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New antimicrobial alkaloids from the roots of Polyalthia longifolia var. pendula.
Planta Med. 2003 Apr; 69(4):350-5.PM

Abstract

Bioassay-guided isolation studies on the root extract of Polyalthia longifolia var. pendula possessing significant antibacterial activity led to the isolation of three new alkaloids pendulamine A (1), pendulamine B (2) and penduline (3) along with stigmasterol 3-O-beta-D-glucoside, allantoin, the known diterpenoid kolavenic acid, and the azafluorene alkaloid isoursuline. The structures of these compounds have been elucidated with the help of spectroscopic studies including 2D NMR experiments. Compounds 1 and 2, which are the only protoberberine alkaloids having a monosubstituted A ring with a hydroxy group at C-3, were found to be the active antibacterial principles of the roots. Their MIC values ranged between 0.02-20 microg against the tested bacteria.

Authors+Show Affiliations

Faizi S
H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan. shaheen@khi.comsats.net.pk
Khan RA
No affiliation info available
Azher S
No affiliation info available
Khan SA
No affiliation info available
Tauseef S
No affiliation info available
Ahmad A
No affiliation info available

MeSH

AlkaloidsAnti-Bacterial AgentsGram-Negative BacteriaGram-Positive BacteriaHumansMicrobial Sensitivity TestsPhytotherapyPlant ExtractsPlant RootsPolyalthia

Pub Type(s)

Journal Article

Language

eng

PubMed ID

12709903

Citation

Faizi, Shaheen, et al. "New Antimicrobial Alkaloids From the Roots of Polyalthia Longifolia Var. Pendula." Planta Medica, vol. 69, no. 4, 2003, pp. 350-5.
Faizi S, Khan RA, Azher S, et al. New antimicrobial alkaloids from the roots of Polyalthia longifolia var. pendula. Planta Med. 2003;69(4):350-5.
Faizi, S., Khan, R. A., Azher, S., Khan, S. A., Tauseef, S., & Ahmad, A. (2003). New antimicrobial alkaloids from the roots of Polyalthia longifolia var. pendula. Planta Medica, 69(4), 350-5.
Faizi S, et al. New Antimicrobial Alkaloids From the Roots of Polyalthia Longifolia Var. Pendula. Planta Med. 2003;69(4):350-5. PubMed PMID: 12709903.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New antimicrobial alkaloids from the roots of Polyalthia longifolia var. pendula. AU - Faizi,Shaheen, AU - Khan,Rashid Ali, AU - Azher,Soobia, AU - Khan,Shakeel Ahmed, AU - Tauseef,Saima, AU - Ahmad,Aqeel, PY - 2003/4/24/pubmed PY - 2003/7/11/medline PY - 2003/4/24/entrez SP - 350 EP - 5 JF - Planta medica JO - Planta Med VL - 69 IS - 4 N2 - Bioassay-guided isolation studies on the root extract of Polyalthia longifolia var. pendula possessing significant antibacterial activity led to the isolation of three new alkaloids pendulamine A (1), pendulamine B (2) and penduline (3) along with stigmasterol 3-O-beta-D-glucoside, allantoin, the known diterpenoid kolavenic acid, and the azafluorene alkaloid isoursuline. The structures of these compounds have been elucidated with the help of spectroscopic studies including 2D NMR experiments. Compounds 1 and 2, which are the only protoberberine alkaloids having a monosubstituted A ring with a hydroxy group at C-3, were found to be the active antibacterial principles of the roots. Their MIC values ranged between 0.02-20 microg against the tested bacteria. SN - 0032-0943 UR - https://www.unboundmedicine.com/medline/citation/12709903/New_antimicrobial_alkaloids_from_the_roots_of_Polyalthia_longifolia_var__pendula_ DB - PRIME DP - Unbound Medicine ER -