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Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue of the head and neck area: high rate of disease recurrence following local therapy.
Cancer 2003; 97(9):2236-41C

Abstract

BACKGROUND

Mucosa-associated lymphoid tissue (MALT) lymphoma is a distinct entity with specific clinical and pathologic features that may affect diverse organs. MALT-lymphomas remain localized within their original environment for a long period of time. As recent data have demonstrated a relatively high rate of multiorgan involvement at diagnosis, the authors have retrospectively evaluated 36 patients presenting with MALT-lymphoma in the head and neck area. The authors focused on patients' disease localization, initial treatment, clinical course, and follow-up.

METHODS

Thirty-six patients with a histologically verified diagnosis of an extranodal marginal zone B-cell MALT-lymphoma arising in the head and neck area were included in this retrospective analysis.

RESULTS

Treatment consisted of surgical resection as the sole treatment in 4 patients (11%), surgical resection with consecutive radiotherapy in 13 patients (36%), radiotherapy alone in 11 patients (31%), chemotherapy in 2 patients (6%), surgical resection plus radiotherapy and chemotherapy in 4 patients (11%), and combined radiation and chemotherapy in 1 patient (3%). Complete and partial disease remissions after initial treatment were achieved in 22 (61%) and 13 patients (36%), respectively, whereas one patient refused any therapy. Four patients (11%) were lost to follow-up and 15 patients (43%) have had disease recurrence after a median time of 11 months (range, 3-80 months).

CONCLUSIONS

These data suggest that MALT-lymphomas of the head and neck area are preferentially treated using local modalities such as radiation and/or resection. This practice, however, is associated with an unexpectedly high rate of dissemination or disease recurrence. Obtaining an initial complete response is crucial in these patients. According to previous data, the possibility of understaging in such patients cannot be ruled out. Clinical trials with application of systemic treatment are warranted for these patients.

Authors+Show Affiliations

Department of Internal Medicine I/Division of Oncology, University of Vienna, Vienna, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

12712477

Citation

Wenzel, Catharina, et al. "Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue of the Head and Neck Area: High Rate of Disease Recurrence Following Local Therapy." Cancer, vol. 97, no. 9, 2003, pp. 2236-41.
Wenzel C, Fiebiger W, Dieckmann K, et al. Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue of the head and neck area: high rate of disease recurrence following local therapy. Cancer. 2003;97(9):2236-41.
Wenzel, C., Fiebiger, W., Dieckmann, K., Formanek, M., Chott, A., & Raderer, M. (2003). Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue of the head and neck area: high rate of disease recurrence following local therapy. Cancer, 97(9), pp. 2236-41.
Wenzel C, et al. Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue of the Head and Neck Area: High Rate of Disease Recurrence Following Local Therapy. Cancer. 2003 May 1;97(9):2236-41. PubMed PMID: 12712477.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue of the head and neck area: high rate of disease recurrence following local therapy. AU - Wenzel,Catharina, AU - Fiebiger,Wolfgang, AU - Dieckmann,Karin, AU - Formanek,Michael, AU - Chott,Andreas, AU - Raderer,Markus, PY - 2003/4/25/pubmed PY - 2003/5/21/medline PY - 2003/4/25/entrez SP - 2236 EP - 41 JF - Cancer JO - Cancer VL - 97 IS - 9 N2 - BACKGROUND: Mucosa-associated lymphoid tissue (MALT) lymphoma is a distinct entity with specific clinical and pathologic features that may affect diverse organs. MALT-lymphomas remain localized within their original environment for a long period of time. As recent data have demonstrated a relatively high rate of multiorgan involvement at diagnosis, the authors have retrospectively evaluated 36 patients presenting with MALT-lymphoma in the head and neck area. The authors focused on patients' disease localization, initial treatment, clinical course, and follow-up. METHODS: Thirty-six patients with a histologically verified diagnosis of an extranodal marginal zone B-cell MALT-lymphoma arising in the head and neck area were included in this retrospective analysis. RESULTS: Treatment consisted of surgical resection as the sole treatment in 4 patients (11%), surgical resection with consecutive radiotherapy in 13 patients (36%), radiotherapy alone in 11 patients (31%), chemotherapy in 2 patients (6%), surgical resection plus radiotherapy and chemotherapy in 4 patients (11%), and combined radiation and chemotherapy in 1 patient (3%). Complete and partial disease remissions after initial treatment were achieved in 22 (61%) and 13 patients (36%), respectively, whereas one patient refused any therapy. Four patients (11%) were lost to follow-up and 15 patients (43%) have had disease recurrence after a median time of 11 months (range, 3-80 months). CONCLUSIONS: These data suggest that MALT-lymphomas of the head and neck area are preferentially treated using local modalities such as radiation and/or resection. This practice, however, is associated with an unexpectedly high rate of dissemination or disease recurrence. Obtaining an initial complete response is crucial in these patients. According to previous data, the possibility of understaging in such patients cannot be ruled out. Clinical trials with application of systemic treatment are warranted for these patients. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/12712477/Extranodal_marginal_zone_B_cell_lymphoma_of_mucosa_associated_lymphoid_tissue_of_the_head_and_neck_area:_high_rate_of_disease_recurrence_following_local_therapy_ L2 - https://doi.org/10.1002/cncr.11317 DB - PRIME DP - Unbound Medicine ER -