAT) and to correlate these with neuropsychological test results. MATERIAL/METHODS: The study group comprised 13 patients with DAT and 13 healthy, age-matched controls. Auditory and visual event-related potentials were evoked using a basic oddball paradigm. P300 latency and amplitude were compared in patients with DAT and controls and between subgroups of patients with mild and moderate DAT. Correlations between P300 parameters and the results of the Mini-Mental State Examination (MMSE), the Global Deterioration Score (GDS), and the Alzheimer's Disease Assessment Scale (ADAS-cog) were also analyzed. RESULTS: The mean latency of auditory P300 was significantly prolonged, and the mean amplitude of visual P300 was significantly lower in the DAT patients. 4 patients with DAT (31%) had a prolonged latency of auditory P300. No significant differences in P300 parameters were found between mildly demented and controls or between mildly and moderately demented. A positive correlation was found between MMSE score and auditory P300 latency in Fz and visual P300 amplitude in Cz. CONCLUSIONS: P300 parameters undergo significant, modality-specific changes in patients with DAT. However, they are not sensitive enough to differentiate early dementia from normal aging. SN - 1234-1010 UR - https://www.unboundmedicine.com/medline/citation/12709671/Modality_specific_changes_in_P300_parameters_in_patients_with_dementia_of_the_Alzheimer_type_ L2 - https://www.medscimonit.com/download/index/idArt/4697 DB - PRIME DP - Unbound Medicine ER -